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Principaux antidotes utilisés en toxicologie

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Schémas<br />

• Par voie veineuse (Smilkstein): dose initiale de charge<br />

140 mg/kg, puis 70 mg/kg toutes les 4h, à répéter 12<br />

fois. Dose totale 980 mg/kg; durée totale 48h.<br />

Smilkstein MJ, Bronstein AC, Lind<strong>en</strong> C, Aug<strong>en</strong>stein WL, Kulig KW, Rumack BH:<br />

Acetaminoph<strong>en</strong> overdose a 48‐hour intrav<strong>en</strong>ous N‐acetylcysteine<br />

treatm<strong>en</strong>t protocol. Ann Emerg Med 20: 1058‐63, 1991

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