PELONEWS Spring/Summer 2023

PELONews

PELONews Spring/Summer2023 Overview Organoids & Organ-on-a-chip Organoids, and organ-on-a-chip, have transformed the landscape of biomedical research and clinical applications. Organ-on-a-chip platforms replicate the complex microenvironment of organs, integrating multiple cell types and physiological functions onto a single chip. These systems enable researchers to study organlevel responses, drug interactions, and disease mechanisms with high precision. The combination of organoids and organ-on-achip technology offers a powerful approach to simulate human organ systems and bridge the gap between traditional in vitro models and animal testing. This advancement not only enhances our understanding of human biology and disease but also contributes to the development of safer and more effective treatments, while reducing reliance on animal models. The FDA's recognition of these technologies by no longer requiring animal testing reinforces the importance of embracing human-relevant models and ethical alternatives for advancing healthcare and scientific discoveries. Read our article by scanning/clicking the QR code to find out more. Intestine-on-a-Chip for Personalized Medicine Intestine-on-a-chip models also facilitate the study of gastrointestinal diseases, e.g. inflammatory bowel disease, by mimicking the inflammatory responses and barrier dysfunction observed in these conditions. Organoid products for R&D or GMP • Organoid kits with cytokines, media and cells included for culture of organoids • PhenoDrive • ECM Mixtures • Scilia ExtraGel ECM equivalent to the gold-standard in the industry. • Apricell 3-in-1 plate for high throughput drug testing. • Collagen (I, II, III, IV) • Fibronectin • Laminin • Vitronectin Scan/click the QR code to learn about out ECM for 2D & 3D cell culture. 6 I www.pelobiotech.com

Overview Organoids & Organ-on-a-chip PELONews: Can lab-grown brains become conscious? What is consciousness? Are we nothing more than an intricate neuronal circuit? Scan/Click the QR code to read our article here to find out. Apricell 3-in-1 plate To study co-culture Tumour invasion ECM study Drug screening Scilia ExtraGel ECM Reconstituted matrix hydrogel 3D cell culture Angiogenesis Stem cell maintenance and differentiation In-vivo xenograft generation Organoid kits With cell culture medium and cytokines to create cardiac, biliary, breast, brain, lung, liver, vascular organoids New Products ! 7