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Anestesia Geral: Inalatória pura; Venosa total ou ... - EMV-FMB

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Uso Combinado de Anestésicos<br />

Toxicidade – aditiva<br />

sinérgica<br />

?<br />

Cetamina + N 2O → ↑ toxicidade<br />

Jevtovic – Todorovic et al – Br J Pharmacol 2000; 130: 1692-1698<br />

P Midazolam + cetamina → ↑ toxicidade (ratos neonatos)<br />

Y<strong>ou</strong>ng et al – Br J Pharmacol 2005; 146: 189-197<br />

P Midazolam + N 2O + Isoflurano (6 horas) (ratos – 7 d)<br />

Neurodegeneração → persistente déficit aprendizado<br />

Jevtovic – Todorovic et al – J Neurosci 2003; 23: 876-882

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