Modelli in vitro per la predizione dei rischi da contaminanti ... - Arpa
Modelli in vitro per la predizione dei rischi da contaminanti ... - Arpa
Modelli in vitro per la predizione dei rischi da contaminanti ... - Arpa
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TOXICITY TESTING IN THE 21° CENTURY:<br />
A VISION AND A STRATEGY<br />
US National Academy of Science report, 2007<br />
“… not –so-distant future <strong>in</strong> which virtually all rout<strong>in</strong>e<br />
toxicity test<strong>in</strong>g would be conducted <strong>in</strong> human cells or cell<br />
l<strong>in</strong>es <strong>in</strong> <strong>vitro</strong> by evaluat<strong>in</strong>g cellu<strong>la</strong>r responses <strong>in</strong> a suite of<br />
toxicity pathways assays us<strong>in</strong>g high-throughput tests…”<br />
<strong>da</strong>ll’animale a metodi <strong>in</strong> <strong>vitro</strong> basati su cellule, l<strong>in</strong>ee<br />
cellu<strong>la</strong>ri o componenti cellu<strong>la</strong>ri, preferibilmente di orig<strong>in</strong>e<br />
umana<br />
modelli che mirano al<strong>la</strong> valutazione <strong>dei</strong> processi biologici<br />
di risposta cellu<strong>la</strong>ri <strong>la</strong> cui significativa alterazione può<br />
portare a effetti avversi <strong>per</strong> <strong>la</strong> salute (“toxicity<br />
pathways”)
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