NCN CHEMISTRY NCN NEWS - AlzChem

NCN CHEMISTRY
NCN
NEWS
NCN
www.alzchem.com
LATEST NEWS
Guanidinoacetic acid as active ingredient in CreAMINO®
NUTRITION AND MORE
Premium products made in Germany
SERVICES
GMP at AlzChem Trostberg GmbH
EDITION 1/2010

NCN CHEMISTRY
NCN
NEWS
NCN
BY DR. BARBARA NIESS & DR. HANS-PETER KRIMMER
EDITORIAL
Nutrition and More
Dear reader,
after a three years absence we are
pleased to present to you the ninth
edition of our product newsletter – this
time with a completely new look! The
NCN Chemistry News is the follow-up of
the former Cyanamide Newsletter and
will be published in a similar frequency as
before.
Historically NCN chemistry constitutes our
chemical roots and remains a focus in our
business. Beyond this, AlzChem offers a
variety of products, applications and technology
which is not directly grafted on to
the NCN chemistry chain.
A few of our products, services and innovations
are presented in this edition. Be
curious and learn about our activities in
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EDITION 1-2010
the field of dietary supplements, cosmetics,
pharma and feed.
Our latest success in this area is the approval
in the EU in late 2009 of guanidinoacetic
acid as nutritional feed additive
for chickens. Guanidinoacetic acid is the
active ingredient of a formulated additive
placed on the market under the brand
name CreAMINO®.
In the last year a change of the ownership
of the AlzChem Group from Evonik
Degussa GmbH to the private investor
group bluO took place. The strategy of
AlzChem was not influenced by this
change. We are still deeply committed to
serve our customers and will be a reliable
partner for you also in the future.
LATEST NEWS
Guanidinoacetic acid
- a new product in AlzChem´s portfolio
Guanidinoacetic acid (GAA) is a compound that is closely connected to
creatine; a molecule which is manufactured here in Trostberg for more
than 10 years (see next page). In fact, GAA is the direct biosynthetic
precursor of creatine, lacking just the methyl group. In its pure form it
is a colourless, odourless powder which can be taken-up with the diet.
Vertebrates are able to transform exogenous guanidinoacetic acid into
creatine in the body by use of an enzyme called GAMT. Hence, guanidinoacetic
acid is a source of creatine!
Since October 2009 guanidinoacetic acid has been authorized in the EU
as a nutritional feed additive for chickens (EC 904/2009). It was proven
in numerous scientific feeding trials that GAA leads to a significantly
better feed conversion rate in chickens.
Guanidinoacetic acid is the active ingredient of a formulated additive
now marketed by Evonik Degussa GmbH under the brand name
CreAMINO®.
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NCN CHEMISTRY
NCN
NEWS
NCN
Did you know…?
Creatine is a nitrogenous
organic acid that occurs
naturally in vertebrates and
helps to supply energy to
muscle and other tissue. Creatine
was identified in 1832
when Michel Eugène Chevreul
discovered it as a component
of skeletal muscle. He later
named creatine after the
Greek word for flesh, κρέας
(kreas). Also the name ´sarcosine’
comes from another
Greek word for flesh
(σάρξ, sarx = flesh).
Sarcosine was first isolated by
Justus von Liebig from meat
broth, which led to its name.
Today, AlzChem produces
creatine from sarcosine and
cyanamide, which finally
closes the circle.
By the way, another natural
compound, occurring in the
human body is named after
flesh: L-Carnitine; but here
the Romans and not the
Greek were the patrons.
Carnus: Latin word for flesh.
Creapure®
- premium brand for
creatine monohydrate worldwide
Creatine and its phosphorylated form
phosphocreatine play a crucial role in
energy metabolism. The pair are involved
in making ATP available for all energy
consuming processes in the body.
In numerous studies, supplementation
with creatine monohydrate proved to be
efficient for increasing the Cr/PCr pool
and optimising the energy status.
Creatine is still closely associated with
high intensity exercise but there are many
more interesting applications – the recent
scientific literature being the best proof of
that.
Discover Creapure® for every day life
at www.creapure.com and learn about
creatine benefits for the aging population,
bone health, brain power and much more.
Additionally, creatine monohydrate is
offered in pharmaquality.
4
EDITION 1-2010
You also have the chance to meet us in
2010 at the following trade shows and
symposia:
• Vitafoods: May, 18th to 20th in
Geneva, Switzerland
• Creatine in Health and Sport 2010
(Conference), July, 7th to 10th in
Cambridge, England
• SupplySide West: October,
20th to 22nd in Las Vegas, USA
• Health Ingredients: November,
16th to 18th in Madrid, Spain
Besides pure creatine monohydrate, a couple
of creatine salts and blends are also
offered fulfilling special customer needs.
These are
• Creatine Pyruvate
• Creatine Citrate
• Crea-Trona® (blend of buffered
creatine monohydrate)
Alipure®
- unique supplement for whole body protection
Alpha lipoic acid (ALA) is a naturally
occuring dithiol compound which upon
supplementation has been shown to
comprise beneficial effects on the brain
and on metabolism. Via regeneration of
glutathione (GSH), Vitamin C, Vitamin E
and coenzyme Q10 ALA comes into play
in situations where the balance between
oxidative and antioxidative processes is
disturbed.
AlzChem manufactures racemic alpha
lipoic acid and offers with Alipure® a
special quality for the dietary supplement
application - free of organic solvents. For
pharma applications – like in the field of
diabetic polyneuropathies – a recrystallized
quality is provided in the form of
Alipure® P.
The new alpha lipoic acid powder formulation
Alipure® CD features some
interesting advantages allowing for new
applications:
• Increased stability and shelf life
• Improved organoleptic properties
• For powder blends containing minerals/mineral
salts
• For low moisture functional foods
5
Alipure® CD.
CD stands for cyclodextrin.
Cyclodextrins
are a class of compounds
belonging to the
cyclic oligosaccharides.
They comprise a cavity
where a second molecule,
like alpha lipoic acid
can squeeze in between
forming a complex like
that shown above.
ALIPURE CD
Creatinine The New Alpha-Lipoic Acid Powder Formulation
ALIPURE
The unique supplement for WHOLE BODY PROTECTION
– not just a waste product
Creatinine is closely connected to creatine
by its role as the natural metabolic
degradation product of creatine. Synthetically,
it is likewise derived from creatine
monohydrate being formed under acidic
conditions.
Creatinine has applications e. g. in cosmetics
and diagnostics. Up on request,
creatinine can also be supplied in pharma
quality.
ALIPURE CD
To protect the unique efficacy of ALIPURE in challenging
environments such as oxygen/high temperature/mineral
powder blends
Applications and Advantages
› Increased stability and shelf life
› Improved organoleptic properties
› For powder blends containing minerals/mineral salts
› For low moisture functional foods
› For foods processed at elevated temperature

