DACC Newsletter Summer 2010 - American Association for Clinical ...
DACC Newsletter Summer 2010 - American Association for Clinical ...
DACC Newsletter Summer 2010 - American Association for Clinical ...
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<strong>DACC</strong> NEWS<br />
Wow how time has flown<br />
by since our Spring Meeting<br />
that was held early in May at<br />
Roche in Nutley New Jersey!<br />
The meeting was very well<br />
attended, and in this economy<br />
that says a lot about the<br />
excellence of the scientific<br />
program. Rosemary Nicklaus<br />
with support from Barbara<br />
Litzenberger did an exceptional<br />
job bringing together complementary<br />
speakers to educate our membership about<br />
emerging research in the pathogenesis, detection<br />
and therapeutic options related to autoimmune<br />
diseases and inflammatory states. The meeting<br />
was launched by Diagen Xu of Roche who provided<br />
an overview the biologic principles underlying<br />
inflammatory dysfunction and described<br />
current and emerging therapeutic approaches,<br />
challenges and opportunities <strong>for</strong><br />
several inflammatory disorders. Provocative<br />
discussions followed, lead by Tom Misko of<br />
Division of Animal <strong>Clinical</strong> Chemistry<br />
Volume 26, Number 2 June <strong>2010</strong><br />
<strong>DACC</strong> Annual Meeting<br />
July 25-29 Anaheim, CA<br />
Message from the Chair<br />
In This Issue:<br />
Pg. 4 <strong>Summer</strong> Meeting Activities<br />
Pg. 5 Annual Symposium Abstract<br />
Pg. 6 Peter Eckersall Recognized <strong>for</strong><br />
Outstanding Contributions to<br />
Animal <strong>Clinical</strong> Chemistry<br />
Pg. 7 <strong>DACC</strong> Relevant Poster Titles<br />
Pg. 9 Photos from the Spring Meeting<br />
Pfizer Global Research & Development, St Louis,<br />
regarding nitrative damage to proteins related to<br />
nitrotyrosine <strong>for</strong>mation and the clinical translatability<br />
of biomarkers in rodent models of rheumatoid<br />
arthritis. Chris Stevenson of Roche also described<br />
relevant animal models <strong>for</strong> asthma and chronic<br />
obstructive pulmonary disease illustrating how in<br />
vivo models continue to be vital <strong>for</strong> furthering the<br />
understanding of disease pathogenesis and <strong>for</strong><br />
developing new therapies. Calvert Louden of<br />
Johnson & Johnson Pharmaceutical Research<br />
and Development propagated the learning<br />
experience with a nice talk broadening our<br />
scope of translatable biomarkers used to assess<br />
systemic inflammatory response syn-
drome. The typical after lunch audience drowsiness,<br />
that befalls some speakers, was not a problem<br />
<strong>for</strong> the entertaining delivery and important in<strong>for</strong>mation<br />
presented by Jon Klover of Covidien<br />
regarding the predictive merits and variable response<br />
of acute phase biomarkers across species<br />
and strains. If the attendees of the Spring Meeting<br />
were not infected with enthusiasm about the science<br />
and value of complement assays by Patsy<br />
Giclas of National Jewish Health, they didn’t have<br />
a pulse. She closed our symposium with pizzazz!<br />
The next opportunity <strong>DACC</strong> members have to get<br />
together is rapidly approaching at the end of July<br />
in Anaheim Cali<strong>for</strong>nia. If you haven’t already done<br />
so, make your travel and registration arrangements<br />
NOW! You don’t want to miss this exciting<br />
week of events in So Cal. On Monday evening<br />
July 26 Siemens Healthcare Diagnostics is continuing<br />
its long running dedication to scientists in<br />
our industry by once again sponsoring the<br />
<strong>DACC</strong>’s Award <strong>for</strong> Outstanding Contributions to<br />
Animal <strong>Clinical</strong> Chemistry, where you and your<br />
partner are invited to the Tortilla Jo’s restaurant at<br />
6:30 pm <strong>for</strong> the <strong>DACC</strong> Mixer and Award Presentation<br />
Reception. On Tuesday morning, July 28, seriously<br />
consider joining us in the <strong>DACC</strong> Executive<br />
Business Meeting at 8:30-10:30am (Hilton Anaheim<br />
Hotel -Capistrano A). Another Tuesday<br />
must-attend-event is our division’s General Business<br />
Meeting and Lunch & Learn session at<br />
12:30-3:30pm (Hilton Anaheim Hotel - Manhattan<br />
Room). After a free lunch we will conduct several<br />
simultaneous in<strong>for</strong>mal round table discussions addressing<br />
our common conundrums, challenges,<br />
approaches, and triumphs. Many relevant and<br />
timely topics will be touched upon and each will be<br />
re-capped <strong>for</strong> the benefit of the greater group.<br />
There will be no charge <strong>for</strong> this novel “LISTSERV<br />
LIVE!” networking event. Whoever said there is no<br />
