Archive of SID
Archive of SID
Archive of SID
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ﺎـﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ ﻥﺎﻧ ﺎﺑ ﺰﯿﻧ ﯽﻟﻮﮑﻟﻮﻣ و ﻞﻤﻋ ﻢﺴﯿﻧﺎﮑﻣ<br />
ﻪﺑﺎﺸـﻣ<br />
ﺎـﻬﻧﺁ ﮏﯿﺘﯿﻨﯿﮐﻮﮐﺎﻣﺭﺎﻓ ﻝﺎﺤﻨﯾﺍ ﺎﺑ . ﺪﻨﺷﺎﺑﯽﻣ<br />
ﺕوﺎﻔﺘﻣ<br />
ﺎـﻣﺍ ،ﺪـﻧﺭﺍﺩ<br />
ﯽﮐﺪـﻧﺍ یﺍﻩﺩوﺭ<br />
ﺏﺬـﺟ ﻪـﮑﻨﯾﺍ ﺎـﺑ ﻼﺜـﻣ . ﺖﺳﺍ<br />
ﻊـﻤﺠﺗ ﺎـﻫﻥﺍﻮﺨﺘـﺳﺍ<br />
ﺭﺩ و ﺖـﺳﺍ ﻻﺎـﺑ ﺎـﻬﻧﺁ ﯽﺑﺎﺨﺘﻧﺍ ﺕﺭﺪﻗ<br />
ﺭﺩ یﺪـﯾﺭو ﻖـﯾﺭﺰﺗﺯﺍ ﺪـﻌﺑ ﺖﻋﺎـﺳ ﮏـﯾ ﺎﺗ ﺎﺒﯾﺮﻘﺗ و ﺪﻨﺑﺎﯾﯽﻣ<br />
ﺭﺩ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﺕﺍﺮـﺛﺍ ( 9)<br />
ﺪـﻨﻧﺎﻣﯽﻣ<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ ، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
ﯽﻗﺎﺑ ﻥﺍﻮﺨﺘﺳﺍ<br />
. ﺖﺳﺍ ﻩﺪﻣﺁ 1 ﻩﺭﺎﻤﺷ ﻝوﺪﺟﺭﺩ ﻒﻠﺘﺨﻣ ﺕﺎﻌﻟﺎﻄﻣ<br />
O ═<br />
OH<br />
│<br />
P―<br />
│<br />
OH<br />
R1<br />
│<br />
C―<br />
│<br />
R2<br />
OH<br />
│<br />
P―<br />
│<br />
OH<br />
R1 R2<br />
Etidronate OH CH3<br />
Clodronate Cl Cl<br />
Tiludronate H CH2SPhenyl-Cl<br />
Pamidronate OH CH2CH2NH2<br />
Dimethyl pamidronate OH CH2CH2N(CH3)2<br />
Alendronate<br />
OH CH2CH2CH2NH2<br />
Ibandronate OH CH2CH2N(CH3)(Pentyl)<br />
Risedronate OH CH2-3-pyridine<br />
Zolendorate OH CH2(1H-imidazole-1-yl)<br />
(<br />
In Vitro<br />
═<br />
ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﺕﺎﺒﯿﮐﺮﺗ ﯽﯾﺎﯿﻤﯿﺷ ﺭﺎﺘﺧﺎﺳ<br />
