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Patrón - PIEL-L Latinoamericana

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REVISANDO LA HISTORIA<br />

En 1930 Haitinger desarrolló la<br />

técnica de fluorescencia secundaria<br />

empleando un fluorocromo.<br />

En 1950 Coons y Kaplan utilizaron<br />

los anticuerpos marcados con<br />

fluoresceína para localizar<br />

antígenos en los tejidos<br />

(inmunofluorescencia)<br />

Stanley JR. Pemphigus and pemphigoid as paradigms of<br />

organ-specific, autoantibody-mediated diseases. J Clin Invest<br />

1989;83:1443-8.

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