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tratamento farmacológico do diabetes melitus - Centro de Ciências ...

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METABOLISMO<br />

SULFONILURÉIAS – MECANISMO DE<br />

SECREÇÃO DE INSULLINA<br />

K +<br />

Ca ++<br />

SULFONILURÉIAS <strong>de</strong>spolarização<br />

GLICOSE<br />

K +<br />

fecha<br />

(ATP)<br />

(ADP)<br />

(Ca ++ )<br />

AMINOÁCIDOS<br />

PROINSULINA<br />

Ref. Lebovitz,HE: Oral Antidiabetic Agents. In Joslin’s Diabetes Mellitus.<br />

13th ed. Kahn CR, Weir GC, Eds. Lea & Febiger, 1994, p.508-529,<br />

Feinglos MN, Bethel MA. Med Clin North Am 82:757-90,1998.<br />

INSULINA & PEPTÍDEO C

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