O<br />
: 1 ﻩﺭﺎﻤﺷ ﻞﮑﺷ<br />
ﻂﯾﺍﺮﺷ)<br />
ﻩﺎﮕﺸﯾﺎﻣﺯﺁﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﺕﺍﺮﺛﺍ<br />
ﺲﯿـﺑ ﻪـﮐ ﺪـﻫﺩﯽـﻣ<br />
ﻥﺎﺸـﻧ ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ یﺎﻫﯽﺳﺭﺮﺑ<br />
ﺎﺑ)<br />
T یﺎﻫﻝﻮﻠﺳ<br />
ﺮﯿﺜﮑﺗ ﺪﻨﯾﺍﺮﻓ ﺭﺩ ﻝﻼﺘﺧﺍ ﺐﺒﺳ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
و ﺮـﯿﺜﮑﺗ ،(<br />
ﻥژ ﯽـﺘﻧﺁ ﻩﺪـﻨﻨﮐ ﻝﺎـﻌﻓ یﺎـﻫﻝﻮﻠـﺳ<br />
یوﺭ ﺮـﺛﺍ<br />
یﺎـﻫژﺎﻓوﺮﮐﺎﻣ ﺪـﯿﻟﻮﺗ ﺭﺩ ﻝﻼﺘـﺧﺍ و ژﺎـﻓوﺮﮐﺎﻣ ﺕﺮﺟﺎـﻬﻣ<br />
ﺭﺩ . ( 21)<br />
ﺪﻧﻮــﺷﯽــﻣ<br />
ﺯﻮــﺘﭘﻮﭘﺁ ﺪــﻨﯾﺁﺮﻓ و ﮏﯿﺴــﮐﻮﺗﻮﺘﯿﺳ<br />
ﻂﯿــﺤﻣ ﺭﺩ T یﺎــﻫﻝﻮﻠــﺳ<br />
ﻪــﮐ ﯽﻧﺎــﻣﺯ ﺮــﮕﯾﺩ یﺍﻪــﻌﻟﺎﻄﻣ<br />
10 ﻪـﺑ و ﺪﻧﺪـﺷ ﻩﺩﺍﺩ ﺖﺸـﮐ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﺎﺑ ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ<br />
ﺭﺩ یﺪـﯾﺭو ﻞﺧﺍﺩ ﻖﯾﺭﺰﺗ ﺯﺍ ﻪﻠﺻﺎﺣ ﺖﻈﻠﻏ ﺝوﺍ ﻪﻄﻘﻧ ﺮﺑﺍﺮﺑ<br />
T یﺎــﻫﻝﻮﻠــﺳ<br />
ﺦــﺳﺎﭘ ﺶﻫﺎــﮐ ،ﺪﻧﺪﯿــﺳﺭ<br />
ﻩﺪــﻧﺯ ﺩﻮــﺟﻮﻣ<br />
ﻥﺍﺰـﯿﻣ ﻪـﺑ ﺮﯿﺛﺎـﺗ ﻦﯾﺍ . ﺪﺷ ﺺﺨﺸﻣ ﺎﻫﻥژﻮﺘﯿﻣ<br />
ﻪﺑ ﻮﯿﺗﺍﺮﻔﯿﻟوﺮﭘ<br />
ﺎـﺑ ﻞـﯿﻟﺩ ﻦﯿﻤﻫ ﻪﺑ . ﺩﻮﺑ ﺎﻫﺖ<br />
ﯿﺳﻮﻧﻮﻣ<br />
ﻪﺑ ﻪﺘﺴﺑﺍو ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ<br />
ﺦـﺳﺎﭘ ﺖﺸـﮐ ﻢﺘﺴـﯿﺳ ﻪـﺑ ﻩﺯﺎـﺗ یﺎـﻫﺖﯿـﺳﻮﻧﻮﻣ<br />
ﻥﺩوﺰـﻓﺍ<br />
. ( 22)<br />
ﺪﯾﺩﺮﮔ ﺡﻼﺻﺍ T یﺎﻫﻝﻮﻠﺳ<br />
ﻮﯿﺗﺍﺮﻔﯿﻟوﺮﭘ<br />
ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﯽﺑﺎﻬﺘﻟﺍﺪﺿ ﺹﺍﻮﺧ<br />
ﺭﺩ ،ﺪﻨﻨﮐﯽﻣ<br />
ﺩﺎﺠﯾﺍ ﺍﺭ ،ﺩﺭﺍﺩ<br />
