Archive of SID
Archive of SID
Archive of SID
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79<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ ، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
یﺭوﺮــﻣ<br />
ﻥﺍﺭﺪــــــﻧﺯﺎــﻣ<br />
ﯽــــــﮑـﺷﺰـﭘ<br />
ﻡﻮـــــــﻠـﻋ<br />
ﻩﺎﮕـــــﺸـﻧﺍﺩ<br />
ﻪــــــﻠـﺠﻣ<br />
( 79-87<br />
) 1388 ﻝﺎﺳ ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ 69 ﻩﺭﺎﻤﺷ ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﯽﺑﺎﻬﺘﻟﺍﺪﺿ ﺹﺍﻮﺧ ﯽﺳﺭﺮﺑ<br />
4<br />
ﻥﺎﯿﻤﺗﺎﺣ ﻥﮋﯿﺑ<br />
3<br />
ﺭﻮﯾﺮﻓ ﻦﯾﺮﯿﺷ<br />
2<br />
ﯽﺤﺻﺎﻧ یﺪﻬﻣ ﺪﻤﺤﻣ<br />
1<br />
یﺭﺎﯿﺷ ﺎﺿﺭ<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻪﻠﺠﻣ<br />
ﻩﺪﯿﮑﭼ<br />
ﺢﯿـﺿﻮﺗ و یﺪـﺟ یﺎﻫﯽﺳﺭﺮﺑ<br />
ﺎﻣﺍ ،ﺪﻧﺍﻩﺩﺮﮐ<br />
ﺍﺪﯿﭘ یﺍﻩﺩﺮﺘﺴﮔ<br />
ﻩﺩﺎﻔﺘﺳﺍ ،ﻥﺍﻮﺨﺘﺳﺍ<br />
ﻢﺴﯿﻟﻮﺑﺎﺘﻣ ﺕﻻﻼﺘﺧﺍ ﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻪﭼﺮﮔﺍ<br />
ﺲﯿـﺑ ،ﯽﻤﺴـﯿﻧﺎﮑﻣ و یﺭﺎﺘﺧﺎـﺳ ﺮﻈﻧ ﺯﺍ . ﺖﺳﺍ ﺩوﺪﺤﻣ ﺭﺎﯿﺴﺑ ،ﻥﺪﺑ<br />
ﺭﺩ ﺎﻬﻧﺁ ﯽﻨﻤﯾﺍ ﺡﻼﺻﺍ ﺹﺍﻮﺧ و ﯽﺑﺎﻬﺘﻟﺍ<br />
ﺪﺿ ﻞﺣﺍﺮﻣ و ﺶﻘﻧ ۀﺪﻨﻫﺩ<br />
ﻉﻮـﻨﺗ ﺮـﺑ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﺕﺍﺮﺛﺍ . ﺪﻧﻮﺷﯽﻣ<br />
ﻢﯿﺴﻘﺗ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ ﻥﺎﻧ و ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑﻮﻨﯿﻣﺁ ﻪﺘﺳﺩ وﺩ ﻪﺑ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﻪـﺘﻓﺮﮔﺭﺎﮑﺑ ﺖـﻈﻠﻏ ،ﻩﺪـﺷ ﺶﯾﺎـﻣﺯﺁ ﺕﺎﻧﻮﻔﺴـﻓ ﺲﯿﺑ ﯽﻟﻮﮑﻟﻮﻣ ﻉﻮﻧ ﻪﺑ ﻪﺘﺴﺑ و ﺖﺳﺍ ﻩﺪﯿﭽﯿﭘ ،ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ<br />
ﻂﯾﺍﺮﺷ ﺭﺩ ﻦﯿﮐﻮﺘﯿﺳ<br />
ﺲﯿﺑﻮـﻨﯿﻣﺁ ﻪـﮐ ﺖﺴـﯿﻟﺎﺣ ﺭﺩ ﻦـﯾﺍ . ﺖـﺳﺍ ﺕوﺎـﻔﺘﻣ ﻩﺪـﺷ ﻩﺩﺍﺩ ﺖﺸﮐ یﺎﻫﻝﻮﻠﺳ<br />
ﯽﺑﺎﯾﺯﺭﺍ ﻩﻮﺤﻧ و ﻩﺪﺷ ﺶﯾﺎﻣﺯﺁ ﻝﻮﻠﺳ ﻉﻮﻧ ،ﻩﺪﺷ<br />
ﺪﯿﻟﻮﺗ ﺖﺳﺍ ﻦﮑﻤﻣ ﺎﻫﻥﺁ<br />
ﻦﻣﺰﻣ ﻑﺮﺼﻣ و ﺪﻨﻨﮐﯽﻣ<br />
ﮏﯾﺮﺤﺗ ﻩﺎﺗﻮﮐ ﺕﺪﻣ ﺭﺩ ﺍﺭ ﯽﺑﺎﻬﺘﻟﺍ ﺶﯿﭘ یﺎﻫﻦﯿﮐﻮﺘﯿﺳ<br />
،ﻥﺪﺑ ﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﻂـﺳﻮﺗ ﻪﮐ ﺍﺭ ﯽﻨﻤﯾﺍ ﻢﺘﺴﯿﺳ ﻩﺪﻨﻨﮐ ﻢﯿﻈﻨﺗ و ﯽﺑﺎﻬﺘﻟﺍ ﺪﺿ ﺕﺍﺮﯿﺛﺄﺗ ﻪﻟﺎﻘﻣ ﻦﯾﺍ . ﺪﯾﺎﻤﻧ ﻒﻗﻮﺘﻣ ﺍﺭ ﺎﻫﻦﯿﮐﻮﺘﯿﺳ<br />
ﻦﯾﺍ<br />
. ﺩﺍﺩ ﺪﻫﺍﻮﺧ ﺭﺍﺮﻗ ﯽﺳﺭﺮﺑ ﺩﺭﻮﻣ ﺕﺎﺒﯿﮐﺮﺗ ﻦﯾﺍ ﻩﻮﻘﻟﺎﺑ ﻢﺴﯿﻧﺎﮑﻣ ﻪﺑ ﻊﺟﺍﺭ ﺍﺭ ﺮﯿﺧﺍ ﺶﻧﺍﺩ و ﯽﻧﺎﺴﻧﺍ ﺕﺎﻌﻟﺎﻄﻣو ﺩﻮﺷﯽﻣ<br />
ﺩﺎﺠﯾﺍ<br />
ﺏﺎﻬﺘﻟﺍ<br />
ﺪﺿ ﻞﻣﺎﻋ ﻥﺍﻮﻨﻋ<br />
ﻪﺑ<br />
ﺎﻫوﺭﺍﺩ<br />
ﻦﯾﺍ ﺮﺘﺸﯿﺑ ﻩﺩﺎﻔﺘﺳﺍ ﻊﻧﺎﻣ<br />
یژﻮﻟﻮﮐﺎﻣﺭﺎﻓ ﻥﺪﺷ ﻦﺷوﺭ ﺎﺑ ﺮﯿﺧﺍ یﺎﻫﻝﺎﺳ<br />
ﺭﺩ . ﺖﺳﺍ ﻩﺪﺷ<br />
ﻥﺍﻮﻨﻋ ﻪﺑ<br />
ﺎﻬﻧﺁ ﺩﺮﺑﺭﺎﮐ ﻪﺑ ﻪﺟﻮﺗ ،ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﯽﻟﻮﮑﻟﻮﻣ<br />
ﻩﺪﯾﺩﺮﮔ<br />
ﺡﺮﻄﻣ ﺮﺘﺸﯿﺑ ﻢﺳﻼﭘﻮﺌﻧ ﺪﺿ و ﺏﺎﻬﺘﻟﺍ ﺪﺿ ﻞﻣﺍﻮﻋ<br />
،ﯽﺑﺎﻬﺘﻟﺍ ﺪﺿ ﺹﺍﻮﺧ ﺎﺑ ﺍﺭ ﻞﻣﺍﻮﻋ ﻦﯾﺍ ﺶﻘﻧ ﻩﺪﻨﺴﯾﻮﻧ . ﺖﺳﺍ<br />
ﻩﺩﻮﻤﻧ ﺵﺭﺍﺰﮔ(<br />
ﺖﯾﺮﺗﺭﺁ)<br />
ﻞﺻﺎﻔﻣ ﻡﺭﻮﺗ ﻪﻨﯿﻣﺯ ﺭﺩ َﺎﺻﺎﺼﺘﺧﺍ<br />
ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ،ﯽﻤﺴﯿﻧﺎﮑﻣ و یﺭﺎﺘﺧﺎﺳ ﺮﻈﻧ ﺯﺍ . ( 5)<br />
ﺖﺳﺍ<br />
ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ ﻥﺎﻧ و ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑﻮﻨﯿﻣﺁ ﻪﺘﺳﺩ وﺩ ﻪﺑ<br />
ﺪـﻨﻧﺎﻣ<br />
و ﻩﺩﻮﺑ ATP ﯽﻤﺳ ﻡﺮﻓ ،ﻝوﺍ<br />
ﻪﺘﺳﺩ . ﺪﻧﻮﺷﯽﻣ<br />
ﻢﯿﺴﻘﺗ<br />
E-mail:shiareza@yahoo.com<br />
ﯽﻨﻤﯾﺍ ﻩﺪﻨﻨﮐ<br />
ﻞﯾﺪﻌﺗ ،ﺏﺎﻬﺘﻟﺍ<br />
ﺪﺿ ،ﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ : یﺪﯿﻠﮐ یﺎﻫﻩ<br />
ژﺍو<br />
ﻪﻣﺪﻘﻣ<br />
ﯽﻧﻼﻀﻋ -ﯽﺘﻠﮑﺳﺍ<br />
ﺕﻻﻼﺘﺧﺍ ﻥﺎﻣﺭﺩ ﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ<br />
ﻥﻮﻨﮐﺍ ﻢﻫ ﻪﮐیﺭﻮﻃﻪ<br />
ﺑ ،ﺖﺳﺍ<br />
ﻩﺩﺮﮐ ﺩﺎﺠﯾﺍ یﺍﻩﺪﻤﻋ<br />
ﺖﻓﺮﺸﯿﭘ<br />
ﻥﺎﻣﺭﺩ ﺭﺩ ﻩﺪﺷ ﻪﺘﻓﺮﮔ ﺭﺎﮑﺑ یﺎﻫوﺭﺍﺩ ﻦﯾﺮﺘﻌﯾﺎﺷ ﺯﺍ ﯽﮑﯾ<br />
