Marqueurs sérologiques de la maladie coeliaque - Les Jeudis de ...

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Anti-glycan antibodies Anti-laminaribioside carbohydrate AB (ALCA) Anti-chitobioside carbohydrate AB (ACCA) Anti-mannobioside carbohydrate AB (AMCA) Sensibility : 38% (ALCA), 36 % (ACCA), 28% (AMCA) Specificity : 90 %, at least 2 AB : 99 % 44 % of ASCA - CD : anti-glycan + In CD, higher levels of AB (ALCA) associated with small intestine disease. Jeudis de Fleurus 18.12.08 Dotan. Gastroenterology. 2006
ASCA / pANCA Lack of standardization → large interlaboratory variation. Identification of antigens (ANCA) Harmonization of ASCA assays : Cut-offs Ag Jeudis de Fleurus 18.12.08
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Marqueurs sérologiques de la malad
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Anti-réticuline R1 IgA Sensibilit
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Anti-endomysium IFI : cordon ombi
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Anti-transglutaminase (1997 : Diete
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Jeudis de Fleurus 18.12.08
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Anti-transglutaminase TG de GR huma
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Anti-gliadines Sensibilité IgA :
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Page 19 and 20:
Study 137 samples from biopsy-prov
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Specificity 626 patients with colla
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Specificity 400 healthy blood donor
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Sensitivity AGA A AGA G GAF 3X A GA
Page 27 and 28: Comparaison faux positifs Euroimmun
Page 29 and 30: Sévérité de la pathologie D’ap
Page 31 and 32: Déficit en IgA IgA endomysium, tT
Page 33 and 34: Déficit en IgA Sensibilité Spéci
Page 35 and 36: Enfants de moins de 2 ans tTG Sensi
Page 37 and 38: Régime sans gluten Tous les AC di
Page 39 and 40: Régime sans gluten Jeudis de Fleur
Page 41 and 42: Jeudis de Fleurus 18.12.08
Page 43 and 44: Etude avec le kit de Biorad MC,
Page 45 and 46: Jeudis de Fleurus 18.12.08 Plus d
Page 47 and 48: Anti-Actine IgA 4ème colloque du G
Page 51 and 52: Serological Diagnostic Tests Antib
Page 53 and 54: ASCA : Prevalence Crohn’s s disea
Page 55 and 56: ASCA Standard method : Indirect Im
Page 57 and 58: ASCA ELISA : Inova, Euroimmun, Aesk
Page 59 and 60: ASCA : Dots n=24 : 18 CD, 2 UC, 2 I
Page 61 and 62: ASCA Presence of ASCA is stable ov
Page 63 and 64: 59 % of coeliac patients had IgA an
Page 65 and 66: ANCA cANCA pANCA Granular cytoplasm
Page 67 and 68: Target antigen : ? xANCA or NANA (
Page 69 and 70: pANCA + Ulcerative colitis : more
Page 71 and 72: ASCA / ANCA % UC CD Sens Spe Sens S
Page 75 and 76: Anti- exocrine pancreas Prevalence
Page 77: AB against microbial epitopes. Ant
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Marqueurs sérologiques de la maladie coeliaque - Les Jeudis de ...

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