ﺩﻮﺟو ﺎﻫﻝﻮﻠﺳ<br />
ﻦﯿﺑ ﺭﺩ ﻪﮐ ﻪﭽﻧﺁ<br />
یﺎﻫﻢﯾﺰﻧﺁ<br />
ﺯﺍ ﯽﺧﺮﺑ ،ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻮﻨﯿﻣﺁ ﻥﺎﻧ<br />
ﺶـﻘﻧ و ﻩﺩﺮـﮐ ﻒﻗﻮﺘﻣ ﺍﺭ ( Mevalonate)<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻪﻠﺠﻣ<br />
ﻪﮐ ﯽﻟﺎﺣ<br />
ﺕﺎﻧﻮﻟﺍﻮﻣﺮﯿﺴﻣ<br />
ﺕﺭﺪـﻗ ﺪـﻨﻧﺎﻣ<br />
،ﻥﻮﮔﺎـﻧﻮﮔ<br />
ﯽﻟﻮﻠـﺳ ﻞـﺣﺍﺮﻣ ﻢﯿـﻈﻨﺗﺭﺩ ﯽﯾﺍﺰﺴﺑ<br />
-ﻥﺎـﻧ<br />
ﻝﺎـﻣوﺯﻮﭙﯿﻟ یﺎـﻫﻡﺮـﻓ<br />
. ﺪـﻧﺭﺍﺩ<br />
ﻝﻮﻠـﺳ ﺮﯿﺜﮑﺗ و<br />
ﺖﺴﯾﺯ<br />
ﮏـﯾﺮﺤﺗ ﺎﺑ ،ﺕﺎﻧوﺭﺩﻮﻠﮐ َﺎﺻﻮﺼﺨﻣ ،ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑﻮﻨﯿﻣﺁ<br />
ﺍﺭ ( ﺖﯾﻮﻨﯿـﺳ)<br />
ﻡﻮﯾﻮﻨﯿـﺳ ﺏﺎـﻬﺘﻟﺍ ،ﯽﺘﯿﺴﮐﻮﺗﻮﺘﯿﺳ ژﺎﻓوﺮﮐﺎﻣ<br />
یوﺭ ﻩﺪـﺷ ﻡﺎـﺠﻧﺍ ﯽـﮑﯿﻨﯿﻠﮐ ﺕﺎـﻌﻟﺎﻄﻣ . ﺪـﯾﺎﻤﻧﯽـﻣ<br />
ﺡﻼﺻﺍ<br />
ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﻪـﮐ ﻞـﺻﺎﻔﻣ ﯽﮑﺸﺧ و ﻡﺭﻮﺗ ﻪﺑ ﻼﺘﺒﻣ ﻥﺍﺭﺎﻤﯿﺑ<br />
ﻪـﺑ ﻪﺘﺴـﺑﺍو ﯽﺑﺎﻬﺘﻟﺍ ﺪﺿ ﺕﺍﺮﺛﺍ<br />
ﺪﯾﻮﻣ ،ﺪﻧﺩﻮﺑ ﻩﺩﻮﻤﻧ ﺖﻓﺎﯾﺭﺩ<br />
ﻦﻣﺰـﻣ ﺖـﯾﺮﺗﺭﺁ ﺎـﺑ ﻥﺍﺭﺎـﻤﯿﺑ ﺭﺩ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﺯوﺩ<br />
. ( 5-7)<br />
ﺖﺳﺍ<br />
: ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﮏﯿﺘﻨﯿﮐﻮﮐﺎﻣﺭﺎﻓ<br />
،ﺪﻨﺷﺎﺑﯽﻣ<br />
ﯽﻟﺁ ﺕﺎﻔﺴﻓوﺮﯿﭘ گﻮﻟﺎﻧﺁ<br />
ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ<br />
. ﺖﺳﺍ ﻩﺪﺷ ﻦﯾﺰﮕﯾﺎﺟ ﻦﺑﺮﮐ ﻢﺗﺍ ﮏﯾ ﺎﺑ ﻥﮋﯿﺴﮐﺍ ﻥﺁ ﺭﺩ ﻪﮐ<br />
ﺖـﯿﺗﺎﭘﺁ ﯽﺴـﮐوﺭﺪﯿﻫ ﺎـﺑ ﺍﺭ ﻪﺘﺴـﺑﺍو ﺹﺍﻮﺧ P-C-P ﻩوﺮﮔ<br />
ﺭﺩ ﻞﯿﺴـﮐوﺭﺪﯿﻫ ﻩوﺮﮔ ﺭﻮﻀﺣ ﻪﻄﺳﺍﻮﺑ ﻪﮐ ﺪﻫﺩﯽﻣ<br />
ﻖﯿﺒﻄﺗ<br />
ﺭﺩ ﻝﺎﺜﻣ ﺭﻮﻃ ﻪﺑ<br />