ﺎﻬﻧﺁ ﺶﻘﻧ ﺩﺭﻮﻣ ﺭﺩ . ﺪﻧوﺭﯽﻣ<br />
ﺭﺎﻤﺸﺑ ﺲﯾﺯﺭﻮﭘﻮﺌﺘﺳﺍ<br />
ﯽﮑﯿﻨﯿﻠﮐ<br />
یﺭﺎﻤﯿﺑ ﺪﻨﻧﺎﻣ<br />
ﯽﻠﺼﻔﻣ و ﯽﻧﺍﻮﺨﺘﺳﺍ ﺕﻻﻼﺘﺧﺍ ﺮﮕﯾﺩ<br />
ﻝﺮﺘﻨﮐﺭﺩ<br />
ﺯوﺮﺒﯿﻓ ،ﯽﻠﻣﺎﮑﺗ ﺕﻻﻼﺘﺧﺍ ،ﯽﻧﺍﻮﺨﺘﺳﺍ<br />
یﺎﻫﺯﺎﺘﺳﺎﺘﻣ ،ﻩژﺎﭘ<br />
ﮏﯿﺘﺗﺎﭙﻤﯿﺳ<br />
ﯽﻓوﺮﺘﺴﯾﺩ ،ﺕﻮﮐﺭﺎﺷ ﯽﺗﺎﭘوﺮﺗﺭﺁ ،ﮏﯿﺘﺳﻼﭙﺴﯾﺩ<br />
. ( 1-4)<br />
ﺩﺭﺍﺩ ﺩﻮﺟو ﯽﺗﺎﺷﺭﺍﺰﮔ ﺰﯿﻧ ﮏﯿﺘﭙﺳﺁ ﺖﯿﻠﯿﻣﻮﺌﺘﺳﺍ و<br />
،ﺲﯾﺯﺭﻮﭘﻮﺌﺘﺳﺍ<br />
ﻥﺎﻣﺭﺩ ﺭﺩ ﻞﻣﺍﻮﻋ ﻦﯾﺍ ﺮﯿﮕﻤﺸﭼ ﺖﯿﻘﻓﻮﻣ<br />
ﺪﯿﻔﻣ ﻥﺎﮐﺩﻮﮐ ﯽﻧﺎﻣﺭﺩ ﯽﺷﺯﻮﻣﺁ ﺰﮐﺮﻣ ﺩﺎﺷﺭﺍ ﻪﯿﻨﯿﺴﺣ ﺯﺍ ﺮﺗﻻﺎﺑ ﯽﺘﻌﯾﺮﺷ . ﺥ ،ﻥﺍﺮﻬﺗ -یﺭﺎﯿﺷ<br />
ﺎﺿﺭ ﺮﺘﮐﺩ : ﻝﻮﺌﺴﻣ ﻒﻟﻮﻣ<br />
ﯽﺘﺸﻬﺑ ﺪﯿﻬﺷ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﯽﮑﺷﺰﭘ ﻩﺪﮑﺸﻧﺍﺩ ﺭﺎﯾﺩﺎﺘﺳﺍ ،ﻥﺎﮐﺩﻮﮐ<br />
ﯽﻤﺴﯿﺗﺎﻣوﺭ<br />
یﺎﻫ یﺭﺎﻤﯿﺑ ﺺﺼﺨﺗ ﻕﻮﻓ . 1<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﺱﺎﻨﺷﺭﺎﮐ ،ﯽﺘﺸﻬﺑ<br />
ﺪﯿﻬﺷ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻝﺎﻔﻃﺍ ﺭﺎﯿﺘﺳﺩ . 2<br />
ﯽﺘﺸﻬﺑ ﺪﯿﻬﺷ ﻩﺎﮕﺸﻧﺍﺩ<br />
ﯽﺘﺴﯾﺯ ﻡﻮﻠﻋ ﻩﺪﮑﺸﻧﺍﺩ ﺭﺎﯾﺩﺎﺘﺳﺍ ،ﮏﯿﺘﻧژ<br />
یﺮﺘﮐﺩ . 3<br />
ﯽﺘﺸﻬﺑ ﺪﯿﻬﺷ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﺭﺎﯾﺩﺎﺘﺳﺍ،ﻝﺎﻔﻃﺍ<br />
ﺺﺼﺨﺘﻣ . 4<br />
87/<br />
11/<br />
9 : ﺐﯾﻮﺼﺗ ﺦﯾﺭﺎﺗ<br />
87/<br />
10/<br />
10 : ﺕﺎﺣﻼﺻﺍ ﺖﻬﺟ ﻉﺎﺟﺭﺍ ﺦﯾﺭﺎﺗ<br />
87/<br />
9/<br />
23 : ﺖﻓﺎﯾﺭﺩ<br />
ﺦﯾﺭﺎﺗ<br />
www.<strong>SID</strong>.ir
ﺎـﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ ﻥﺎﻧ ﺎﺑ ﺰﯿﻧ ﯽﻟﻮﮑﻟﻮﻣ و ﻞﻤﻋ ﻢﺴﯿﻧﺎﮑﻣ<br />
ﻪﺑﺎﺸـﻣ<br />
ﺎـﻬﻧﺁ ﮏﯿﺘﯿﻨﯿﮐﻮﮐﺎﻣﺭﺎﻓ ﻝﺎﺤﻨﯾﺍ ﺎﺑ . ﺪﻨﺷﺎﺑﯽﻣ<br />
ﺕوﺎﻔﺘﻣ<br />
ﺎـﻣﺍ ،ﺪـﻧﺭﺍﺩ<br />
ﯽﮐﺪـﻧﺍ یﺍﻩﺩوﺭ<br />
ﺏﺬـﺟ ﻪـﮑﻨﯾﺍ ﺎـﺑ ﻼﺜـﻣ . ﺖﺳﺍ<br />
ﻊـﻤﺠﺗ ﺎـﻫﻥﺍﻮﺨﺘـﺳﺍ<br />
ﺭﺩ و ﺖـﺳﺍ ﻻﺎـﺑ ﺎـﻬﻧﺁ ﯽﺑﺎﺨﺘﻧﺍ ﺕﺭﺪﻗ<br />
ﺭﺩ یﺪـﯾﺭو ﻖـﯾﺭﺰﺗﺯﺍ ﺪـﻌﺑ ﺖﻋﺎـﺳ ﮏـﯾ ﺎﺗ ﺎﺒﯾﺮﻘﺗ و ﺪﻨﺑﺎﯾﯽﻣ<br />
ﺭﺩ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﺕﺍﺮـﺛﺍ ( 9)<br />
ﺪـﻨﻧﺎﻣﯽﻣ<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ ، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
ﯽﻗﺎﺑ ﻥﺍﻮﺨﺘﺳﺍ<br />
. ﺖﺳﺍ ﻩﺪﻣﺁ 1 ﻩﺭﺎﻤﺷ ﻝوﺪﺟﺭﺩ ﻒﻠﺘﺨﻣ ﺕﺎﻌﻟﺎﻄﻣ<br />
O ═<br />
OH<br />
│<br />
P―<br />
│<br />
OH<br />
R1<br />
│<br />
C―<br />
│<br />
R2<br />
OH<br />
│<br />
P―<br />
│<br />
OH<br />
R1 R2<br />
Etidronate OH CH3<br />
Clodronate Cl Cl<br />
Tiludronate H CH2SPhenyl-Cl<br />
Pamidronate OH CH2CH2NH2<br />
Dimethyl pamidronate OH CH2CH2N(CH3)2<br />
Alendronate<br />
OH CH2CH2CH2NH2<br />
Ibandronate OH CH2CH2N(CH3)(Pentyl)<br />
Risedronate OH CH2-3-pyridine<br />
Zolendorate OH CH2(1H-imidazole-1-yl)<br />
(<br />
In Vitro<br />
═<br />
ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﺕﺎﺒﯿﮐﺮﺗ ﯽﯾﺎﯿﻤﯿﺷ ﺭﺎﺘﺧﺎﺳ<br />
O<br />
: 1 ﻩﺭﺎﻤﺷ ﻞﮑﺷ<br />
ﻂﯾﺍﺮﺷ)<br />
ﻩﺎﮕﺸﯾﺎﻣﺯﺁﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﺕﺍﺮﺛﺍ<br />
ﺲﯿـﺑ ﻪـﮐ ﺪـﻫﺩﯽـﻣ<br />
ﻥﺎﺸـﻧ ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ یﺎﻫﯽﺳﺭﺮﺑ<br />
ﺎﺑ)<br />
T یﺎﻫﻝﻮﻠﺳ<br />
ﺮﯿﺜﮑﺗ ﺪﻨﯾﺍﺮﻓ ﺭﺩ ﻝﻼﺘﺧﺍ ﺐﺒﺳ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
و ﺮـﯿﺜﮑﺗ ،(<br />
ﻥژ ﯽـﺘﻧﺁ ﻩﺪـﻨﻨﮐ ﻝﺎـﻌﻓ یﺎـﻫﻝﻮﻠـﺳ<br />
یوﺭ ﺮـﺛﺍ<br />
یﺎـﻫژﺎﻓوﺮﮐﺎﻣ ﺪـﯿﻟﻮﺗ ﺭﺩ ﻝﻼﺘـﺧﺍ و ژﺎـﻓوﺮﮐﺎﻣ ﺕﺮﺟﺎـﻬﻣ<br />
ﺭﺩ . ( 21)<br />
ﺪﻧﻮــﺷﯽــﻣ<br />
ﺯﻮــﺘﭘﻮﭘﺁ ﺪــﻨﯾﺁﺮﻓ و ﮏﯿﺴــﮐﻮﺗﻮﺘﯿﺳ<br />
ﻂﯿــﺤﻣ ﺭﺩ T یﺎــﻫﻝﻮﻠــﺳ<br />
ﻪــﮐ ﯽﻧﺎــﻣﺯ ﺮــﮕﯾﺩ یﺍﻪــﻌﻟﺎﻄﻣ<br />
10 ﻪـﺑ و ﺪﻧﺪـﺷ ﻩﺩﺍﺩ ﺖﺸـﮐ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﺎﺑ ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ<br />
