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Figure 1: Antibody titers after <strong>EBV</strong>-infection.<br />
Source: http://www.viomecum.ch/de/konz/Infektiologie/393-394_<strong>EBV</strong>.html<br />
Figure 1 shows the typical immune response in terms of antibody production following<br />
infection with <strong>EBV</strong>. Very early in infection IgM is produced against the early antigen (EA).<br />
Maximum concentrations of antibodies tend to coincide with the onset of symptoms, and<br />
approximately two weeks after initial infection EA IgG, VCA (Virus Capsid Antigen) IgM<br />
and VCA IgG production begins. The highest anti-VCA IgM concentrations are found<br />
around three weeks following the onset of symptoms. EA IgG are often detectable for a<br />
considerable time following infection. Subsequently the concentrations of VCA IgM and<br />
later EA IgG antibodies fall. Anti VCA IgG reaches a peak some six weeks after symptoms<br />
appear and remain at a high level lifelong. Around three weeks after appearance of<br />
symptoms EBNA1 IgG antibodies, which are an indicator of a past infection, begin to be<br />
produced and reach a peak at around seven months and remain at a high level for life<br />
following a normal <strong>EBV</strong> infection. Reactivation of the virus (such as immunosuppression)<br />
usually leads to a significant increase in EA IgG antibodies while VCA IgM titres seldom<br />
increase. Only very occasionally, following immunosuppression, does EBNA1 IgG<br />
disappear so that EA IgG is a good marker for reactivation.<br />
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Symptoms<br />
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VCA-IgM<br />
weeks months years<br />
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