such thing as a free lunch was wrong, because a<br />
tasty array of delectable victuals will be provided<br />
<strong>for</strong> all who attend the General Business Meeting<br />
and Lunch & Learn session. If you need another<br />
reason to support your request to travel to the Annual<br />
Meeting, this session will provide the type of<br />
in<strong>for</strong>mation that is critical to benchmark and harmonize<br />
operations of preclinical research and<br />
GLP laboratories. On Wednesday July 28, 2:30-<br />
5:30pm, the <strong>DACC</strong> has put together an official<br />
AACC annual meeting symposium in conjunction<br />
with the AACC’s newest <strong>Clinical</strong> Transitional<br />
Science division which specifically caters to interests<br />
in our industry titled “From Bench to Bed-<br />
2<br />
side: <strong>Clinical</strong> Translational Science”. We’d love to<br />
see you in Anaheim!<br />
Recently the <strong>DACC</strong> Secretary, Tracey Boone, resigned<br />
her post to pursue software/middleware<br />
related career opportunities outside the preclinical<br />
industry. We thank her <strong>for</strong> her contribution to the<br />
<strong>DACC</strong> and wish her well. It was heartwarming and<br />
reassuring about the caliber of our membership<br />
that we had several respected scientists, who are<br />
just as busy as the rest of us, step <strong>for</strong>ward to fill<br />
the acute need of our all volunteer division. Compliant<br />
with <strong>DACC</strong> ByLaws, the Executive Committee<br />
appointed a replacement Secretary to serve<br />
out the remainder of the vacated office. The appointment<br />
went to Renée Pearson, MS, DVM, Diplomate,<br />
ACVP (<strong>Clinical</strong> Pathology) of Pearson<br />
Consulting, LLC. The <strong>DACC</strong> is very appreciative<br />
of Renee’s willingness, and those of the other volunteers,<br />
to get involved!<br />
Membership involvement is up this year as evidenced<br />
by the record high attendance at the open<br />
Executive Committee meeting held at the Spring<br />
Meeting. In addition to elected officers and committee<br />
members, several member guests sat in<br />
and contributed to the division’s business and<br />
plans <strong>for</strong> the future. This show of interest and support<br />
was exceptional! Don’t miss the action, the<br />
satisfaction of participation, and the promise of<br />
building strong network bonds. Join us in assuring<br />
the continuing legacy of excellent programs <strong>for</strong><br />
your colleagues and the mission of the <strong>DACC</strong>.<br />
Catch the Multispecies Wave this summer on the<br />
Southern Cali<strong>for</strong>nia coast!<br />
� ~Mike<br />
Division of Animal<br />
<strong>Clinical</strong> Chemistry<br />
And<br />
<strong>Clinical</strong> Transitional Science<br />
Division Symposium<br />
From Bench to Bedside:<br />
<strong>Clinical</strong><br />
Translational Science<br />
Wednesday, July 28, 2:30pm – 5:30pm
A<br />
BIG<br />
<strong>DACC</strong><br />
THANKS!<br />
To:<br />
Roche<br />
For Hosting the <strong>2010</strong> <strong>DACC</strong> Spring<br />
Meeting at Their Facility and <strong>for</strong><br />
Providing Printed Handouts, Breakfast<br />
and Lunch<br />
To:<br />
Siemens Healthcare<br />
Diagnostics<br />
For Organizing and Hosting the<br />
<strong>2010</strong> Spring Multispecies Users<br />
Group Meeting and <strong>for</strong> Providing<br />
Printed Handouts, Breakfast and<br />
Lunch<br />
To:<br />
Sysmex, Ltd.<br />
For Hosting the <strong>DACC</strong> Mixer/Buffet<br />
Dinner and Meet the Speakers<br />
Reception at the <strong>2010</strong> Spring<br />
Meeting<br />
3<br />
<strong>DACC</strong> Supporters<br />
SUSTAINING SPONSORS<br />
Siemens Healthcare Diagnostics<br />
Benefactors<br />
Hoffmann-LaRoche, Inc<br />
Merck & Co., Inc.<br />
Novartis Pharmaceuticals Corporation<br />
Pfizer Global Research and Development<br />
Patrons<br />
Allergan, Inc.<br />
Beckman Coulter<br />
GlaxoSmithKline<br />
Merck Research Laboratories<br />
Sysmex America, Inc.<br />
Contributors<br />
Kay Criswell – Pfizer Global R&D<br />
Friends<br />
John Allinson - ICON Devel Sol’ns<br />
Tracey Boone - Pfizer Global R&D<br />
Bruce D. Car - Bristol-Myers Squibb Co.<br />
Daniela Ennulat - GlaxoSmithKline<br />
Warren Glaab - Merck & Co., Inc.<br />
Elizabeth Hausner, DVM, DABT, DABVT, -<br />
FDA Div Cardiovascular & Renal Drug<br />
Jon Kimball - Potter-Hawkins Group<br />
Jon Klover - Covidien<br />
Calvert Louden, PhD - Johnson &<br />
Johnson Pharm Research & Development<br />
Pankaj Oberoi, PhD - Meso Scale<br />
Discovery<br />
Marielle Odin - Hoffmann-LaRoche<br />
Ralph Parchment, PhD - National Cancer<br />
Institute<br />
Shelli Schomaker - Pfizer Global Research<br />
& Development<br />
Eric Schultz - Lilly Research Laboratories<br />
Frank Sistare, PhD - Merck & Co., Inc<br />