ﺭﺩ یﺪـﯾﺭو ﻞﺧﺍﺩ ﻖﯾﺭﺰﺗ ﺯﺍ ﻪﻠﺻﺎﺣ ﺖﻈﻠﻏ ﺝوﺍ ﻪﻄﻘﻧ ﺮﺑﺍﺮﺑ<br />
T یﺎــﻫﻝﻮﻠــﺳ<br />
ﺦــﺳﺎﭘ ﺶﻫﺎــﮐ ،ﺪﻧﺪﯿــﺳﺭ<br />
ﻩﺪــﻧﺯ ﺩﻮــﺟﻮﻣ<br />
ﻥﺍﺰـﯿﻣ ﻪـﺑ ﺮﯿﺛﺎـﺗ ﻦﯾﺍ . ﺪﺷ ﺺﺨﺸﻣ ﺎﻫﻥژﻮﺘﯿﻣ<br />
ﻪﺑ ﻮﯿﺗﺍﺮﻔﯿﻟوﺮﭘ<br />
ﺎـﺑ ﻞـﯿﻟﺩ ﻦﯿﻤﻫ ﻪﺑ . ﺩﻮﺑ ﺎﻫﺖ<br />
ﯿﺳﻮﻧﻮﻣ<br />
ﻪﺑ ﻪﺘﺴﺑﺍو ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ<br />
ﺦـﺳﺎﭘ ﺖﺸـﮐ ﻢﺘﺴـﯿﺳ ﻪـﺑ ﻩﺯﺎـﺗ یﺎـﻫﺖﯿـﺳﻮﻧﻮﻣ<br />
ﻥﺩوﺰـﻓﺍ<br />
. ( 22)<br />
ﺪﯾﺩﺮﮔ ﺡﻼﺻﺍ T یﺎﻫﻝﻮﻠﺳ<br />
ﻮﯿﺗﺍﺮﻔﯿﻟوﺮﭘ<br />
ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﯽﺑﺎﻬﺘﻟﺍﺪﺿ ﺹﺍﻮﺧ<br />
ﺭﺩ ،ﺪﻨﻨﮐﯽﻣ<br />
ﺩﺎﺠﯾﺍ ﺍﺭ ،ﺩﺭﺍﺩ<br />
ﺩﻮﺟو ﺎﻫﻝﻮﻠﺳ<br />
ﻦﯿﺑ ﺭﺩ ﻪﮐ ﻪﭽﻧﺁ<br />
یﺎﻫﻢﯾﺰﻧﺁ<br />
ﺯﺍ ﯽﺧﺮﺑ ،ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻮﻨﯿﻣﺁ ﻥﺎﻧ<br />
ﺶـﻘﻧ و ﻩﺩﺮـﮐ ﻒﻗﻮﺘﻣ ﺍﺭ ( Mevalonate)<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻪﻠﺠﻣ<br />
ﻪﮐ ﯽﻟﺎﺣ<br />
ﺕﺎﻧﻮﻟﺍﻮﻣﺮﯿﺴﻣ<br />
ﺕﺭﺪـﻗ ﺪـﻨﻧﺎﻣ<br />
،ﻥﻮﮔﺎـﻧﻮﮔ<br />
ﯽﻟﻮﻠـﺳ ﻞـﺣﺍﺮﻣ ﻢﯿـﻈﻨﺗﺭﺩ ﯽﯾﺍﺰﺴﺑ<br />
-ﻥﺎـﻧ<br />
ﻝﺎـﻣوﺯﻮﭙﯿﻟ یﺎـﻫﻡﺮـﻓ<br />
. ﺪـﻧﺭﺍﺩ<br />
ﻝﻮﻠـﺳ ﺮﯿﺜﮑﺗ و<br />
ﺖﺴﯾﺯ<br />
ﮏـﯾﺮﺤﺗ ﺎﺑ ،ﺕﺎﻧوﺭﺩﻮﻠﮐ َﺎﺻﻮﺼﺨﻣ ،ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑﻮﻨﯿﻣﺁ<br />
ﺍﺭ ( ﺖﯾﻮﻨﯿـﺳ)<br />
ﻡﻮﯾﻮﻨﯿـﺳ ﺏﺎـﻬﺘﻟﺍ ،ﯽﺘﯿﺴﮐﻮﺗﻮﺘﯿﺳ ژﺎﻓوﺮﮐﺎﻣ<br />
یوﺭ ﻩﺪـﺷ ﻡﺎـﺠﻧﺍ ﯽـﮑﯿﻨﯿﻠﮐ ﺕﺎـﻌﻟﺎﻄﻣ . ﺪـﯾﺎﻤﻧﯽـﻣ<br />
ﺡﻼﺻﺍ<br />
ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﻪـﮐ ﻞـﺻﺎﻔﻣ ﯽﮑﺸﺧ و ﻡﺭﻮﺗ ﻪﺑ ﻼﺘﺒﻣ ﻥﺍﺭﺎﻤﯿﺑ<br />
ﻪـﺑ ﻪﺘﺴـﺑﺍو ﯽﺑﺎﻬﺘﻟﺍ ﺪﺿ ﺕﺍﺮﺛﺍ<br />
ﺪﯾﻮﻣ ،ﺪﻧﺩﻮﺑ ﻩﺩﻮﻤﻧ ﺖﻓﺎﯾﺭﺩ<br />
ﻦﻣﺰـﻣ ﺖـﯾﺮﺗﺭﺁ ﺎـﺑ ﻥﺍﺭﺎـﻤﯿﺑ ﺭﺩ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﺯوﺩ<br />
. ( 5-7)<br />
ﺖﺳﺍ<br />
: ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﮏﯿﺘﻨﯿﮐﻮﮐﺎﻣﺭﺎﻓ<br />
،ﺪﻨﺷﺎﺑﯽﻣ<br />
ﯽﻟﺁ ﺕﺎﻔﺴﻓوﺮﯿﭘ گﻮﻟﺎﻧﺁ<br />
ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ<br />
. ﺖﺳﺍ ﻩﺪﺷ ﻦﯾﺰﮕﯾﺎﺟ ﻦﺑﺮﮐ ﻢﺗﺍ ﮏﯾ ﺎﺑ ﻥﮋﯿﺴﮐﺍ ﻥﺁ ﺭﺩ ﻪﮐ<br />
ﺖـﯿﺗﺎﭘﺁ ﯽﺴـﮐوﺭﺪﯿﻫ ﺎـﺑ ﺍﺭ ﻪﺘﺴـﺑﺍو ﺹﺍﻮﺧ P-C-P ﻩوﺮﮔ<br />
ﺭﺩ ﻞﯿﺴـﮐوﺭﺪﯿﻫ ﻩوﺮﮔ ﺭﻮﻀﺣ ﻪﻄﺳﺍﻮﺑ ﻪﮐ ﺪﻫﺩﯽﻣ<br />
ﻖﯿﺒﻄﺗ<br />
ﺭﺩ ﻝﺎﺜﻣ ﺭﻮﻃ ﻪﺑ<br />
. ﺪﺑﺎﯾﯽ<br />
ﻣ ﺶﯾﺍﺰﻓﺍ ﺖﯿﺻﺎﺧ ﻦﯾﺍ R1 ﺖﯿﻌﻗﻮﻣ<br />
ﺖـﯿﻌﻗﻮﻣ ﺭﺩ ﻞﯿﺴﮐوﺭﺪﯿﻫ ﻩوﺮﮔ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ و ﺕﺎﻧوﺭﺪﯿﺗﺍ<br />
ﻞﮑـﺷ)<br />
ﺖـﺳﺍ ﻩﺪـﺷ<br />
ﯽـﯾوﺭﺍﺩ ﺕﺭﺪـﻗ ﺶﯾﺍﺰـﻓﺍ ﺐﺒـﺳ<br />
ﺏﺬـﺟﺯﺎﺑ ﻥﺩﺮﮐ ﻒﻗﻮﺘﻣ ﺭﺩ ﻞﻣﺍﻮﻋ ﻦﯾﺍ ﺕﺭﺪﻗ . ( 1<br />
،ﺪـﺷﺎﺑﯽـﻣ<br />
ﻪﺘﺴﺑﺍو<br />
R2<br />
R1<br />
ﻩﺭﺎﻤﺷ<br />
ﻩﺮﯿﺠﻧﺯ ﯽﺒﻧﺎﺟ ﺶﺨﺑ ﻪﺑ ﺰﯿﻧ ﻥﺍﻮﺨﺘﺳﺍ<br />
ﺭﺩ ﻥژوﺮـﺘﯿﻧ ﻢﺗﺍ ﮏﯾ یﺍﺭﺍﺩ ﻪﮐ ﯽﯾﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻩﮋﯾﻮﺑ<br />
ﺹﺎـﺧ ﯽﯾﺎﻀـﻓ ﻞﮑـﺷ ﺎﺑ P-C-P ﻩوﺮﮔ ﺯﺍ ﯽﺳﺎﺴﺣ ﻪﻠﺻﺎﻓ<br />
ﺲﯿــﺑ ﺯﺍ ﺮــﺗیﻮــﻗ<br />
ﯽﻬﺟﻮــﺗ ﻞــﺑﺎﻗ ﻥﺍﺰــﯿﻣ<br />
ﻪــﺑ ،ﺪﻨــﺷﺎﺑﯽــﻣ<br />
ﻝﺎــﺜﻣ یﺍﺮــﺑ . ( 8)<br />
ﺪﻨﺘﺴــﻫ<br />
ﻥژوﺮــﺘﯿﻧ ﺪــﻗﺎﻓ یﺎــﻫﺕﺎﻧﻮﻔﺴــﻓ<br />
ﻥژوﺮـﺘﯿﻧ ﻢـﺗﺍ ﮏـﯾ یﺍﺭﺍﺩ ﻪـﮐ ﺕﺎﻧوﺭﺪﻨﻟ ﺁ و ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
100ﺎـﺗ<br />
10 ،ﺪﻨﺘﺴـﻫ<br />
ﻞـﯿﮑﻟﺍ ﻩﺮـﯿﺠﻧﺯ ﺭﺩ ﻪﻄﺳﺍوﯽﺑ<br />
و یﺍﻪﯾﺎﭘ<br />
،ﺪﻨـﺷﺎﺑﯽـﻣ<br />
ﺕﺎـﻧوﺭﺩﻮﻠﮐ ﺎـﯾ ﺕﺎﻧوﺭﺪـﯿﺗﺍ ﺯﺍ ﺮـﺗیﻮـﻗ<br />
ﺮـﺑﺍﺮﺑ<br />
،ﺕﺎﻧوﺭﺪــﻧﺎﺒﯾﺍ)<br />
ﻪــﻧﺎﮔ ﻪــﺳ ﻥژوﺮــﺘﯿﻧ یﺍﺭﺍﺩ ﻪــﮐ ﯽﻠﻣﺍﻮــﻋ<br />
ﺭﺎــﻬﻣ ﺭﺩ ﯽــﺘﺣ ﺪﻨﺘﺴــﻫ ( ﺕﺎﻧوﺭﺪــﻨﻟوﺯ<br />
و ﺕﺎﻧوﺭﺪﯿــﺳﺍ<br />
ﺲﯿﺑﻮـﻨﯿﻣﺁ . ﺪـﻨﻨﮐﯽـﻣ<br />
ﻞﻤﻋ ﺮﺗیﻮﻗ<br />
ﺰﯿﻧ ﻥﺍﻮﺨﺘﺳﺍ ﺏﺬﺟﺯﺎﺑ<br />
ﺮـﻈﻧ ﺯﺍ ﻪـﮑﻠﺑ ،ﯽﺑﺬـﺟﺯﺎﺑ<br />
ﺕﺭﺪﻗ ﺮﻈﻧ ﺯﺍ ﺎﻬﻨﺗ ﻪﻧ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
