การพัฒนาตํารับยาสีฟนสมุนไพร - Faculty of Pharmacy, Mahidol ...

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Abstract
Development of Herbal Toothpaste Formulation
Pattarapunn Unaphak, Sirirat Raddusadee
Project advisor : Weena Jiratchariyakul, Aimon Somanabandhu
Department of Pharmacognocy, Faculty of Pharmacy, Mahidol University
Keyword: Herbal Toothpaste Formulation
This project aimed to develop a quality toothpaste formula containing herbal
extract as the active ingredient. The study begins with the selection of herbs from the
book dealing with Thai herbs in dentistry. Andrographis paniculata, Psidium guajava
and Morinda citrifolia were selected. They were extracted with ethanol. The weight of
herbal powder that produced 1 g of the extract (drug extract ratio) was recorded. Thinlayer
chromatograms of the extracts were performed. Two toothpaste bases i.e. paste
base and gel base, were selected and used for the formulation. Three formulations of
herbal toothpastes were achieved. Formulation 1 was paste and prepared from Guava
leaf (Psidium guajava) extract. Formulation 2 was gel and prepared from Andrographis
paniculata herb extract. Formulation 3 was paste and prepared from noni precipitate
extract. The three toothpastes were tested for the stability by keeping them at room
temperature and at 60 o C for two weeks. The stability of toothpastes were evaluated from
the unchange of the color, pH and viscosity. They were stable. The satisfactory of the
users (40 persons) was evaluated as well. They were satisfied with the foam during
brushing the teeth and the freshness after that.