Chris Stevenson, PhD - Hoffmann-LaRoche<br />
Diagen Xu - Hoffmann-LaRoche<br />
David Zelmanovic - LabThroughPut, Inc
�� Division of Animal <strong>Clinical</strong> Chemistry ��<br />
<strong>2010</strong> AACC Annual Meeting Activities<br />
Monday – July 26<br />
<strong>DACC</strong> Reception <strong>for</strong> Outstanding Contributions to Animal <strong>Clinical</strong> Chemistry<br />
Award Presentation and Mixer<br />
Tortilla Jo’s , Downtown Disney - Watch <strong>for</strong> details from the <strong>DACC</strong> Listserver<br />
Hosted again by Siemens Healthcare Diagnostics 6:30pm<br />
Tuesday – July 27<br />
Animal Division Posters Session 01<br />
See Animal Poster Listings (A1 - A19) 10:00am – 12:30pm<br />
<strong>DACC</strong> Executive Committee Meeting<br />
Hilton Anaheim Hotel, Capistrano A Conference Room 8:00am – 10:30am<br />
Open to All Members! Come Join in the Planning of <strong>DACC</strong> Activities!<br />
General Business Meeting and Lunch and Learn<br />
CONUNDRUMS & TRIUMPHS<br />
Hilton Anaheim Hotel, Manhattan Room 12:30pm – 3:30pm<br />
Wednesday – July 28<br />
SYMPOSIA<br />
From Bench to Bedside: <strong>Clinical</strong> Translational Science<br />
2:30pm – 5:30pm<br />
<strong>Clinical</strong> Translational Science Awards(CTSAs), Core Resources in the Age of Translation<br />
Anthony Hayward, MD, PhD, National Center <strong>for</strong> Research Resources, Bethesda, MD<br />
Success Story of <strong>Clinical</strong> Translation from Bench to Bedside: Cystic Fibrosis<br />
Frank Accurso, MD, University of Colorado Denver, Aurora<br />
Translatability of New Biomarkers to <strong>Clinical</strong> Use: Scientific Criteria <strong>for</strong> Success<br />
Lawrence Oliver, PhD, DABCC, NACB, Mayo Clinic, Rochester, MN<br />
Humanized Animal Models: An Emerging Approach <strong>for</strong> Biomarker Development and<br />
Translation<br />
Jirl Aubredecht, PharmD, PhD, Pfizer, Inc., Groton, CT<br />
4
Peter David Eckersall, BSc, MBA, PhD, FRCPath<br />
Named to Receive <strong>2010</strong> <strong>DACC</strong> Award <strong>for</strong><br />
Outstanding Contributions to Animal <strong>Clinical</strong> Chemistry<br />
The <strong>American</strong> <strong>Association</strong> <strong>for</strong> <strong>Clinical</strong> Chemistry<br />
(AACC) Division of Animal <strong>Clinical</strong> Chemistry (<strong>DACC</strong>)<br />
is proud to announce that Peter David Eckersall,<br />
BSc, MBA, PhD, FRCPath has been named the<br />
recipient of the <strong>2010</strong> Award <strong>for</strong> Outstanding Contributions<br />
to Animal <strong>Clinical</strong> Chemistry. This<br />
award, sponsored by Siemens Healthcare Diagnostics,<br />
is awarded to a recipient that has per<strong>for</strong>med<br />
outstanding work in the discipline of animal clinical<br />
laboratory medicine.<br />
Dr. Eckersall has been an innovator in developing<br />
and exploiting a range of clinical biochemistry applications,<br />
particularly acute phase proteins, proteomics<br />
and inflammatory biomarker characterization<br />
of human and animal disease from pathophysiology<br />
to clinical applications. His impact has been<br />
notable in a continuing legacy of education and<br />
teaching in academia, and in numerous workshops<br />
and symposia, in elucidating mechanisms of dis-<br />
5<br />
ease and inflammation in animals/models, as well as<br />
influencing advances in biomarker development;<br />
these contributions include, among many others, Creactive<br />
protein, haptoglobin, serum amyloid A, alkaline<br />
phosphatase isoenzyme methodologies, a1acid<br />
glycoprotein, a2-macroglobulin, tumor necrosis<br />
factor receptor (TNF-R2), and thyroid function and<br />
endocrine assessment in animals.<br />
Dr. Peter David Eckersall is presently Professor of<br />
Veterinary Biochemistry, University of Glasgow Veterinary<br />
School, and Chief Scientific Officer and a Director<br />
of ReactivLab Ltd, a company focused on the<br />
development of acute phase protein tests <strong>for</strong> use in<br />
animal clinical chemistry. In addition, he has initiated<br />
a program to establish a European group <strong>for</strong><br />
the use of proteomics in domestic animal research<br />
and diagnosis, and is also engaged in an international<br />
collaboration setting up a link between Glasgow<br />
Veterinary School and the Veterinary College,<br />
Universiti Putra Malaysia <strong>for</strong> the development<br />
of clinical chemistry and clinical pathology in SE<br />
Asia.<br />
Dr. Eckersall obtained his BS with honors from the<br />
University of Liverpool, an MBA at the University of<br />
Glasgow, and PhD in Biochemistry from the University<br />
of Edinburgh. He became a member of the<br />
Royal College of Pathologists in 1993, and was<br />
elected as a Fellow of the RCPath in 1998. David<br />
Eckersall joined the faculty of the University of Glasgow<br />