www.<strong>SID</strong>.ir<br />
80
ﻥﺍﺭﺎﮑﻤﻫ و یﺭﺎﯿﺷ ﺎﺿﺭ<br />
81<br />
TNF-a<br />
-<br />
-<br />
-<br />
-<br />
ﺶﻫﺎﮐ<br />
ﺶﻫﺎﮐ<br />
ﺶﻫﺎﮐ<br />
ﺶﻫﺎﮐ<br />
ﺶﯾﺍﺰﻓﺍ<br />
ﺶﯾﺍﺰﻓﺍ<br />
ﺶﯾﺍﺰﻓﺍ<br />
ﺕﺎـﻌﻟﺎﻄﻣ<br />
ﻦـﯾﺍ<br />
ﻪﻌﻟﺎﻄﻣ ﺭﺩ ﯽﺳﺭﺮﺑ ﺩﺭﻮﻣ ﺭﻮﺘﮐﺎﻓ<br />
IL-6<br />
* -<br />
ﺮﯿﺛﺎﺗ ﻥوﺪﺑ<br />
-<br />
ﺶﻫﺎﮐ<br />
ﺶﻫﺎﮐ<br />
-<br />
-<br />
-<br />
ﺶﯾﺍﺰﻓﺍ<br />
-<br />
. ﺖـﺳﺍ ﻩﺩﻮـﺑ<br />
R2<br />
IL-1<br />
ﺶﻫﺎﮐ<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ<br />
، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
-<br />
ﺶﯾﺍﺰﻓﺍ<br />
-<br />
ﺶﻫﺎﮐ<br />
-<br />
ﺶﻫﺎﮐ<br />
ﺶﻫﺎﮐ<br />
ﺶﯾﺍﺰﻓﺍ<br />
ﺶﯾﺍﺰﻓﺍ<br />
ﺶﯾﺍﺰﻓﺍ<br />
ﺯﺍ ﺎﻫﺖﯿﺳﻮﻧﻮﻣ<br />
ﺮﺑ ﺍﺭ ﺩﻮﺧ ﺮﺛﺍ ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﻩﺮـﯿﺠﻧﺯ ﺭﺍﺩ ﯽـﺑﺮﭼ ﻩﺭﺎﻨﮐ<br />
ﻪﮐ ﺪﻫﺩﯽﻣ<br />
ﻥﺎﺸﻧ<br />
IL-1 ﻂـﺳﻮﺗ ﺪـﻧﺍﻮﺗﯽﻣ<br />
ﻪﮐ ﺪﻨﮐﯽﻣ<br />
ﺍﺮﺟﺍ ﯽﻤﺴﯿﻧﺎﮑﻣ ﻖﯾﺮﻃ<br />
ﺕﺎﺸـﯾﺎﻣﺯﺁ ﺭﺩ ﺕﺎﻧوﺭﺪـﻨﻟﺁ<br />
. ( 24)<br />
ﺩﻮـﺷ ﻩﺩﺮﺑ ﺶﯿﭘ ﻥژوﺰﮔﺍ<br />
ﺮـﺑﺍﺮﺑ 10 ﻞﻗﺍﺪـﺣ ،ﻥﺍﻮﺨﺘـﺳﺍ<br />
ﺏﺬـﺟ ﺯﺎـﺑ ﮏﯿﺘﺳﻼﮐﻮﺌﺘﺳﺍ<br />
ﺕﺍﺮـﺛﺍ ،ﻩوﻼـﻋ ﻪﺑ<br />
. ﺖﺳﺍ ﻩﺪﺷ ﺮﻫﺎﻇ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ ﺯﺍ ﺮﺗیﻮﻗ<br />
ﻩﺪـﺷ ﺱﻮﮑﻌﻣ IL1β<br />
ﺶﯾﺍﺰﻓﺍ ﻂﺳﻮﺗ ﺕﺎﻧوﺭﺪﻨﻟﺁ ﻩﺪﻧﺭﺍﺩﺯﺎﺑ<br />
ﭻﯿﻫ ،ﻦﯾﺍ ﺩﻮﺟو ﺎﺑ . ﺩﻮﺷﯽﻣ<br />
IL-1 ﺢﺷﺮﺗ<br />
ﻒﻗﻮﺗ ﻪﺑ ﺮﺠﻨﻣ و<br />
یوﺭ ﺎــﻫﺕﺎﻧﻮﻔﺴــﻓ<br />
ﺲﯿــﺑ ﻢﯿﻘﺘﺴــﻣ ﺮــﺛﺍﺮﺑ<br />
ﻝﺍﺩ یﺍﻪــﺘﻓﺎﯾ<br />
ﺲﯿﺑ ﺕﺍﺮﺛﺍ ﺮﯿﺧﺍ ﺕﺎﻌﻟﺎﻄﻣ . ( 25)<br />
ﺪﺸﻧ ﻩﺪﻫﺎﺸﻣ T یﺎﻫﻝﻮﻠﺳ<br />
ﺩﻮـﺟﻮﻣ ﺭﺩ ﯽﺑﺎـﻬﺘﻟﺍ<br />
ﺎـﻫﻦﯿﮐﻮﺘﯿـﺳ<br />
ﺪـﯿﻟﻮﺗﺭﺩ ﺍﺭ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
یﺭﺎـﻬﻣ ﺮﺛﺍ ﺪﯾﻮﻣ ﺕﺎﻌﻟﺎﻄﻣ ﺮﺜﮐﺍ<br />
. ﺖﺳﺍ ﻩﺩﻮﻤﻧ ﯽﺳﺭﺮﺑ ﻩﺪﻧﺯ<br />
ﯽـﻓﺮﻃ ﺯﺍ . ﺪﻨﺘﺴـﻫ ﺎـﻫﻦﯿﮐﻮﺘﯿﺳ<br />
ﺪﯿﻟﻮﺗ ﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ<br />
ﺍﺭ ﺎـﻫﻦﯿﮐﻮﺘﯿـﺳ<br />
ﺪـﯿﻟﻮﺗ ﺶﯾﺍﺰـﻓﺍ یﺩﺪﻌﺘﻣ<br />
ﺕﺎﺷﺭﺍﺰﮔ ﺮﮕﯾﺩ<br />
ﺎـﺑ ﯽﯾﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﻮـﻨﯿﻣﺁ ﻂـﺳﻮﺗ ،ﺏﺎـﻬﺘﻟﺍ<br />
ﺯﺍ ﺲـﭘ<br />
یﺎـﻫﺕوﺎـﻔﺗ<br />
. ﺪـﻧﺍﻩﺩﻮـﻤﻧ<br />
ﺡﺮـﻄﻣ ﯽﻣوﺯﻮـﭙﯿﻟ یﺎـﻫﻝﻮﺴـﭙﮐ<br />
ﺎـﻫ<br />
ﺕﺎﻧﻮﻔﺴـﻓ ﺲﯿﺑﻮـﻨﯿﻣﺁ ﺕﺍﺮـﺛﺍ ﺩﺭﻮـﻣ ﺭﺩ ﻩﺪـﺷ ﺵﺭﺍﺰـﮔ<br />
. ﺪﺷﺎﺑﯽﻣ<br />
ﺕﺎﻌﻟﺎﻄﻣ ﻉﻮﻧ ﺭﺩ ﻑﻼﺘﺧﺍ ﻞﯿﻟﺩ ﻪﺑ<br />
ٌﻻﺎﻤﺘﺣﺍ<br />
،ﺕﺎــﻧوﺭﺩﻮﻠﮐ ﻪــﮐ ﻩﺩﺍﺩ ﻥﺎﺸــﻧ ﺮﺘﺸــﯿﺑ یﺎــﻫﯽــﺳﺭﺮﺑ<br />
TNF-α ، IL-1 ﺢــﺷﺮﺗ ﻊﻧﺎــﻣ ﺕﺎﻧوﺭﺪــﻨﻟﺁ و ﺕﺎﻧوﺭﺪــﯿﺗﺍ<br />
ﯽﻧﺎﺴـﻧﺍ<br />
ﺖـﺳﻼﺑﻮﺌﺘﺳﺍ یﺎـﻫﻝﻮﻠـﺳ<br />
ﻂـﺳﻮﺗ IL-6 ﺪـﯿﻟﻮﺗ و<br />
یﺎـﻫﺯوﺩ ﺮـﺛﺍ ﻪـﮐ ﺕﺎـﻌﻟﺎﻄﻣ ﻦـﯾﺍ ﻞـﺑﺎﻘﻣ ﺭﺩ . ( 26)<br />
ﺪﻧﻮﺷﯽﻣ<br />
ﻪﻌﻟﺎﻄﻣ ﻉﻮﻧ<br />
Invitro<br />
Invitro<br />
ﯽﻧﺍﻮﯿﺣ<br />
Invitro<br />
Invitro<br />
ﯽﻨﯿﻟﺎﺑ ﯽﯾﺎﻣﺯﺁﺭﺎﮐ<br />
ﯽﻧﺍﻮﯿﺣ<br />
Invitro<br />
Invitro<br />
Invitro<br />
Invitro<br />
یﺭوﺮــﻣ<br />
ﺎﻫ ﻦﯿﮐﻮﺘﯿﺳ یوﺭ ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﺩﺮﮑﻠﻤﻋ ﺖﯿﻌﺿو : 1 ﻩﺭﺎﻤﺷ ﻝوﺪﺟ<br />
ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﻉﻮﻧ<br />
ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﺕﺎﻧوﺭﺪﻟوﺯ و ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﺕﺎﻧوﺭﺪﯿﺗﺍ<br />
ﺕﺎﻧوﺭﺪﯿﺗﺍ<br />
ﺕﺎﻧوﺭﺪﯾﺯﺭ<br />
ﺕﺎﻧوﺭﺩﺎﺒﯾﺍ<br />
ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﺕﺎﻧوﺭﺪﻨﻟﺁ<br />
ﻪﻌﻟﺎﻄﻣ<br />
Deng X, et al (10)<br />
Naidu A, et al (11)<br />
Buduneli E, et al (12)<br />
Yamamoto K, et al (13)<br />
Suzuki Y, et al (14)<br />
