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mecanismos farmacocineticos de las interacciones ... - eVirtual UASLP

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Importancia <strong>de</strong> <strong>las</strong> <strong>interacciones</strong><br />

farmacológicas<br />

◦ Mortalidad 13.6% por efectos adversos (31,429).<br />

◦ Clement M. JAMA 2000; 284:93-5<br />

◦ 6,894 muertes (1995)<br />

◦ Chyka PA. Eur J Pharmacol 2000; 109:123-30<br />

◦ 200,000 Interacciones adversas potenciales<br />

(5,358,374 prescripciones) en tres meses.<br />

◦ Guedon Moreau L. Eur J Pharmacol 2003<br />

◦ 5% <strong>de</strong> muertes hospitalarias relacionadas a<br />

fármacos.<br />

◦ Juntti-Patinen L. Eur J Pharmacol 2002;58:479-82

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