Veterinary School in 1980, and has been Professor<br />
of Veterinary Biochemistry since 2002. During<br />
his tenure he has mentored more than eighteen veterinary<br />
postgraduate candidates <strong>for</strong> MVM or PhD<br />
degrees.<br />
Dr. Eckersall has authored or co-authored over 120<br />
peer-reviewed manuscripts, a text book [Animal<br />
<strong>Clinical</strong> Biochemistry, The Future] and 8 book chapters<br />
[most recently in 2008: Eckersall, P.D. (2008)<br />
Proteins, Proteomics and Dysproteinemias, in <strong>Clinical</strong><br />
Biochemistry of Domestic Animals]. He has been a<br />
frequent invited speaker and symposium organizer<br />
<strong>for</strong> over 130 national and international meetings<br />
on topics of proteomics and acute phase protein<br />
biomarkers of inflammation, protein analysis and
Outstanding Contributions to Animal <strong>Clinical</strong> Chemistry, continued...<br />
veterinary diagnosis, and immunogenomics. His research<br />
activities have been highly recognized in the<br />
arenas of proteins, proteomics and dysproteinemias,<br />
cytokines and the acute phase response in posttreatment<br />
reactive encephalopathy following infection,<br />
the use of CRP, haptoglobin, and serum amyloid<br />
A as markers of infection and inflammation, discrimination<br />
between acute and chronic inflammation,<br />
and species differences in the acute phase response<br />
in companion, livestock and laboratory animals.<br />
World-wide interest in the investigation of acute<br />
phase protein in animals has been stimulated by his<br />
research and a University of Glasgow spinout company<br />
ReactivLab Ltd was <strong>for</strong>med (2007) to commercialize<br />
his research.<br />
David Eckersall is also the Leader of a Veterinary<br />
Gene & Protein Group, which is engaged in the application<br />
of molecular genetics and protein analysis<br />
to investigate areas in animal health. The laboratory<br />
has been established as the leading British center<br />
<strong>for</strong> research in animal clinical biochemistry with<br />
funding of £10 million and the group has published<br />
over 300 papers.<br />
Dr. Eckersall has had many honors and distinctions;<br />
he is a Fellow of the Royal College of Pathologists<br />
(FRCPath), serves as an Examiner <strong>for</strong> the MRCPath<br />
in Veterinary <strong>Clinical</strong> Pathology, is a member of the<br />
European Society <strong>for</strong> Veterinary <strong>Clinical</strong> Pathology,<br />
the Animal <strong>Clinical</strong> Chemistry <strong>Association</strong>, the Comparative<br />
<strong>Clinical</strong> Pathology <strong>Association</strong>, and the International<br />
Society <strong>for</strong> Animal <strong>Clinical</strong> Pathology, of<br />
which he was President during1996-1998. He has<br />
cultivated numerous international collaborations with<br />
the Utrecht Veterinary School and seven other laboratories<br />
in an European Union Concerted Action: Ontario<br />
Veterinary College; Atlantic Veterinary College;<br />
School of Veterinary Medicine, Davis Cali<strong>for</strong>nia; International<br />
Laboratory <strong>for</strong> Livestock Research, Nairobi,<br />
Kenya; Institute <strong>for</strong> Animal Health, Compton;<br />
the Moredun Research Institute; and the Faculty of<br />
Veterinary Medicine, University of Perideniya, Sri<br />
Lanka. In 2008, Dr. Eckersall was awarded the distinguished<br />
Heiner Sommer Prize <strong>for</strong> Lifetime Contributions<br />
to Animal <strong>Clinical</strong> Biochemistry by the<br />
International Society <strong>for</strong> Animal <strong>Clinical</strong> Pathology.<br />
6<br />
It is with great pleasure that the Executive and<br />
Awards Committees of the AACC Division of Animal<br />
<strong>Clinical</strong> Chemistry recognize Dr. Peter David Eckersall,<br />
BSc, MBA, PhD, FRCPath as the <strong>2010</strong> recipient<br />
of the <strong>DACC</strong> Award <strong>for</strong> Outstanding Contributions to<br />
Animal <strong>Clinical</strong> Chemistry. The award will be presented<br />
at the <strong>DACC</strong> Reception, sponsored by Siemens<br />
Healthcare Diagnostics, during the <strong>2010</strong> Annual<br />
AACC Meeting in Anaheim, CA.<br />
<strong>DACC</strong> Reception <strong>for</strong> Outstanding<br />
Contributions to Animal <strong>Clinical</strong><br />
Chemistry Award Presentation<br />
The <strong>DACC</strong> Reception and Presentation of our<br />
division’s Award <strong>for</strong> Outstanding Contributions<br />
to Animal <strong>Clinical</strong> Chemistry will be held on<br />
Monday evening July 26 th beginning at 6:30<br />
pm in Downtown Disney at<br />
Tortilla Jo's,<br />
1510 DISNEYLAND DR., ANAHEIM 92802<br />
We gratefully acknowledge that this annual<br />
event is again sponsored by the generous support<br />
of<br />
Siemens Healthcare Diagnostics.