D'Amelio P, et al (15)<br />
Bianchi M, et al (16)<br />
Epstein H, et al (17)<br />
Deng X, et al (18)<br />
Toyras A, et al (19)<br />
Pietschmann P, et al (20)<br />
( ﻪﻌﻟﺎﻄﻣ ﺭﺩ ﺭﻮﺘﮐﺎﻓ ﯽﺳﺭﺮﺑ ﻡﺪﻋ :* )<br />
ﺭﺎﯿﺴـﺑ ﻥﻮـﺧ ﺵﺩﺮـﮔ ﺭﺩ ﺎـﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﺮﻤﻋ ﻪﻤﯿﻧ<br />
ﯽﺴﮐوﺭﺪﯿﻫ ﻪﺑ ﻥﺪﯿﺒﺴﭼ یﺍﺮﺑ یﺩﺎﯾﺯ ﻞﯾﺎﻤﺗ و ﺖﺳﺍ ﻩﺎﺗﻮﮐ<br />
ﺲﯿــﺑ ﺯﺍ ﯽــﺧﺮﺑ ،ﻩوﻼــﻋ<br />
ﻪــﺑ<br />
. ﺪــﻧﺭﺍﺩ ﻥﺍﻮﺨﺘــﺳﺍ ﺖــﯿﺗﺎﭘﺁ<br />
ﺏﺁ ﺭﺩ ﻝﻮـﻠﺤﻣ ( ﺕﺎـﻧوﺭﺩﻮﻠﮐ ﻝﺎـﺜﻣ ﺭﻮـﻄﺑ)<br />
ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺍﺪـﺘﺑﺍ ﺭﺩ و ﺪﻧﻮـﺷﯽـﻤﻧ<br />
ﺶـﺨﭘ ﺎﻫﻝﻮﻠﺳ<br />
ﺭﺩ ﯽﺘﺣﺍﺮﺑ و ﺖﺳﺍ<br />
ﺖـﺤﺗ ﺎـﻫژﺎﻓوﺮﮐﺎﻣ و ﺎـﻫﺖـﺳﻼﮐﻮﺌﺘﺳﺍ<br />
ﻂﺳﻮﺗ ﺖﺴﯾﺎﺑﯽﻣ<br />
. ﺪﻧﻮـﺷ ﺏﺬـﺟ ﻥﺍﻮﺨﺘﺳﺍﺭﺩ<br />
ﯽﻧﺪﻌﻣ ﺩﺍﻮﻣ ﺎﯾ ﻦﻫﺁ ﺎﺑ ﺐﯿﮐﺮﺗ<br />
ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ ﻂﯾﺍﺮﺷﺭﺩ<br />
ﻩﺪﻣﺁ ﺖﺳﺪﺑ ﺕﺎﻋﻼﻃﺍ ﯽﻠﮐ ﺭﻮﻄﺑ<br />
ﻪﺘـﺳﺩ وﺩ ﻪـﺑ ﻥﺍﻮـﺗﯽـﻣ<br />
ﺍﺭ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿﺑ ﺹﻮﺼﺧ ﺭﺩ<br />
ﻪـﮐ ﺖـﺳﺍ<br />
ﻥﺁ ﺪـﯾﻮﻣ ﻝوﺍ ﻪﺘـﺳﺩ ﺕﺎـﻋﻼﻃﺍ : ﺩﺮـﮐ ﻢﯿﺴـﻘﺗ<br />
ﺮـﯿﯿﻐﺗ ﺮـﺑ ﯽﻤﯿﻘﺘﺴـﻣ ﻩﺪـﻧﺭﺍﺩﺯﺎﺑ ﺮـﺛﺍ ﺪـﻧﺍﻮﺗﯽـﻣ<br />
ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﻡوﺩ ﻪﺘـﺳﺩ ﺕﺎـﻋﻼﻃﺍ ﯽـﻟو<br />
ﺪـﺷﺎﺑ ﻪﺘﺷﺍﺩ ﺎﻫﺖﯿﺳﻮﻔﻨﻟ<br />
ﻞﮑﺷ<br />
ﺕﺭﺪـﻗ ﺶﻫﺎـﮐ ﺮﺑ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻢﯿﻘﺘﺴﻣ ﺮﯿﻏ<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻪﻠﺠﻣ<br />
ﺮﺛﺍ ﺪﯾﻮﻣ<br />
ﺎﻫﺖﯿﺳﻮﻔﻨﻟ<br />
ﺮﯿﺜﮑﺗ ﻉوﺮﺷﺭﺩ ﺎﻬﻧﺁ<br />
ﺶﻘﻧ و ﯽﺘﯿﺳﻮﻧﻮﻣ ﺖﺴﯾﺯ<br />
ﺕﺎـﻧوﺭﺩﻮﻠﮐ . ﺪـﺳﺭﯽـﻣ<br />
ﺮـﻈﻧ ﻪـﺑ ﺮـﺗ ﻞـﻤﺘﺤﻣ ﻪـﮐ ﺪﺷﺎﺑﯽﻣ<br />
ﺮـﯿﺜﮑﺗ ﺮـﺑ ﺍﺭ ﺩﻮﺧ ﺕﺍﺮﺛﺍ و ﺖﺳﺍ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ ﺯﺍ ﺮﺗﻒﯿﻌﺿ<br />
ﻢﺴـــﯿﻧﺎﮑﻣ ﮏـــﯾ ﻖـــﯾﺮﻃ ﺯﺍ ژﺎـــﻓوﺮﮐﺎﻣ / ﺖﯿـــﺳﻮﻧﻮﻣ<br />
ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﻪـﮐﯽﻟﺎـﺣ<br />
ﺭﺩ ،ﺪﯾﺎﻤﻧﯽﻣ<br />
ﺍﺮﺟﺍ ﮏﯿﺴﮐﻮﺗﻮﺘﯿﺳ<br />
. ( 23)<br />
ﺩﻮـﺷﯽـﻣ<br />
ﯽﻟﻮﻠﺳ ﺮﯿﺜﮑﺗ ﻊﻧﺎﻣ ﮏﯿﺴﮐﻮﺗ<br />
ﺮﯿﻏ یﺯوﺩ ﺭﺩ<br />
ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻮﻨﯿﻣﺁ ﺎﺑ و ﺖﺳﺍ ﺯوﺩ ﻪﺑ ﻪﺘﺴﺑﺍو ﺕﺍﺮﺛﺍ ﻦﯾﺍ<br />
ﺰﯿﻟﺎـﻧﺁ ﻦﯿـﻨﭽﻤﻫ . ﺪـﺷﯽـﻣ<br />
ﺮﻫﺎـﻇ ﺕﺎـﻧوﺭﺩﻮﻠﮐ ﺯﺍ ﺮـﺗﻊﯾﺮﺳ<br />
ﻝﻮـﻃ و ﺕﺭﺪﻗ ﻦﯿﺑ ﻁﺎﺒﺗﺭﺍ ﻩﺪﻨﻫﺩ ﻥﺎﺸﻧ ،ﺖﯿﻟﺎﻌﻓ<br />
یﺭﺎﺘﺧﺎﺳ<br />
www.<strong>SID</strong>.ir
. ﺪـﯾﺎﻤﻧﯽـﻣ<br />
ﺖـﻌﻧﺎﻤﻣ IL-6 یﺯﺎـﺳﺩﺍﺯﺁ ﺯﺍ PTH ﺎـﺑ ﻩﺍﺮـﻤﻫ<br />
ﺭﺩ ﺍﺭ IL-6 ﺪـﯿﻟﻮﺗ PTH ﻪﮐ ﺩﻮﺑ ﻩﺩﺍﺩ ﻥﺎﺸﻧ ﯽﻠﺒﻗ ﺕﺎﻌﻟﺎﻄﻣ<br />
ﮏﮑﺸـﮐ ﻥﺍﻮﺨﺘﺳﺍ ﻝﺎﻣوﺮﺘﺳﺍ یﺎﻫﻝﻮﻠﺳ<br />
و ﺎﻫﺖﺳﻼﺑﻮﺌﺘﺳﺍ<br />
ﺖـﺳﺍ ﻥﺁ ﺯﺍ ﯽﮐﺎـﺣ ﺕﺎﻋﻼﻃﺍ ﻦﯾﺍ . ( 31)<br />
ﺪﯾﺎﻤﻧﯽﻣ<br />
ﮏﯾﺮﺤﺗ<br />
،ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﻥﺎـﻣﺭﺩ ﻪـﺑ ﺦـﺳﺎﭘ ﺭﺩ IL-6 ﻊـﺒﻨﻣ ﻪـﮐ<br />
ﻪـﮐ ﺩﻮـﺷﯽـﻣ<br />
ﺭﻮﺼـﺗ ﺭﻮـﻃﻦ<br />
ﯾﺍ ﻦﯾﺍﺮﺑﺎﻨﺑ . ﺪﺷﺎﺑﯽﻣ<br />
ﻥﺍﻮﺨﺘﺳﺍ<br />
ﻂـﺳﻮﺗ ﻪـﮐ ﺕﺎﻧﻮﻔﺴـﻓ ﺲﯿـﺑ ﻢـﮐ ﺮﯾﺩﺎـﻘﻣ ﺖـﺳﺍ ﻦـﮑﻤﻣ<br />
یﺯﺎــﺳﺩﺍﺯﺁ ﮏــﯾﺮﺤﺗ یﺍﺮــﺑ ،ﺩﻮــﺷﯽــﻣ<br />
ﺩﺍﺯﺁ ﻥﺍﻮﺨﺘــﺳﺍ<br />
. ﺪﺷﺎﺑ ﯽﻓﺎﮐ IL-6 ﯽﻌﺿﻮﻣ<br />
ﺯﺍ ﻩﺩﺎﻔﺘـﺳﺍ ﻪـﮐ ﻩﺩﺍﺩ ﻥﺎﺸـﻧ ﺮـﮕﯾﺩ ﯽﮑﯿﻨﯿﻠﮐ ﺕﺎﻌﻟﺎﻄﻣ<br />
ﻩﺍﺮﻤﻫ IL-6 و TNF-α یﺮﯿﮕﻤﺸﭼ ﺶﯾﺍﺰﻓﺍ ﺎﺑ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺎـﺑ ﻖﺑﺎـﻄﻣ<br />
. ﺖﺴـﯿﻧ ﻪـﻧﻮﮕﻨﯾﺍ IL-1 ﺩﺭﻮـﻣ ﺭﺩ ﯽـﻟو ،ﺖـﺳﺍ<br />
ﺵوﺍﺮـﺗ ﺐـﺟﻮﻣ ﺕﺎـﻧوﺭﺩﻮﻠﮐ ،ﯽﻫﺎﮕﺸـﯾﺎﻣﺯﺁ<br />
ﺕﺎـﻋﻼﻃﺍ<br />
ﺕﺎﻧوﺭﺪـﻧﺎﺒﯾﺭ ،ﺕﺍﺭﺎـﻈﺘﻧﺍ ﻑﻼﺧﺮﺑ ﺎﻣﺍ ﺩﻮﺷ ﯽﻤﻧ ﻦﯿﮐﻮﺘﯿﺳ<br />
ﺶﺠﻨﺳ ﺭﺩ ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ ﻥﺍﺰﯿﻣ ﻪﺑ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ و<br />
