Vasoplegie tijdens cardiopulmonale bypass - UZ Leuven

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Behandeling: Agent Action/Receptor Site Dosage Side Effects Phenylephrine α1-agonist 40-100 μg bolus 0.5-10 μg/min infusion Norepinephrine α1, α2, and β1-agonist 4-10 μg bolus 10-300 ng/kg/min Peripheral vasoconstriction, no inotropic action Potent vasoconstrictor with potential gut ischemia, increases pulmonary vascular resistancy, arrhythmias Vasopressin V1, independent of adrenergic receptors 1-6 U/h infusion Mesenteric ischemia at doses >6 U/h Methylene blue Inhibition of guanylate cyclase 2 mg/kg bolus 0.5 mg/kg/h for 6 h Hemolytic anemia in patients with G6PD deficiency Tabel 1. Lijst van vaak gebruikte vasopressoren voor de behandeling van vasoplegie Greenish-blue coloration of urine and skin
Behandeling: 1 e keus: Phenylephrine, norepinephrine 2 e keus: Vasopressine, (terlipressine) Verdere opties? Methylene blue Glucocorticoiden?
Page 1 and 2: Koen Bos
Page 3 and 4: Definitie vasoplegie: Kenmerken:
Page 5 and 6: Pathofysiologie: Fig 2. Illustratie
Page 7 and 8: Verschil vasoplegie tijdens en na c
Page 9 and 10: Katp kanalen: Activatie door: ATP
Page 11 and 12: Vasopressine: Stijging intracellul
Page 13: Algoritme:
Page 17 and 18: Behandeling: Methylene blue Treed
Page 19: Conclusie: Katp-kanalen, NO syntha

Vasoplegie tijdens cardiopulmonale bypass - UZ Leuven

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