<strong>2010</strong> <strong>DACC</strong>/AACC POSTER SESSION<br />
<strong>2010</strong> <strong>DACC</strong>/AACC POSTER SESSION<br />
Session: 01, Tuesday, July 27, 10:00am – 12:30pm<br />
Please visit the posters at this year's Annual Meeting. The abstracts are the first ones listed in the Annual<br />
Meeting Supplement (A1 – A19), so they are easy to find in the program and will be easy to find on the exhibit<br />
floor. The diversity of these posters will provide valuable in<strong>for</strong>mation on a host of practical issues that<br />
may affect your daily work and provide guidance on potential new directions <strong>for</strong> your laboratory.<br />
<strong>2010</strong> <strong>DACC</strong> Posters<br />
Submitted <strong>for</strong> <strong>DACC</strong> Travel Award Competition<br />
Tuesday, July 27, 10:00 am – 12:30 pm<br />
Session 1 Animal <strong>Clinical</strong> Chemistry<br />
A-01 Toxicity Assessment of the Aqueous Extract of<br />
Calotropis Procera in Rabbits.<br />
J. D. Mbako. University of Yaounde I, Yaounde, Cameroon<br />
A-02 RNase L is involved in hematopoiesis and iron retention.<br />
X. Yi, A. Zhou. Cleveland State University, Cleveland, OH<br />
A-03 The effects of nitric oxide and asymmetric dimethylarginine<br />
in the rat endometriosis model.<br />
T. Cayci, E. O. Akgul, Y. Gulcan Kurt, T. S. Ceyhan, I. Aydin, O.<br />
Onguru, H. Yaman, E. Cakir, C. Bilgi, K. M. Erbil. Gulhane Military<br />
Medical Academy, Ankara, Turkey<br />
A-04 Pentraxin 3 as a Potential Biomarker of Acetaminophen-Induced<br />
Liver Injury.<br />
E. Cakir, E. O. Akgul, I. Aydin, O. Onguru, T. Cayci, Y. Gulcan<br />
Kurt, M. Agilli, F. N. Aydin, M. Gulec, N. Ersoz, T. Turker, H.<br />
Yaman, C. Bilgi, K. M. Erbil. Gulhane Military Medical Academy,<br />
Ankara, Turkey,<br />
A-05 The <strong>Association</strong> between Neopterin and Acetaminophen-Induced<br />
Nephrotoxicity.<br />
E. Cakir, E. O. Akgul, I. Aydin, T. Cayci, Y. Gulcan Kurt, O.<br />
Onguru, F. N. Aydin, M. Agilli, H. Yaman, N. Ersoz, A. Guven, T.<br />
Turker, C. Bilgi, K. M. Erbil. Gulhane Military Medical Academy,<br />
Ankara, Turkey,<br />
A-06 Measurement of TS-131, a New Monopyridinium<br />
Oxime, by High Per<strong>for</strong>mance Liquid Chromatography in Rat<br />
Plasma Samples. Z. I. Kunak 1 , E. O. Akgul 1 , H. Yaren 1 , T. Cayci<br />
1 , Y. Gulcan Kurt 1 , I. Aydin 1 , H. Yaman 1 , L. Kenar 1 , T. Subasi 2 ,<br />
E. Cakir 1 , E. Macit 1 , A. S. Demir 2 , K. M. Erbil 1 , J. Z. Karasova 3 .<br />
1 Gulhane Military Medical Academy, Ankara, Turkey, 2 Middle<br />
East Technical University, Ankara, Turkey, 3 Faculty of Military<br />
Health Sciences, Hradec Kralove, Czech Republic<br />
A-07 Efficacy of Hyperbaric Oxygen Therapy and S-<br />
Methylisothiourea in Experimental Acute Necrotizing Pancreatitis.<br />
O. Altinel, N. Ersoz, B. Uysal, M. Ozturk, T. Cayci, B.<br />
Kurt, I. H. Ozerhan, Y. Gulcan Kurt, H. Yaman, A. Guven, A.<br />
Korkmaz, M. Yasar. Gulhane Military Med Acad, Ankara, Turkey<br />
A-08 Cardioprotective activity of Terminalia arjuna in<br />
Isoproterenol induced Myocardial ischemia in rats. S. K.<br />
Shukla, S. Dwivedi, U. R. Singh, S. B. Sharma. University<br />
college of medical sciences and GTB Hospital, Delhi, India,<br />
7<br />
A-09 Evaluation of Species Specific Calibrations <strong>for</strong><br />
Measuring Albumin in Urine of Dogs and Monkeys using an<br />
Automated Human Immunoturbidometric Assay. D. F. Adams,<br />
K. M. Lynch, T. S. Sellers, D. Ennulat. GlaxoSmithKline,<br />
King of Prussia, PA<br />
A-10 Effect of Vortexing Blood on In Vitro Hemolysis<br />
Assay Results.<br />
D.W. Sprenger, H. L. Jordan. GlaxoSmithKline, Research Triangle<br />
Park, NC<br />
A-11 Effects of phytic acid and exercise on some serum<br />