ﺯﺍ ﺮـــﺗ یﻮـــﻗ ﮏﯿﺘـــﺳﻼﮐﻮﺌﺘﺳﺍ ﯽﻧﺍﻮﺨﺘـــﺳﺍ<br />
ﺏﺬـــﺟﺯﺎﺑ<br />
ﻥﺎﺸـﻧ ﺕﺎـﻋﻼﻃﺍ ﻦـﯾﺍ ﻪـﭼﺮﮔﺍ . ( 32)<br />
ﺪﻨـﺷﺎﺑﯽﻣ<br />
ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﻪﮐ ﯽﻧﺍﺭﺎﻤﯿﺑ ﺭﺩ ﺎﻫﻦﯿﮐﻮﺘﯿﺳ<br />
ﻊﺒﻨﻣ ﻪﮐ ﺪﻫﺩﯽﻣ<br />
ﻦﮐﺎـﺳ یﺎﻫﻝﻮﻠﺳ<br />
ﺎﻬﻨﺗ ﻪﻧ<br />
،ﺪﻧﺍﻩﺩﺮﮐ<br />
ﺖﻓﺎﯾﺭﺩ یﺪﯾﺭو ﻞﺧﺍﺩ<br />
ﺭﺩ ﺩﻮـﺟﻮﻣ یﺎـﻫﻝﻮﻠـﺳ<br />
ًﻻﺎـﻤﺘﺣﺍ ﻪﮑﻠﺑ ﺖﺳﺍ ﻥﺍﻮﺨﺘﺳﺍ ﺭﺩ<br />
ﻦـﯾﺍ ﻦﯿـﻨﭽﻤﻫ . ﺪـﺷﺎﺑﯽـﻣ<br />
ﻦﯿﮐﻮﺘﯿـﺳ ﻊﺒﻨﻣ ﺰﯿﻧ ﻥﻮﺧ ﺵﺩﺮﮔ<br />
ﻦﯿــﺑ ﯽﻨــﺳ ﯽﯾﺎــﻧﺍﻮﺗ ﺭﺩ<br />
ﺕوﺎــﻔﺗ ﺩﻮــﺟو ﻝﺎــﻤﺘﺣﺍ ﻪــﻌﻟﺎﻄﻣ<br />
ﻦﯿﮐﻮﺘﯿـﺳ<br />
ﺵوﺍﺮـﺗ ﺐـﯿﻏﺮﺗ<br />
ﺖـﻬﺟ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ<br />
ﺎـﻬﻧﺁ ﺏﺬـﺟ ﺪـﺿ ﯽﯾﺎـﻧﺍﻮﺗ ﻑﻼﺧﺮـﺑ ﺍﺭ ﺏﺎـﻬﺘﻟﺍ<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ ، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
ﺯﺍ ﻞـﺒﻗ<br />
ﻩﺩﺎﻔﺘـﺳﺍ ﺭﺩ ﻪـﻟﺎﻘﻣ ﻥﺎﮔﺪﻨﺴـﯾﻮﻧ ﺕﺎﻌﻟﺎﻄﻣ . ﺪﻫﺩﯽﻣ<br />
ﺶﯾﺍﺰﻓﺍ<br />
یﺎـﻫیﺭﺎـﻤﯿﺑ<br />
ﻪـﺑ ﻼﺘـﺒﻣ ﻥﺎـﮐﺩﻮﮐ ﺭﺩ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿﺑﺯﺍ<br />
ﺖــﻬﺟ ﺭﺩ ﻢــﻫ ﺕﺎــﺒﯿﮐﺮﺗ ﻦـﯾﺍ ﺮﯿﺛﺎــﺗ ﺪــﯾﻮﻣ ﯽﻤﺴـﯿﺗﺎﻣوﺭ<br />
ﻢـﻫ و ﯽﻨﭘﻮﯿﺘـﺳﺍ ﺩﻮـﺒﻬﺑ ﺐـﻗﺎﻌﺘﻣ ﻥﺍﻮﺨﺘـﺳﺍ ﻢﮐﺍﺮﺗ ﺶﯾﺍﺰﻓﺍ<br />
( وﺭﺍﺩ ﯽﺑﺎـﻬﺘﻟﺍ ﺪﺿ ﺕﺍﺮﺛﺍ ﻞﯿﻟﺩ ﻪﺑ)<br />
یﺍﻪﻨﯿﻣﺯ<br />
یﺭﺎﻤﯿﺑ ﻝﺮﺘﻨﮐ<br />
. ( 33،5)<br />
ﺖﺳﺍ ﻩﺩﻮﺑ<br />
ﻦﯿﮐﻮﺘﯿـﺳ ﺡﻮﻄـﺳ ﯽﻨﯿﻟﺎـﺑ ﯽﯾﺎـﻣﺯﺁﺭﺎﮐ ﻪـﻌﻟﺎﻄﻣ وﺩ ﺭﺩ<br />
ﺪــﯿﺋﻮﺗﺎﻣوﺭ ﺎــﺑ ﻥﺍﺭﺎــﻤﯿﺑ ﺭﺩ ﺏﺎــﻬﺘﻟﺍ ﺯﺍ ﺪــﻌﺑ و ﻞــﺒﻗ ﻡﺮــﺳ<br />
ﯽﺑﺎـﯾﺯﺭﺍ ﺩﺭﻮـﻣ ﺕﺎﻧﻮﻔﺴـﻓ ﺲﯿـﺑ ﺎـﺑ ﻥﺎﻣﺭﺩ ﺖﺤﺗ ﺖﯾﺮﺗﺭﺁ<br />
ﻡﺮـﮔ ﯽـﻠﯿﻣ<br />
300 ﻥﺍﺭﺎـﻤﯿﺑ ﺖﺴﺨﻧ ﻪﻌﻟﺎﻄﻣ ﺭﺩ . ﺖﻓﺮﮔ ﺭﺍﺮﻗ<br />
ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﯽﺑﺎﻬﺘﻟﺍﺪﺿ ﺹﺍﻮﺧ<br />
ﻩﺪـﺷ ﻩﺩﺍﺩ ﺖﺸـﮐ یﺎـﻫﻝﻮﻠـﺳ<br />
ﺭﺩ ﺍﺭ ﺩﺍﺯﺁ یﺎﻫوﺭﺍﺩ یﻻﺎﺑ<br />
ﯽﻣوﺯﻮـﭙﯿﻟ یﺎـﻫﻡﺮﻓ<br />
ﺰﯿﻧ ﺵﺭﺍﺰﮔ ﻦﯾﺪﻨﭼ ،ﺪﻨﻨﮐﯽﻣ<br />
ﯽﺳﺭﺮﺑ<br />
ﻪـﮐ ﺩﺍﺩ ﻥﺎﺸـﻧ ﺕﺎـﻌﻟﺎﻄﻣ ﻦـﯾﺍ . ﺪﻧﺩﺍﺩ ﺭﺍﺮﻗ ﯽﺑﺎﯾﺯﺭﺍ ﺩﺭﻮﻣ ﺍﺭ<br />
ﺲﯿــﺑ ﯽــﺧﺮﺑ ﺭﺩ ﻩﺪــﺷ ﻝﺎــﻌﻓ یﺎــﻫﺖﯿــﺳﻮﻧﻮﻣ<br />
ﺭﻮﻀــﺣ<br />
و IL-6 ،IL-1<br />
ﺪـﯿﻟﻮﺗ ،(<br />
ﺎـﻬﻧﺁ<br />
ﻪـﻤﻫ ﻪـﻧ ﻪـﺘﺒﻟﺍ)<br />
ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺖﺳﺍ<br />
ﻩﺪﺷ ﻥﺎﯿﺑ ﻪﻌﻟﺎﻄﻣ ﮏﯾ ﺭﺩ . ﺪﻨﻫﺩﯽﻣ<br />
ﺶﯾﺍﺰﻓﺍ ﺍﺭ<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻪﻠﺠﻣ<br />
TNF<br />
ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ ﻥﺎﻧ و ﻮﻨﯿﻣﺁ ﺕﺍﺮﺛﺍ ﺖﺳﺍ ﻦﮑﻤﻣ ﻪﮐ<br />
ﺕوﺎـﻔﺘﻣ ﻢـﻫ ﺎـﺑ ﯽﺑﺎـﻬﺘﻟﺍ<br />
ﺶﯿـﭘ یﺎﻫﻦﯿﮐﻮﺘﯿﺳ<br />
ﺢﺷﺮﺗ یوﺭ<br />
ﻪـــﻠﻤﺟ ﺯﺍ ،ﺎـــﻫﺕﺎﻧﻮﻔﺴـــﻓ<br />
ﺲﯿﺑﻮـــﻨﯿﻣﺁ ﻥﺎـــﻧ . ( 27)<br />
ﺪـــﺷﺎﺑ<br />
و ژﺎـﻓوﺮﮐﺎﻣ ﻪﺒـﺷ یﺎﻫﻝﻮﻠﺳ<br />
ﻂﺳﻮﺗ ﺪﻨﻧﺍﻮﺗﯽﻣ<br />
ﺕﺎﻧوﺭﺩﻮﻠﮐ<br />
ﻂـﺳﻮﺗ یﺍﻪـﯾﺰﺠﺗ<br />
ﺶﻨﮐﺍو ﺭﺩ ﺖﺳﻼﺑﻮﺌﺘﺳﺍ ﻪﺒﺷ یﺎﻫﻝﻮﻠﺳ<br />
ﻪـﮐ ATP ﻦﯿﻠﯿﺘﻣ<br />
یوﺎﺣ یﺎﻫگﻮﻟﺎﻧﺁ<br />
ﻪﺑ tRNA یﺎﻫﺰﺘﻨﺳ<br />
ﻦــﯾﺍ . ( 28)<br />
ﺪﻧﻮــﺷ ﻩﺰﯿﻟﻮﺑﺎــﺘﻣ ،ﻩﺩﻮــﺑ<br />
ﺰﯿﻟوﺭﺪــﯿﻫ ﻞــﺑﺎﻗ ﺮــﯿﻏ<br />
ﻪﺘـﺳﺩ وﺩ ﻪﺑ ﺍﺭ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻪﮐ ﻩﺪﺷ ﺐﺒﺳ ﺕﺍﺪﻫﺎﺸﻣ<br />
ﺲﯿﺑﻮـﻨﯿﻣﺁ ﻥﺎـﻧ و ﯽﺑﺎـﻬﺘﻟﺍ<br />
ﺶﯿـﭘ یﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ<br />
. ﺪﻨﯾﺎﻤﻧ<br />
ﻢﯿﺴﻘﺗﺰﯿﻧ<br />
ﺏﺎﻬﺘﻟﺍﺪﺿ یﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
(<br />
In Vivo<br />
ﻂﯾﺍﺮﺷ)<br />
ﻩﺪﻧﺯ ﺩﻮﺟﻮﻣﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓﺲﯿﺑ<br />
ﺕﺍﺮﺛﺍ<br />
یﺎـﻫﺯوﺩ<br />
ﻪﮐ ﻩﺩﺍﺩ ﻥﺎﺸﻧ ﯽﺗﺎﻣﺪﻘﻣ یﺎﻫﯽﺳﺭﺮﺑ<br />
ﻪﭼﺮﮔﺍ<br />
ﺩﻮـﺒﻬﺑ ﺐﺒـﺳ ﯽﻫﺎﮕﺸـﯾﺎﻣﺯﺁ<br />
ﺕﺎﻧﺍﻮﯿﺣﺭﺩ ﺕﺎﻧوﺭﺪﯿﺗﺍ یﻻﺎﺑ<br />
ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿﺑ ﻪﮐ ﻝﺎﻤﺘﺣﺍ ﻦﯾﺍ ﯽﻟو ،ﺩﻮﺷﯽﻣ<br />
ﺖﯾﺮﺗﺭﺁ<br />
و ﻞﯾﺪـﻌﺗ ﻥﺎﺴـﻧﺍ ﺭﺩ ﺍﺭ ﯽﻨﻤﯾﺍ ﻢﺘﺴﯿﺳ ﺩﺮﮑﻠﻤﻋ ﺖﺳﺍ ﻦﮑﻤﻣ<br />
ﻪﻌﻟﺎﻄﻣ . ﺖﺳﺍ ﻪﺘﻓﺮﮔ ﺭﺍﺮﻗ ﯽﺳﺭﺮﺑ ﺩﺭﻮﻣ ﺮﺘﻤﮐ ،ﺪﯾﺎﻤﻧ<br />
ﻢﯿﻈﻨﺗ<br />
ﻂـﺳﻮﺗ ﻪـﮐ ﺪـﯿﺋﻮﺗﺎﻣوﺭ ﺖـﯾﺮﺗﺭﺁ ﺎـﺑ ﻪﺑ ﻼﺘﺒﻣ<br />
ﺭﺎﻤﯿﺑ 5 یوﺭ<br />
ﺪـﻧﺍﻩﺪـﺷ<br />
ﻥﺎـﻣﺭﺩ ( 1200 mg/day)<br />
ﯽﮐﺍﺭﻮﺧ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺏﺬـﺟﺯﺎﺑ ﺮـﺑ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﺎـﻬﻨﺗ ﻪـﻧ ﻪـﮐ ﺪـﻫﺩﯽـﻣ<br />
ﻥﺎﺸـﻧ<br />
ﺎـﺑ ﻪﺴـﯾﺎﻘﻣ ﺭﺩ ﻪـﮑﻠﺑ ،ﻩﺩﻮـﺑ ﺮﺛﻮـﻣ ﻥﺍﺭﺎﻤﯿﺑ ﻦﯾﺍ ﺭﺩ ﻥﺍﻮﺨﺘﺳﺍ<br />
ﻢـﻫ ﯽﻨﯿﻟﺎـﺑ ﻢـﺋﻼﻋ ﺮﯿﮕﻤﺸـﭼ یﺩﻮـﺒﻬﺑ ﺚﻋﺎﺑ ﻝﺮﺘﻨﮐ ﻩوﺮﮔ<br />
ﯽﻫﺎﮕﺸـﯾﺎﻣﺯﺁ یﺎـﻫﺮﺘﻣﺍﺭﺎﭘ<br />
ﺶﻫﺎﮐ ﺎﺑ ﺪﻧوﺭ ﻦﯾﺍ . ﺖﺳﺍ ﻩﺪﺷ<br />
. ( 29)<br />
ﺖـﺳﺍ ﻩﺩﻮـﺑ ﻩﺍﺮﻤﻫ ( CRP و ESR)<br />
ﺏﺎﻬﺘﻟﺍ ﻪﺑ ﻁﻮﺑﺮﻣ<br />
ﯽــﻨﯿﻨﺟ یﺎــﻫﻝﻮﻠــﺳ<br />
ﺖﺸــﮐ ﺭﺩ ﺕﺎﻧوﺭﺪــﯿﻣﺎﭘ ﻞــﯿﺘﻣ یﺩ<br />
ﻩﺪﺷ<br />
IL-6 یﺯﺎﺳﺩﺍﺯﺁ ﺭﺩ ﯽﺒﺴﻧ ﺶﻫﺎﮐ ﺐﺟﻮﻣ ،ﻥﺍﻮﺨﺘﺳﺍ<br />
ﻥﺁ ﺮـﺛﺍ PTH ﻥﺩوﺰـﻓﺍ ﺎـﺑ ﯽﻬﺟﻮـﺗ ﻞـﺑﺎﻗ ﺭﻮـﻃ ﻪـﺑ<br />
ﻪـﮐ ﺩﻮﺑ<br />
ﺎـﯾ و ﺎـﻬﻨﺗ ﺕﺎـﻧوﺭﺩﻮﻠﮐ ﻞـﺑﺎﻘﻣ ﺭﺩ . ( 30)<br />
ﺩﻮـﺑ ﻪـﺘﻓﺎﯾ ﺶﯾﺍﺰﻓﺍ<br />
www.<strong>SID</strong>.ir<br />
82
ﻥﺍﺭﺎﮑﻤﻫ و یﺭﺎﯿﺷ ﺎﺿﺭ<br />
ﺖﺳﺍ ﻪﺘﻓﺮﮕﻧ ﺭﺍﺮﻗ ﯽﺳﺭﺮﺑ ﺩﺭﻮﻣ ﻩﺪﻧﺯ ﺩﻮﺟﻮﻣ ﺭﺩ ،ﺪﯾﺎﻤﻧﯽﻣ<br />
ﺮﯿﺴـﻣ ﺯﺍ یﺮﯿﮔﻮـﻠﺟ ﻝﺎـﺒﻧﺩ ﻪـﺑ<br />
ﻪـﮐ ﯽﻤﺴـﯿﻧﺎﮑﻣ ﻦﯿﻨﭽﻤﻫ و<br />
. ( 37)<br />
ﺖﺴﯿﻧ ﺭﺎﮑﺷﺁ ﺯﻮﻨﻫ ،ﺪﻫﺩﯽﻣ<br />
ﺥﺭ ﺕﺎﻧﻮﻟﺍﻮﻣ<br />
ﺭﺎـــﻤﯿﺑ 27 یﺍﻪـــﻌﻟﺎﻄﻣ<br />
ﺭﺩ ﻥﺍﺭﺎـــﮑﻤﻫ و Maccagne<br />
ﺎــﺑ ﻥﺎــﻣﺭﺩ ﺖــﺤﺗ ﻝﺎﺴــﮑﯾ ﺕﺪــﻣ ﻪــﺑ ﺍﺭ ﯽﻤﺴــﯿﺗﺎﻣوﺭ<br />
ﺭﺍﺮـﻗ ﻮﺒﺳﻼﭘ ﺎﯾ ( ﻪﻧﺍﺯوﺭ 1000 mg)<br />
ﯽﮐﺍﺭﻮﺧ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺩﻮـﺟو ﻢﻏﺮـﯿﻠﻋ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﺎـﺑ ﻥﺎـﻣﺭﺩ یﺍﺪﺘﺑﺍ ﺭﺩ . ﺪﻧﺩﺍﺩ<br />
یﺎــﻫﺮﺘﻣﺍﺭﺎﭘ ﯽــﺧﺮﺑ ﺭﺩ ﯽﺼــﺨﺸﻣ ﺩﻮــﺒﻬﺑ ،ﺩﺎــﺣ<br />
یﺭﺎــﻤﯿﺑ<br />
( ﯽﻫﺎﮕﺤﺒـﺻ ﯽﮕﺘﺴـﺧ)<br />
ﯽﮑﯿﻨﯿﻠﮐ و (ESR) ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ<br />
ﺶﯾﺎـﺳ ﺖﻓﺮﺸـﯿﭘ ﺪﻫﺎـﺷ ﻩوﺮـﮔ ﺭﺩ ﻦﯿـﻨﭽﻤﻫ . ﺪﺷ ﻩﺪﻫﺎﺸﻣ<br />
ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ ﺎﺑ ﻥﺎﻣﺭﺩ ﺖﺤﺗ ﻩوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ ﻞﺼﻔﻣ ﻑﺍﺮﻃﺍ<br />
ﺎـﺑ یﺪـﯾﺭو<br />
83<br />
ﻥﺎﻣﺭﺩ یﺮﮕﯾﺩ<br />
ﻪﻌﻟﺎﻄﻣ ﺭﺩ . ( 38)<br />
ﺩﻮﺑ ﺮﺘﺸﯿﺑ ﺭﺎﯿﺴﺑ<br />
ﻡوﺎـﻘﻣ ﻥﺍﺯﻮـﯿﻠﮑﻧﺍ ﺖﯿﻠﯾﺪﻧﻮﭙﺳﺍ ﺎﺑ ﯽﻧﺍﺭﺎﻤﯿﺑ ﺭﺩ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺭﺍﺮـﻗ ﯽﺑﺎـﯾﺯﺭﺍ ﺩﺭﻮﻣ یﺪﯿﯾوﺮﺘﺳﺍ ﺮﯿﻏ ﯽﺑﺎﻬﺘﻟﺍ ﺪﺿ ﻥﺎﻣﺭﺩ ﻪﺑ<br />
ﺍﺭ CRP و ESR ﺭﺩ یﺯﺭﺎﺑ ﺶﻫﺎﮐ ﻪﯿﻟوﺍ یﺎﻫﻪﺘﻓﺎﯾ<br />
. ﺖﻓﺮﮔ<br />
. ﺖـﺷﺍﺩ ﻪـﻣﺍﺩﺍ<br />
ﺰـﯿﻧ ﻪـﻫﺎﻣ6<br />
ﻥﺎـﻣﺭﺩ ﯽﭘ ﺭﺩ ﻪﮐ ﺩﺍﺩ<br />
ﯽﻣ ﻥﺎﺸﻧ<br />
،ﯽـﮑﯿﻨﯿﻠﮐ یﺎـﻫﺮﺘﻣﺍﺭﺎﭘ ﺭﺩ ﯽﻬﺟﻮـﺗ ﻞـﺑﺎﻗ ﺩﻮـﺒﻬﺑ ﻦﯿﻨﭽﻤﻫ<br />
ﯽﻧﺍﺭﺎﻤﯿﺑ ﺭﺩ یﺭﺎﻤﯿﺑ ﺖﯿﻟﺎﻌﻓ ﯽﮑﯾژﻮﻟﻮﯾﺩﺍﺭ<br />
و ﯽﻫﺎﮕﺸﯾﺎﻣﺯﺁ<br />
5 ﺕﺭﻮـﺻ ﻪـﺑ<br />
ﺍﺭ یﺪـﯾﺭو ﻞـﺧﺍﺩ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﺲﻟﺎـﭘ ﻪـﮐ<br />
. ( 39)<br />
ﺪﺷ ﻩﺪﻫﺎﺸﻣ ،ﺪﻧﺩﺮﮐﯽﻣ<br />
ﺖﻓﺎﯾﺭﺩ ﻩﺎﻣ 2ﻝﻮﻃﺭﺩ<br />
ﻖﯾﺭﺰﺗ<br />
: ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﯽﺒﻧﺎﺟ ﺽﺭﺍﻮﻋ<br />
ﺯﺍ ﯽﻟﺎﺧ ﺎﻫوﺭﺍﺩ ﺮﯾﺎﺳ ﺪﻨﻧﺎﻤﻫ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻑﺮﺼﻣ<br />
یﺭوﺮﺿ یﺮﻣﺍ ،ﺽﺭﺍﻮﻋ ﻦﯾﺍ ﻞﻣﺎﮐ ﺖﺧﺎﻨﺷ و ﺖﺴﯿﻧ<br />
ﻪـﺿﺭﺎﻋ ﻦﯾﺮـﺗﻊﯾﺎـﺷ<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ<br />
، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
ﻪﺿﺭﺎﻋ<br />
. ﺪـﺳﺭﯽـﻣ<br />
ﺮﻈﻧ ﻪﺑ ﺏﺎﻨﺘﺟﺍ ﻞﺑﺎﻗ ﺮﯿﻏ و<br />
و ﯽﻧﺍﻮﺨﺘـﺳﺍ ،ﯽﻧﻼﻀـﻋ ﺪﯾﺪﺷ یﺎﻫﺩﺭﺩ ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ<br />
