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mecanismos farmacocineticos de las interacciones ... - eVirtual UASLP

mecanismos farmacocineticos de las interacciones ... - eVirtual UASLP

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◦ Prueba <strong>de</strong> significancia: Diferencia entre 2 medias<br />

(“t” Stu<strong>de</strong>nt):<br />

◦S 2 x = ∑(xi-x) 2 / (m-1), S 2 y = ∑(yi-y) 2 / (n-1)<br />

◦gl = m+n-2<br />

◦95% confianza<br />

◦ Determinar t´:<br />

◦t´= x-y/[EEx) 2 + (EEy) 2 ] ½<br />

• Comparar:<br />

T = [tx(EEx) 2 + ty(EEy) 2 ] / [(EEx) 2 + (EEy) 2 ]<br />

◦tx= m-2 gl ty= n-2 gl ( 95% confianza )<br />

◦ Si t´> T la diferencia es significativa<br />

Tallarida RJ. Drug synergism and dose-effect data analysis. Boca Raton, FL: Chapman Hall/CRC Press, 2000

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