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Médicaments de l'Asthme Aigu Grave Service de ... - SRLF

Médicaments de l'Asthme Aigu Grave Service de ... - SRLF

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Corticostéroroï<strong>de</strong>s et inflammationTrans-activation activation et trans-répressionGCRécepteurscytosoliquesHsp 90DimèreMonomèreCytosolNoyauMembranenucléaireInhibition <strong>de</strong> la transcriptionActivation <strong>de</strong> la transcriptionCytokines (IL-1β, , IL-4, IL-5)Enzymes (PLA 2, COX 2)Facteurs transcription (NFκB B ++)Chémokines(RANTES, IL-8)Lipocortine 1Inhibiteurs protéasesEndopeptidase 24.11I κB B ++EffetsmétaboliquesEffets anti-inflammatoiresinflammatoires

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