analytes in rats orally exposed to diets supplemented with<br />
cadmium. T. Daley, S. Omoregie, V. Wright, F. Omoruyi. Northern<br />
Caribbean University, Mandeville, Jamaica<br />
A-12 Effect of sulfite on antioxidant enzymes and lipid<br />
peroxidation in normal and sulfite oxidase-deficient rat<br />
erythrocytes. O. Ozturk 1 , S. Oktar 2 , M. Aydin 3 , V. Kuçukatay 4 ,<br />
N. Yilmaz 1 , Z. Yonden 1 , S. Sogut 1 . 1 Mustafa Kemal University,<br />
Faculty of Medicine, Department of Biochemistry, Hatay, Turkey,<br />
2 Mustafa Kemal University, Faculty of Medicine, Department<br />
of Pharmacology, Hatay, Turkey, 3 Mustafa Kemal University,<br />
Faculty of Medicine, Department of Physiology, Hatay, Turkey,<br />
4 Pamukkale University, Faculty of Medicine, Department of<br />
Physiology, Denizli, Turkey<br />
A-13 Evaluation of an Electrochemiluminescent Immunoassay<br />
<strong>for</strong> Measurement of Insulin in Rat Plasma. R.<br />
McGeary, T. Sellers, D. Ennulat. GlaxoSmithKline, King of Prussia,<br />
PA<br />
A-14 Apoptozis after acute spinal cord injury in rats and<br />
the effect of Erythropoietin(EPO).<br />
Y. E. Doventas 1 , S. Yigit 1 , M. Koldas 1 , B. Ozdemir 2 . 1 Haseki<br />
Edu.and Res.Hospital,<strong>Clinical</strong> Biochemistry, Istanbul, Turkey,<br />
2 Haseki Edu.and Res.Hospital,Neurosurgery, Istanbul, Turkey<br />
A-15 Lateral flow immunochromatographic assay using<br />
europium chelate-loaded silica nanoparticle labels <strong>for</strong><br />
highly sensitive detection of chloramphenicol. W. Yang, X.<br />
Xia, H. Zhang, Y. Xu, Q. LI. XMU, Xiamen, China<br />
A-16 Fructosamine Assay <strong>for</strong> the Veterinary Laboratory.<br />
L. Leon. Catachem Inc., Bridgeport, CT<br />
A-17 The Determination of Enzygnost Thrombin Anti-<br />
Thrombin III Complex in Pig Citrated Plasma to Support<br />
Pre-<strong>Clinical</strong> Toxicology Studies. C. Starks, B. Litzenberger,<br />
M. Genato, J. Dharmadhikari, C. McDonough. Huntingdon Life<br />
Sciences, East Millstone, NJ<br />
A-18 Evaluation of newly developed ELISAs <strong>for</strong> rat,<br />
mouse, dog and pig NGAL.<br />
K. Bangert, J. O. Eriksen, L. O. Uttenthal. BioPorto Diagnostics<br />
A/S, Gentofte, Denmark
A-19 The Effect of Chronic Hypoxia and Carbon Monoxide<br />
on Oxidative Stress in Rat Vascular Tissues. J. Kalra 1 , H.<br />
Neufeld 2 , C. Vandier 3 , R. Wang 4 . 1 Royal University Hospital,<br />
Saskatoon, SK, Canada, 2 University of Saskatchewan, Saskatoon,<br />
SK, Canada, 3 Universite Francois Rabelais de Tours,<br />
Tours, France, 4 Lakehead University, Thunder Bay, ON, Canada<br />
Additional Posters of Interest to <strong>DACC</strong><br />
Submitted <strong>for</strong> <strong>DACC</strong> Travel Award Competition<br />
Tuesday, July 27, 2:00 pm – 4:30 pm<br />
Session 6 Endocrinology/Hormones<br />
B-40 The Measurement of Salivary Testosterone by<br />
Mass Spectrometry and Comparison to Paired Free and<br />
Bio-Available Testosterone Samples. J. Orrock, R. Taylor, S.<br />
Grebe, R. Singh. Mayo Clinic, Rochester, MN<br />
Wednesday, July 28, 10:00 am – 12:30 pm<br />
Session 10 <strong>Clinical</strong> Studies/Outcomes<br />
C-13 Use of clinical biology techniques in clinical practice:<br />
injections of platelet-rich plasma to heal tendon. J.<br />
Kaux1, C. Le Goff2, P. Drion1, F. Pascon1, V. Libertiaux1, A.<br />
Gothot1, S.<br />
Cescotto1, D. Jean-Olivier1, M. Rickert3, J. Crielaard1. 1University<br />
of Liège, Liège, Belgium, 2University Hospital of Liège,<br />
Liège, Belgium, 3University of Heidelberg, Heidelberg, Germany<br />
C-14 New use of VEGF in therapeutics: application in<br />
tendon lesions.<br />
J. Kaux1, L. Caroline2, P. Drion1, V. Libertiaux1, F. Pascon1, A.<br />
Colige1, L. Charles1, B. Nusgens1, S. Cescotto1, J. Defraigne1,<br />
