saqarTvelos samedicino Jurnali Medical Journal of Georgia

22ultrastruqturulad mniSvnelovan cvlilebebs.filtvis qsovilSi metabolizmisada ultrastruqturuli organizaciisSecvla ki, mizez-Sedegobrivadiwvevs hipoqsiisa da respiraciuli acidozisCamoyalibebas, izRudeba sisxlidanJangbadis aTviseba, kataboluriproduqtebis utilizacia, icvleba hemohaerovanibarieris struqtura da SesabamisadqveiTdeba misi funqcia.amrigad, tyviis ionebis eqspoziciamcire dozebiTac ki iwvevs eriTrocitebis,gulis kunTisa da filtvebis ultrastruqturuliorganizaciis da lipiduricvlis mniSvnelovan cvlilebebs, romlebickorelaciaSi imyofeba organizmistyviiT datvirTvis intensivobasTan. racmeti raodenobiTaa tyviis ionebi gamoyenebulieqsperimentSi, miT meti siRrmisadestruqciuli cvlilebebi.tyviis eqspoziciis saSiSroeba adamian-Ta janmrTelobisaTvis safuZvlianadaagacnobierebuli msoflio samedicino sazogadoebismier. aRniSnul sakiTxTandakavSirebiT Seqmnilia da xorcieldebamravali programa [CDC’s Lead Poisoning PreventionProgram (National Center for EnvironmentalHealth); Lead Poisoning Prevention Tips: Simple stepsto Protect Your Family From Lead Hazards (Dept. ofHousing and Urban Development, Office of LeadHazard Control): Lead Poisoning Prevention OutreactProgram (Environmental Health Center, environmentalProtection Agency) da sxva], romelic,ZiriTadad, sanitaruli ganaTlebis xasiaTsatarebs da miznad isaxavs garemoSityviis ionebis gabnevis raodenobis Semcirebas.amasTan, naTelia, rom tyviis ionebisgaremoSi gabnevis SeCereba administraciuliwesiT SeuZlebelia. didi materialurixarjebis gaRebis drosac ki Sesa-Zlebelia konkretul regionsa an saxelmwofoSimisi gabnevis mxolod moculobisSemcireba, rac arsebul problemas globaluradver gadawyvets. gamosavali, CveniazriT, tyviis eqspoziciis prevenciisalternatiuli mimarTulebis SemuSaveba-Sia. sadReisod metad aqtualurad migvaCniafarmakopeisaTvis cnobili im bunebrivisamkurnalwamlo saSualebebis gamovlenada SerCeva, romlebic gamodevnisorganizmidan tyviis ionebs da moawesrigebsmaTi eqspoziciiT ganpirobebuldarRvevebs nivTierebaTa cvlis procesebSi.eqsperimentis meore etapze sacdelcxovelebs, ori Tvis ganmavlobaSi, 0,3 da1,9 mg/kg raodenobiT, tyviiT datvirTvisSemdeg, eZleobdaT cal-calke, erTi TvisganmavlobaSi peqtini, askorbinis mJava daglutationi.gamokvleviT dadginda, rom tyviis ionebisorganizmidan gamodevnis mizniT, peqtinisgamoyenebis pirobebSi gamovlenilicvlilebebi sustadaa gamoxatuli da umravlesSemTxvevaSi Seswavlili obieqtebisstruqturuli organizacia umniSvnelodgansxvavdeba normisagan. aRniSnulidakavSirebuli unda iyos peqtinisTvisebasTan, xangrZlivi gamoyenebispirobebSi (erTi Tve), seleqciurad Sebo-Wos tyvia, Seqmnas wyalSi uxsnadi naerTebi(peqtinatebi, peqtatebi) da ukan SewovisgareSe gamodevnos isini kuW-nawlavistraqtis meSveobiT. masTan, SesaZloatyviis organizmidan gamodevnis dadebi-Ti efeqti ufro metad gaZlierdes, TupeqtinTan erTad kompleqsSi gamoyenebuliiqneba iseTi samkurnalwamlo saSualebebi,romlebic moawesrigebs tyviiseqspoziciiT darRveul natif bioqimiurprocesebs (Jangva-aRdgeniTi reaqciebi,SH-jgufebis bloki da a.S.). askorbinismJavasa da glutationis cal-calke gamoyeneba,miuxedavad imisa, rom isini tyviasver gamodevnis organizmidan, dadebiTzegavlenas axdens organizmSi mimdinareprocesebze. askorbinis mJavasa da glutationiskompleqsuri gamoyeneba, savaraudod,ufro metad gaaumjobesebs aRniSnulefeqts, radgan isini urTierTpotenciisgaZlierebiT iwvevs TavianTiTvisebebis intensifikacias.amrigad, rogorc organizmidan tyviisionebis gamodevnis mizniT da misi zemoqmedebiTgamowveuli cvlilebebis gasaneitraleblad,ise tyviis eqspoziciisprevenciul saSualebad SesaZlebeliagamoyenebul iqnes peqtinis, askorbinismJavasa da glutationis kompleqsi.