NCN CHEMISTRY
NCN
NEWS
NCN
The GMP plant at AlzChem´s
site in Trostberg built during
2001/2002.
GMP - For high quality products
The named products explained before are
manufactured in a GMP plant qualified
according to international GMP standards.
GMP stands for Good Manufacturing
Practice and covers clearly defined
and controlled processes during manufacturing,
quality control and warehousing
where specials measures are
applied in critical steps.
Validated processes are applied as necessary
to ensure consistency and compliance
with specifications. For the consumer this
means a plus in terms of safety and consistent
quality of the products.
What can we do for you?
Our GMP plant has the following technical
equipment with a design according to
international GMP standards:
6
EDITION 1-2010
• 5 reactors with a total volume of
45 m³ (hastelloy, enamel, stainless
steel, two with a distillation device,
one with a distillation column)
• 3 solid/liquid separation units:
pressure nutsch (8 m²), centrifuge
(800 mm), Larox-filter (10 m²)
• Cone drier (6 m³, 2 m³)
• Thin film evaporater/short path
distillation combination
(50 ltr/h, vacuum < 0,01mbar)
• Ultrapure water equipment 1,5 m³/h
• Reaction temperature:
-20 °C to 150 °C
• Pressure: vacuum-suitable up to
11,6 psig (8 barg)
• Off gas cleaning: scrubber and
cryo-condensation (down to -70 °C)
Our highly motivated and trained
staff care for your product!
The products at a glance
CreAMINO®
CAS Nr.: 352-97-6
Assay (GAA): min. 96 %
Creapure®
CAS Nr.: 6020-87-7
Assay: min 99.9 %
Creatine Monohydrate,
pharmagrade
pharmagrade
CAS Nr.: 6020-87-7
Assay: 99.0 – 103.0 %
Creatine Anhydrous
CAS Nr.: 57-00-1
Assay: min. 98.0 %
Creatine Pyruvate
CAS Nr.: 208535-04-0
Assay: min. 95 %
Creatine Citrate
CAS Nr.: 331942-94-0
Assay: 97 %
Crea-Trona®
CAS Nr.: Creatine MH 6020-87-7
Na2CO3 7542-12-3
NaHCO3 144-55-8
Assay (creatine MH): min. 94 % %
Alipure® (solvent-free)
CAS Nr: 1077-28-7
Assay: min. 97 % %
Alipure® NS (no silica)
CAS Nr.: 1077-28-7
Assay: min. min. 97 % %
Alipure® P
CAS Nr.: 1077-28-7
Assay: min. 97 %
Alipure® CD
Alipure CD consists of alpha lipoic acid
and alpha alpha cyclodextrin.
CAS Nr.: alpha lipoic lipoic acid 1077-28-7
alpha alpha cyclodextrin 10016-20-3
Assay (alpha lipoic lipoic acid): min. 12 %
Creatinine
CAS Nr.: 60-27-5
Assay: min. min. 98 % %
A Drug Master File (DMF) exists for Creatine Monohydrate,drate,
pharmagrade and for Alipure® P.
7

Contact information
Marketing Nutrition & More
Dr. Peter Hafner
T +49 8621 86-3042
F +49 8621 86-503042
peter.hafner@alzchem.com
Sales Nutrition & More USA/Canada
Susanne Hayes
T +1 770 804 0371
F +1 770 804 0375
susanne.hayes@alzchem.com
General correspondence and R&D Nutrition & More
Dr. Barbara Nieß
T +49 8621 86-2515
F +49 8621 86-502515
barbara.niess@alzchem.com
This newsletter is also available on the
internet at www.alzchem.com
This information is based on our present state of knowledge and is intended to provide general notes on our products and their uses.
Thereforce, we do not guarantee any specific properties of these products or their suitability for a particular application. Existing patent
rights must be observed. This information supersedes all previous information. It is recommended to determine the suitability of our
suggestions and products before using them on a commercial scale.
4
A strong and innovative partner.
Sales Nutrition & More (except USA/Canada)
Verena Löber
T +49 8621 86-2622
F +49 8621 86-502622
verena.loeber@alzchem.com
Contact Guanidinoacetic acid/CreAMINO®
Dr. Ulrike Braun
T +49 8621 86-3197
F +49 8621 86-503197
ulrike.braun@alzchem.com
COMPANY
INFORMATION
Publisher
AlzChem Trostberg GmbH
83308 Trostberg
T +49 8621 86-0
F +49 8621 86-2020
info@alzchem.com