M. Rickert3, J. Crielaard1. University of Liège, Liège, Belgium,<br />
2University Hospital of Liège, Liège, Belgium, 3University of<br />
Heidelberg, Heidelberg, Germany, Chang Gung University,<br />
Taipei, Taiwan<br />
Session 13 Nutrition/Trace Metals/Vitamins<br />
C-130 Nutritional implications and flour functionality of<br />
defatted wheat germ.<br />
M. U. Arshad1, F. M. Anjum2, T. Zahoor3, H. Nawaz2. 1University<br />
of Sargodha, Sargodha, Pakistan, 2University of Agriculture,<br />
Faisalabad, Pakistan, 3Washington State University, Pullman,<br />
WA<br />
C-148 Analysis of serum tryptophan, kynurenine and<br />
kynurenic acid by HPLC.<br />
Y. Z. Xiang, G. A. Tang, P. Y. Ren, X. Q. Zhou, B. X. Luo. Department<br />
of <strong>Clinical</strong> Laboratory, Second Xiangya Hospital,<br />
Central South University, Changsha, P.R., changsha,<br />
China<br />
Thursday, July 29, 9:00 am – 12:00 pm<br />
Session 21 TDM/Toxicology/DAU<br />
E-81 Anti cataract effect of active principle purified<br />
from fruit-pulp of Eugenia jambolana in galactose fed<br />
rats. R. S. Tanwar, S. B. Sharma, V. P. Gupta. University<br />
College of Medical Sciences, University Of Delhi, Delhi,<br />
India<br />
8<br />
A Call To Service<br />
The <strong>DACC</strong> Needs YOU!<br />
Candidates are needed <strong>for</strong>:<br />
� Chair-Elect<br />
� Treasurer<br />
� Nominating Committee<br />
Member<br />
The nominating committee needs to<br />
present candidates, <strong>for</strong> the above roles,<br />
to the Executive Committee at the AACC<br />
Annual Meeting in Anaheim this July.<br />
This is an excellent opportunity <strong>for</strong><br />
members to become more involved in<br />
the division and to <strong>for</strong>m the kind of lasting<br />
professional relationships that are<br />
so valuable <strong>for</strong> professional growth.<br />
If you would like to volunteer <strong>for</strong> one of<br />
these positions, know of someone willing<br />
to serve, or if you’d like additional<br />
in<strong>for</strong>mation about the duties of each position,<br />
please contact Melanie Quinlan or<br />
any member of the Executive Committee.<br />
Don’t pass up this opportunity to<br />
give back to the division and enhance<br />
your career. �<br />
Chair, <strong>DACC</strong> Nominating Committee<br />
Melanie Quinlan
Images from the <strong>2010</strong> <strong>DACC</strong> Spring Meeting: “Autoimmune Diseases and Inflammatory States:<br />
Emerging Research in the Pathogenesis, Detection, and Therapeutic Options ”<br />
Past-Chair Past Chair and Moderator<br />
Rosemary Nicklaus<br />
Rosemary Nicklaus, Thomas Misko, Jon Klover, Calvert Louden, Patricia Giclas,<br />
Barbara Litzenberger, Mike Bieraugel, (not pictured Chris Stevenson, Diagen Xu)<br />
Speaker:<br />
Diagen Xu<br />
9<br />
<strong>DACC</strong> Chair<br />
Mike Bieraugel<br />
Speakers:<br />
Thomas Misko and Jon Klover
A BIG THANKS Goes<br />
Out to Roche <strong>for</strong><br />
Hosting the <strong>DACC</strong><br />
Spring Meeting!!!<br />
<strong>2010</strong> ACVP/ASVCP<br />
CONCURRENT ANNUAL<br />
MEETINGS<br />
October 30– November 3, <strong>2010</strong><br />
Baltimore, MD<br />
http://www.acvp.org/meeting<br />
Awards Presentation<br />
Reception and Mixer<br />
Monday 7/26/<strong>2010</strong><br />
Tortilla Jo’s - Downtown Disney<br />
hosted by<br />
Siemens Healthcare Diagnostics<br />
10<br />
Volunteers are needed <strong>for</strong><br />
<strong>DACC</strong> committees. Join your<br />
colleagues in determining<br />
the future direction of<br />
the division<br />
The <strong>DACC</strong> Election is This Fall !<br />
For Chair-Elect, Treasurer and a Nominating Committee Member<br />
Please Run <strong>for</strong> Office<br />
The Election Process Depends on YOUR Vote !
