A atividade antigonadotrófica das progestinas (derivados da ... - Merck

8. Viot G, Thévenot R, Paris J, Milano G, Hopkins R. 1985 Etude de la
pharmacocinétique d´un progestatif à l´aide du produit marqué au 14
C ou par méthode froide. J Pharmacol Clin. 4:127-136.
9. Botella J, Paris J, Duc I, Lalhou B. 1988 Nomegestrol acetate binding
to cytosolic progesterone receptor in human endometrium. Med Sci
Res. 16:299-300.
10. Botella J, Duc I, Delansorne R, Paris J, Lahlou B. 1990 Structure-activity
and structure-affinity relationships of 19-nor-progesterone
derivatives in rat uterus. J Endocrinol Invest. 13:905-910.
11. Ojasoo T, Raynaud JP. 1983 Receptor binding profiles of progestins.
In: Jasonni VM, Nenci I, Flamigni C, eds. Steroids and endometrial
cancer. New York: Raven Press; 11-28.
12. Basdevant A, Pelissier C, Conard J, Degrelle, Guyene TT, Thomas JL.
1991 Effects of nomegestrol acetate (5 mg/day) on hormonal, metabolic
and hemostatic parameters in premenopausal women. Contraception.
44:599-605.
13. Friedewald WT, Levy RI, Fredrickson DS. 1972 Estimation of the
concentration of low-density lipoprotein cholesterol in plasma without
the use of the preparative centrifuge. Clin Chem. 181:499-502.
14. Couzinet B, Young J, Brailly S, Chanson P, Schaison G. 1995. Even after
priming with ovarian steroids of pulsatile gonadotropin-releasing
hormone administration, naltrexone is unable to induce ovulation in
women with functional hypothalamic amenorrhea. J Clin Endocrinol
Metab. 80:2102-2107.
15. Thomas G, Plu G, Thalabard JC. 1992 Identification of pulses in hormone
time series using outlier detection methods. Stat Med.
11:2133-2145.
16. Markiewicz L, Hochberg RB, Gurpide E. 1992 Intrinsic estrogenicity
of some progestagenic drugs. J Steroid Biochem Mol Biol. 41:53-58.
17. Botella J, Duranti E, Viader V, Duc I, Delansorne R, Paris J. 1995
Lack of estrogenic potential of progesterone – or 19-nor-progesterone-derived
progestins as opposed to testosterone – or
19-nor-testosterone derivatives on endometrial Ishikawa cells. J Steroid
Biochem Mol Biol. 55:77-84.
18. Barbieri RL, Petro Z, Canick JA, Ryan KJ. 1983 Aromatization of norethindrone
to ethinyl estradiol by human placental microsomes. J
Clin Endocrinol Metab. 57:299-303.
19. Catherino WH, Jordan VC. 1995 Nomegestrol acetate, a clinically
useful 19-norprogesterone derivative which lacks estrogenic activity.
J Steroid Biochem Mol Biol. 55:239-246.
20. Mac Lusky NJ, McEwen BS. 1980 Progestin receptors in rat brain:
distribution and properties of cytoplasmic progestin binding sites.
Endocrinology. 106:192-202.
21. Knobil E, Hotchkiss J. 1994 The menstrual cycle and its neuroendocrine
control. In: Knobil E, Neill J, eds. The physiology of reproduction.
New York: Raven Press; 711-749.
22. Couzinet B, Le Strat N, Brailly S, Schaison G. 1986 Comparative effects
of cyproterone acetate or a long-acting gonadotropin releasing
hormone agonist in polycystic ovarian disease. J Clin Endocrinol Metab.
63:1031-1035.
23. Couzinet B, Thomas G, Thalabard JC, Brailly S, Schaison G. 1989
Effects of a pure antiandrogen on gonadotropin secretion in normal
women and in polycystic ovarian disease. Fertil Steril. 52:42-50.
24. Couzinet B, Pholsena M, Young J, Schaison G. 1993 The impact of a
pure anti-androgen (flutamide) on LH, FSH, androgens and clinical
status in idiopathic hirsutism. Clin Endocrinol (Oxf). 39:157-162.
25. Gravanis A, Schaison G, George M, et al. 1985 Endometrial and pituitary
responses to the steroidal antiprogestin RU 486 in postmenopausal
women. J Clin Endocrinol Metab. 60:156-163.
26. Tikkanen MJ, Nikkilä EA, Kuusi T, Sipinen S. 1982 High density lipoprotein-2
and hepatic lipase: reciprocal changes produced by estrogen
and norgestrel. J Clin Endocrinol Metab. 54:1113-1117.
27. Dorangeon P, Thomas JL, Gillery P, Lumbroso M, Hazard MC. 1992
Short term effects on lipids and lipoproteins of two progestogens used
in post-menopausal replacement therapy. Eur J Clin Res. 3;187-193.
28. Lobo R. 1991 Clinical review 27: effects of hormonal replacement on
lipids and lipoproteins in postmenopausal women. J Clin Endocrinol
Metab. 73:925-930.
29. Salehian B, Wang C, Alexander G, et al. 1995 Pharmacokinetics, bioefficacy,
and safety of sublingual testosterone cyclodextrin in hypogonadal
men: comparison to testosterone enanthate - a clinical research
center study. J Clin Endocrinol Metab. 80:3567-3575.
30. Dorangeon P, Thomas JL, Choisy H, Lumbroso M, Hazard MC. 1993
Effects of nomegestrol acetate on carbohydrate metabolism. Diabète
Metab. 19:441-445.
31. Conard J, Basdevant A, Thomas JL, et al. 1995 Cardiovascular risk
factors and combined estrogen-progestin replacement therapy: a placebo-controlled
study with nomegestrol acetate and
10 – A atividade antigonadotrófica das progestinas (derivados da 19-nortestosterona e da 19-norprogesterona) não é mediada pelo receptor de androgênio