. ﺪﺑﺎﯾﯽ<br />
ﻣ ﺶﯾﺍﺰﻓﺍ ﺖﯿﺻﺎﺧ ﻦﯾﺍ R1 ﺖﯿﻌﻗﻮﻣ<br />
ﺖـﯿﻌﻗﻮﻣ ﺭﺩ ﻞﯿﺴﮐوﺭﺪﯿﻫ ﻩوﺮﮔ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ و ﺕﺎﻧوﺭﺪﯿﺗﺍ<br />
ﻞﮑـﺷ)<br />
ﺖـﺳﺍ ﻩﺪـﺷ<br />
ﯽـﯾوﺭﺍﺩ ﺕﺭﺪـﻗ ﺶﯾﺍﺰـﻓﺍ ﺐﺒـﺳ<br />
ﺏﺬـﺟﺯﺎﺑ ﻥﺩﺮﮐ ﻒﻗﻮﺘﻣ ﺭﺩ ﻞﻣﺍﻮﻋ ﻦﯾﺍ ﺕﺭﺪﻗ . ( 1<br />
،ﺪـﺷﺎﺑﯽـﻣ<br />
ﻪﺘﺴﺑﺍو<br />
R2<br />
R1<br />
ﻩﺭﺎﻤﺷ<br />
ﻩﺮﯿﺠﻧﺯ ﯽﺒﻧﺎﺟ ﺶﺨﺑ ﻪﺑ ﺰﯿﻧ ﻥﺍﻮﺨﺘﺳﺍ<br />
ﺭﺩ ﻥژوﺮـﺘﯿﻧ ﻢﺗﺍ ﮏﯾ یﺍﺭﺍﺩ ﻪﮐ ﯽﯾﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻩﮋﯾﻮﺑ<br />
ﺹﺎـﺧ ﯽﯾﺎﻀـﻓ ﻞﮑـﺷ ﺎﺑ P-C-P ﻩوﺮﮔ ﺯﺍ ﯽﺳﺎﺴﺣ ﻪﻠﺻﺎﻓ<br />
ﺲﯿــﺑ ﺯﺍ ﺮــﺗیﻮــﻗ<br />
ﯽﻬﺟﻮــﺗ ﻞــﺑﺎﻗ ﻥﺍﺰــﯿﻣ<br />
ﻪــﺑ ،ﺪﻨــﺷﺎﺑﯽــﻣ<br />
ﻝﺎــﺜﻣ یﺍﺮــﺑ . ( 8)<br />
ﺪﻨﺘﺴــﻫ<br />
ﻥژوﺮــﺘﯿﻧ ﺪــﻗﺎﻓ یﺎــﻫﺕﺎﻧﻮﻔﺴــﻓ<br />
ﻥژوﺮـﺘﯿﻧ ﻢـﺗﺍ ﮏـﯾ یﺍﺭﺍﺩ ﻪـﮐ ﺕﺎﻧوﺭﺪﻨﻟ ﺁ و ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
100ﺎـﺗ<br />
10 ،ﺪﻨﺘﺴـﻫ<br />
ﻞـﯿﮑﻟﺍ ﻩﺮـﯿﺠﻧﺯ ﺭﺩ ﻪﻄﺳﺍوﯽﺑ<br />
و یﺍﻪﯾﺎﭘ<br />
،ﺪﻨـﺷﺎﺑﯽـﻣ<br />
ﺕﺎـﻧوﺭﺩﻮﻠﮐ ﺎـﯾ ﺕﺎﻧوﺭﺪـﯿﺗﺍ ﺯﺍ ﺮـﺗیﻮـﻗ<br />
ﺮـﺑﺍﺮﺑ<br />
،ﺕﺎﻧوﺭﺪــﻧﺎﺒﯾﺍ)<br />
ﻪــﻧﺎﮔ ﻪــﺳ ﻥژوﺮــﺘﯿﻧ یﺍﺭﺍﺩ ﻪــﮐ ﯽﻠﻣﺍﻮــﻋ<br />
ﺭﺎــﻬﻣ ﺭﺩ ﯽــﺘﺣ ﺪﻨﺘﺴــﻫ ( ﺕﺎﻧوﺭﺪــﻨﻟوﺯ<br />
و ﺕﺎﻧوﺭﺪﯿــﺳﺍ<br />
ﺲﯿﺑﻮـﻨﯿﻣﺁ . ﺪـﻨﻨﮐﯽـﻣ<br />
ﻞﻤﻋ ﺮﺗیﻮﻗ<br />
ﺰﯿﻧ ﻥﺍﻮﺨﺘﺳﺍ ﺏﺬﺟﺯﺎﺑ<br />
ﺮـﻈﻧ ﺯﺍ ﻪـﮑﻠﺑ ،ﯽﺑﺬـﺟﺯﺎﺑ<br />
ﺕﺭﺪﻗ ﺮﻈﻧ ﺯﺍ ﺎﻬﻨﺗ ﻪﻧ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
www.<strong>SID</strong>.ir<br />
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