Rapport d'activité scientifique 2011 - Faculté de Pharmacie ...

• De Wachter, R.; De Graaf, C.; Keresztes, A.; Vandormael, B.; Ballet, S.; Tóth, G.; Rognan, D.;
Tourwé, D. Synthesis, biological evaluation and automated docking of constrained analogs of the
opioid peptide H-Dmt-D-Ala-Phe-Gly-NH2 using the 4- or 5-methyl substituted 4-amino-1,2,4,5tetrahydro-2-benzazepin-3-one
scaffold. J. Med. Chem. 2011, 54, 653865-47.
• Garcia-Perez, J.; Rueda, P.; Alcami, J.; Rognan, D.; Arenzana-Seisdeos, F.; Lagane, B.; Kellenberger,
E. An allosteric model of maraviroc binding to CCR5. J. Biol. Chem. 2011, 286, 33409-33421.
• Garcia-Perez, J.; Rueda, P.; Staropoli, I.; Kellenberger, E.; Alcami, J.; Arenzana-Seisdedos, F.; Lagane,
B. New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1
infection. J. Biol. Chem. 2011, 286, 4978-4990.
• Guerlet, G.; Spangenberg, T.; Mann, A.; Faure, H.; Ruat, M. Synthesis and biological évaluation of
desmethylveramiline, a micromolar Heggehog inhibitor. Bioorg. Med. Chem. Lett. 2011,
doi:10.1016/j.bmcl.2011.04.103 (2011).
• Haiech, J.; Audran, E.; Fève, M.; Ranjeva, R.; Kilhoffer, MC. Revisiting intracellular calcium
signaling semantics. Biochimie 2011, 93 (12), 2029-2037.
• Halabalaki, M.; Urbain, A.; Paschali, A.; Mitakou, S.; Tillequin, F.; Skaltsounis, AL. Quercetin and
kaempferol 3-O-[α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside]-7-O-α-L-rhamnopyranosides
from Anthyllis hermanniae: Structure determination and conformational studies. J. Nat. Prod. 2011,
74: 1939-1945.
• Heitz, T.; Widemann, E.; Lugan, R.; Miesch, L.; Ullmann, P.; Désaubry, L.; Holder, E.; Grausem, B.;
Kandel, S.; Miesch, M.; Werck-Reichhart, D.; Pinot, F. Cytochromes P450 CYP94C1 and CYP94B3
catalyze two successive oxidation steps of the plant hormone jasmonoyl-isoleucine for catabolic
turnover. J. Biol. Chem. sous presse, doi: 10.1074/jbc.M111.316364.
• Kellenberger, E.; Hofmann, A.; Quinn, RJ. Similar interactions of natural products with
biosynthetic enzymes and therapeutic Targets could explain why nature produces such a large
proportion of existing drugs. Nat. Prod. Rep. 2011, 28, 1483-1492.
• Kellenberger, E.; Kuhn, I.; Schuber, F.; Muller-Steffner, H. Flavonoids as inhibitors of human CD38.
Bioorg. Med. Chem. Lett. 2011, 21, 3939-3942.
• Kessler, R.; Partridge, MR.; Miravitlles, M.; Cazzola, M.; Vogelmeier, C.; Leynaud, D.; Ostinelli, J.
Symptom variability in patients with severe COPD: a pan-European cross-sectional study. Eur. Respir.
J. 2011 Feb;37: 264-72.
• Lamy, V.; Bousserouel, S.; Gossé, F.; Minker, C.; Lobstein, A.; Raul, F. Lupulone triggers p38
MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon
cancer-derived metastatic cells. Oncol. Rep. 2011, 26, 109-114.
• Leuger, J.; Blond, G.; Billard, T.; Haufe, G.; Langlois.; B. 1,4-Additions of electron-rich heterocycles
onto b-perfluoroalkyl enones. J. Fluor. Chem. 2011, doi:10.1016/j.jfluchem.2011.04.004.
• Meslamani, J.; Rognan, D. Enhancing the accuracy of chemogenomic models with a threedimensional
binding site kernel. J. Chem. Inf. Model. 2011, 51, 1593-1603.