<strong>DACC</strong> NEWS<br />
Editor Emeritus<br />
Robert E. Emmons<br />
3 Winston Drive<br />
Victor, NY 14564<br />
Phone: 585-924-5019<br />
reemmons@frontiernet.net<br />
Chair-Elect<br />
Barbara Litzenberger<br />
Huntingdon Life Sciences<br />
100 Mettlers Rd.<br />
East Millstone, NJ 08875<br />
Phone: 732-371-0852<br />
LitzenbB@Princeton.Huntingdon.com<br />
Nominating (Year as Chair)<br />
Melanie Quinlan (<strong>2010</strong>)<br />
Roseann Riley (2011)<br />
Karen Lynch (2012)<br />
Kay Criswell (2013)<br />
Mike Bieraugel (Exec Rep)<br />
Awards<br />
Jon Kimball (Chair)<br />
Jiro Kaneko<br />
Bob Emmons<br />
Doug Neptun<br />
<strong>DACC</strong> NEWS<br />
Division of Animal <strong>Clinical</strong> Chemistry<br />
<strong>DACC</strong> NEWS<br />
Editor<br />
Doug Neptun<br />
Antech Diagnostics GLP<br />
507 Airport Blvd, Suite 113<br />
Morrisville, NC 27560<br />
Phone: 919-277-0822<br />
doug.neptun@antechmail.com<br />
<strong>DACC</strong> <strong>2010</strong> Executive Committee<br />
Treasurer<br />
Joseph Sansone<br />
Allergan, Inc.<br />
2525 Dupont Drive, RD2-2C<br />
Irvine, CA 92612<br />
Phone: 714-246-4044<br />
sansone_joseph@allergan.com<br />
Chair<br />
Mike Bieraugel<br />
Allergan, Inc.<br />
2525 Dupont Drive, RD2-2C<br />
Irvine, CA 92612<br />
Phone: 714-246-6051<br />
bieraugel_michael@allergan.com<br />
Membership<br />
Joseph Sansone (Chair)<br />
Rosemary Nicklaus<br />
Ana Maria Roncal-<br />
Lahman<br />
Gail Walter<br />
Spring */<br />
Fall Meeting**<br />
Mike Bieraugel<br />
**Barbara Litzenberger<br />
*Rosemary Nicklaus<br />
Doug Thudium<br />
Kay Criswell<br />
* Principal Organizer<br />
11<br />
<strong>DACC</strong> NEWS<br />
Associate Editor<br />
Mike Bieraugel<br />
Allergan, Inc.<br />
2525 Dupont Drive, RD2-2C<br />
Irvine, CA 92612<br />
Phone: 714-246-6051<br />
bieraugel_michael@allergan.com<br />
Secretary<br />
Renee Pearson<br />
Pearson Consulting, LLC<br />
43332 Sugarbush Court<br />
Leesburg, VA 20176<br />
Phone: 703-663-0768<br />
dr.renee@verizon.com<br />
<strong>DACC</strong> <strong>2010</strong> Committees<br />
Scientific Program &<br />
Long Range Planning<br />
Mike Bieraugel (Chair)<br />
Rosemary Nicklaus<br />
Doug Thudium<br />
Kay Criswell<br />
Annual Meeting<br />
Rosemary Nicklaus (<strong>2010</strong>)<br />
Mike Bieraugel (2011)<br />
Doug Thudium<br />
Kay Criswell<br />
<strong>DACC</strong> NEWS<br />
Associate Editor<br />
Jon P. Kimball<br />
1732 Old Lystra Road<br />
Chapel Hill, NC 27517<br />
Phone: 919-967-4016<br />
jonkimball@msn.com<br />
Past-Chair<br />
Rosemary Nicklaus<br />
Roche<br />
340 Kingsland Street<br />
Nutley, NJ 07110-1150<br />
Phone: 973-235-3654<br />
rosemary.nicklaus@roche.com<br />
Fund Raising<br />
Jon Kimball<br />
Doug Neptun<br />
Chris Perigard<br />
Joe Sansone (Exec Rep)<br />
Regulatory Affairs &<br />
Intersociety Liaison<br />
Jon Kimball:<br />
ISACB<br />
Gail Walter:<br />
ASVCP/SOT/STP