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Epigenetica de la obesidad. - Aveso

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FTO


MC4


Nature Genetics Advance Online Publication 14 Dec 2008


Science 318; 1469(2007)


Tejido AdiposoScience 318; 1469(2007)


Science 318; 1469(2007)


PLoS One. 2011; 6(11): e27968.


CADA ALELO:BMI 0,40 a 0,60 kg/m²PESO 1,3 a 2.1 kgRiesgo Obesidad 1,27 a 1,35REPRESENTA EL 20%SUSCEPTIBILIDAD EN LAPOBLACIÓN CAUCASICA.


Obesity Vol 14 Nº4 April 2008


Diabetes 58: 757-764, 2009


J Mol Med. Published online 03 March 2009


TRANSCRIPCIÓNMeti<strong>la</strong>ciónDesmeti<strong>la</strong>ciónREPRESIÓN


BMC Med. 2010; 8: 88.


AJP - Regu PhysiolSeptember 2010 vol. 299no. 3 R711-R722


Am J Clin Nutr April 2011 vol. 93 no. 4 897S-900S


Neuron 69, Feb 24 2011


Arch of Med Res 42(2011)482


885–887(2011)(2011)Nature Chemical Biology 7: 885 2011


1. La influencia <strong>de</strong> FTO en el riesgo <strong>de</strong> obesida<strong>de</strong>s consistente en todos los estudiosrealizados en Caucásicos.22. El riesgo <strong>de</strong> <strong>de</strong>sarrol<strong>la</strong>r Obesidad atribuible aFTO es <strong>de</strong> aproximadamente 20%.3. <strong>Epigenetica</strong> = Meti<strong>la</strong>ción¿FTO = EPIGENETICA?

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