ﺪـﻨﭼ ﺎـﺗ ﺕﺎﻗوﺍ ﯽﻫﺎﮔ<br />
ﻪﮐ ﺪﺷﺎﺑﯽﻣ<br />
ﺯوﺭ ﺪﻨﭼ یﺍﺮﺑ ﯽﻠﺼﻔﻣ<br />
ﺯﺍ ﺰـﯿﻧ ﻥﺍﺭﺎـﻤﯿﺑ ﺯﺍ یﺩﺍﺪـﻌﺗ<br />
،ﻩوﻼﻋ ﻪﺑ<br />
. ﺪﺑﺎﯾﯽﻣ<br />
ﻪﻣﺍﺩﺍ ﺰﯿﻧ ﻩﺎﻣ<br />
( Flu-Like symptoms)<br />
ﯽﮔﺩﺭﻮﺧﺎﻣﺮـﺳ ﻪﯿﺒـﺷ ﯽـﻤﯾﻼﻋ<br />
َﻻﻮـﻤﻌﻣ و ﻩﺩﻮﺒﻧ یﺪﺟ ﯽﻠﯿﺧ ﺽﺭﺍﻮﻋ ﻦﯾﺍ . ﺪﻧﺭﺍﺩ<br />
ﺖﯾﺎﮑﺷ<br />
ﺎـﺑ ﺎـﯾ و ﺪﻨﺑﺎﯾﯽﻣ<br />
ﺩﻮﺒﻬﺑ ﺯوﺭ ﺪﻨﭼ ﺽﺮﻋ ﺭﺩ ﺩﻮﺧ ﻪﺑ<br />
ﺩﻮﺧ ﺎﯾ<br />
. ( 40)<br />
ﺪﻨﺘﺴـﻫ ﻝﺮـﺘﻨﮐ ﻞـﺑﺎﻗ ﯽـﺘﺣﺍﺭ ﻪـﺑ ﻦﻓﻮﻨﯿﻣﺎﺘﺳﺍ ﻑﺮﺼﻣ<br />
ﺲﯿــﺑ ﯽــﻘﯾﺭﺰﺗ ﻑﺮﺼــﻣ ﺐــﻗﺎﻌﺘﻣ ( Uveitis)<br />
ﺖــﯾﺅﻮﯾ<br />
ﻩﺪـﺷ ﺵﺭﺍﺰـﮔ ﺩﺭﻮـﻣ ﺭﺎـﻬﭼ ﺭﺩ ﻂـﻘﻓ ﻥﻮﻨﮐﺎﺗ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
یﺭوﺮــﻣ<br />
ﺯوﺭ 6 ﺕﺪـﻣ ﻪـﺑ و یﺪـﯾﺭو ﺭﻮﻃ ﻪﺑ ﻪﻧﺍﺯوﺭ ﺍﺭ ﺕﺎﻧوﺭﺩﻮﻠﮐ<br />
TNF-α و IL-1<br />
ﻪـﻈﺣﻼﻣ ﻞـﺑﺎﻗ ﺶﻫﺎـﮐ . ﺪﻧﺩﻮﻤﻧ ﺖﻓﺎﯾﺭﺩ<br />
ﯽﻗﺎـﺑ ﺖـﺑﺎﺛ ﺯوﺭ 6 ﺯﺍ ﺲـﭘ و ﺪـﺷ ﻩﺪﻫﺎﺸﻣ ﺯوﺭ ﻪﺳ ﺯﺍ ﺲﭘ<br />
ﺭﺩ ﺎـﻬﻧﺁ یﺭﺎـﻤﯿﺑ ﻪـﮐ ﺭﺎـﻤﯿﺑ 32 ﻡوﺩ ﻪـﻌﻟﺎﻄﻣ ﺭﺩ . ( 34)<br />
ﺪﻧﺎﻣ<br />
ﺎﺑ ﻥﺎﻣﺭﺩ ﺖﺤﺗ ﺯوﺭ 90 ﺕﺪﻣ ﻪﺑ<br />
،ﺖﺷﺍﺩ<br />
ﺭﺍﺮﻗ ﻪﯿﻟوﺍ ﻞﺣﺍﺮﻣ<br />
ﺪـﻨﺘﻓﺮﮔ ﺭﺍﺮـﻗ ﻮﺒـﺳﻼﭘ<br />
ﺎﯾ ﺯوﺭ ﺭﺩ ﺕﺎﻧوﺭﺪﻨﻟﺁ ﻡﺮﮔﯽﻠﯿﻣ<br />
TNFa و IL-6 ، IL-1 ﺡﻮﻄﺳ ﺭﺩ یﺮﯿﮕﻤﺸﭼ ﺶﻫﺎﮐ ﻪﮐ<br />
ﺖـﺑﺎﺛ ﻪـﻌﻟﺎﻄﻣ 90 ﺯوﺭ ﺎـﺗ ﻪﮐ ﺪﺷ ﻩﺪﻫﺎﺸﻣ ﺯوﺭ 30 ﺯﺍ ﺲﭘ<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻪﻠﺠﻣ<br />
40<br />
ﻝﺮـﺘﻨﮐ ﻩوﺮـﮔ ﺭﺩ یﺭﺍﺩﯽـﻨﻌﻣ<br />
ﺮـﯿﯿﻐﺗ ﭻﯿـﻫ ﯽـﻟو ﺪﻧﺎﻣ ﯽﻗﺎﺑ<br />
ESR ﺢﻄـﺳ ﺭﺩ یﺭﺍﺩﯽﻨﻌﻣ<br />
ﺶﻫﺎﮐ ﻦﯿﻨﭽﻤﻫ . ﺪﺸﻧ ﻩﺪﻫﺎﺸﻣ<br />
ﺕﺎﻧوﺭﺪﻨﻟﺁ ﻪﮐ ﺩﺍﺩ ﻥﺎﺸﻧ ﻪﻌﻟﺎﻄﻣ ﻦﯾﺍ . ﺪﺷ ﻩﺪﻫﺎﺸﻣ<br />
CRP و<br />
ﻪــﯿﻟوﺍ ﻞــﺣﺍﺮﻣ ﺭﺩ ﯽﻧﺍﻮﺨﺘــﺳﺍ ﺪــﯾﺪﺠﺗ ﺶﻫﺎــﮐ<br />
ﺐــﺟﻮﻣ<br />
ﯽـﺒﯾﺮﺨﺗ ﺪـﺿ ﺕﺍﺮـﺛﺍ ﻻﺎـﻤﺘﺣﺍ و ﻩﺪﺷ ﺪﯿﺋﻮﺗﺎﻣوﺭ ﺖﯾﺮﺗﺭﺁ<br />
ﺢﻄﺳ ﺭﺩ ﺖﯿﺳﻮﻔﻨﻟ<br />
یﺎﻫﻩوﺮﮔ<br />
یﺮﮕﯾﺩ<br />
ﻪﻌﻟﺎﻄﻣﺭﺩ<br />
. ( 35)<br />
ﺩﺭﺍﺩ<br />
ﻪﺑ)<br />
یﺪﯾﺭو ﻞﺧﺍﺩ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ ﻪﮐ ﯽﻧﺍﺭﺎﻤﯿﺑ ﻥﻮﺧ ﯽﺟﺭﺎﺧ<br />
ﺭﺍﺮـﻗ ﯽـﺳﺭﺮﺑ ﺩﺭﻮـﻣ ،ﺪـﻧﺩﺮﮐ ﯽـﻣ ﺖـﻓﺎﯾﺭﺩ ( ﺯوﺭ 3 ﺕﺪﻣ<br />
+<br />
CD4 یﺎـﻫﺖﯿﺳﻮﻔﻨﻟ<br />
ﻩوﺮﮔ ﺮﯾﺯ ﺭﺩ ﻩﺪﻤﻋ ﺶﻫﺎﮐ . ﺖﻓﺮﮔ<br />
ﻪـﺑ<br />
،ﺪـﻧﺩﻮﺑ<br />
ﻩﺩﺮـﮐ ﺖـﻓﺎﯾﺭﺩ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﻪـﮐ ﯽﻧﺍﺭﺎﻤﯿﺑ<br />
ﺭﺩ<br />
ﺩﺍﺪـﻌﺗ ﺎـﯾ ﺪـﺻﺭﺩ ﺭﺩ یﺮـﯿﯿﻐﺗ ﭻﯿﻫ و ﺩﻮﺑ ﺪﺻﺭﺩ 50 ﻥﺍﺰﯿﻣ<br />
Natural killer یﺎـﻫﻝﻮﻠـﺳ<br />
ﺎـﯾ B یﺎـﻫﺖﯿـﺳﻮﻔﻨﻟ<br />
ﺺﻟﺎﺧ<br />
ﺪـﻫﺩﯽـﻣ<br />
ﻥﺎﺸـﻧ ﺩوﺪـﺤﻣ ﺕﺎﻌﻟﺎﻄﻣ ﻦﯾﺍ . ( 36)<br />
ﺖﺷﺍﺪﻧ ﺩﻮﺟو<br />
ﺭﺩ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ًﺎﺻﻮﺼـﺨﻣ و ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ ﻪﮐ<br />
ﻦﯿﮐﻮﺘﯿـﺳ ﺵوﺍﺮﺗ ﺐﺟﻮﻣ ﻥﺪﺑ ﺭﺩ ﻩﺩﺎﻔﺘﺳﺍ ﻝوﺍ<br />
ﺖﻋﺎﺳ 24<br />
. ﺩﻮﺷﯽﻣ<br />
IL-6 و TNF-α ،ﯽﺑﺎﻬﺘﻟﺍ<br />
ﺶﯿﭘ<br />
ﺲﯿﺑﻮـﻨﯿﻣﺁ ﻥﺁ ﻖـﯾﺮﻃ ﺯﺍ ﻪﮐ ﯽﻟﻮﮑﻟﻮﻣ<br />
ﻢﺴﯿﻧﺎﮑﻣ ًﺍﺮﯿﺧﺍ<br />
ﻩﺪﺷ ﻦﺷوﺭ ،ﺪﻧﻮﺷﯽﻣ<br />
ﻥﺍﻮﺨﺘﺳﺍ ﺏﺬﺟﺯﺎﺑ ﻊﻧﺎﻣ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺭﺩ ﺲﯾﺯﻮــﺘﭘﻮﭘﺁ ﺐــﺟﻮﻣ ﺎــﻫﺕﺎﻧﻮﻔﺴــﻓ<br />
ﺲﯿــﺑ ﻮــﻨﯿﻣﺁ . ﺖــﺳﺍ<br />
ﺎـﻫﺖـﺳﻼﮐﻮﺌﺘﺳﺍ<br />
ﺰـﯿﻧ و ﻝﺍﺭﻮـﻣﻮﺗ<br />
یﺎـﻫﻝﻮﻠـﺳ<br />
،ﺎـﻫژﺎﻓوﺮﮐﺎﻣ<br />
ﺲﯾﺯﻮـﺘﭘﻮﭘﺁ ﻪﺑ ﺖﯿﺳﺎﺴﺣ ﻥﺍﺰﯿﻣﺭﺩ<br />
ﯽﺳﺎﺳﺍ ﻉﻮﻨﺗ ﻪﭼﺮﮔﺍ . ﺪﻧﻮﺷﯽﻣ<br />
ﻖـﯾﺮﻃ ﺯﺍ ﯽﺑﺎـﻬﺘﻟﺍ ﺎـﻫﻦﯿﮐﻮﺘﯿـﺳ<br />
ﺯﺍ یﺭﺎﯿﺴﺑ ﻞﻤﻋ . ﺩﺭﺍﺩ ﺩﻮﺟو<br />
ﮏـــﯿﺗﻮﻧﻮﻣ ( Guanosine triphosphate)<br />
یﺎــﻫ GTP<br />
ﻡﺎـﺠﻧﺍ ( Reticular activating system)<br />
Ras ﮏـﭼﻮﮐ<br />
یﺎـﻫﻩﺩﺭ<br />
،ﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿﺑﻮـﻨﯿﻣﺁ ﻪﮐ ﯽﻤﺴﯿﻧﺎﮑﻣ . ﺩﺮﯾﺬﭘﯽﻣ<br />
ﻒـﻗﻮﺘﻣ ﻦﻣﺰـﻣ ﻩﺩﺎﻔﺘـﺳﺍ ﯽـﭘ ﺭﺩ ﺍﺭ ﯽﺑﺎـﻬﺘﻟﺍ<br />
یﺎـﻫﻦﯿﮐﻮﺘﯿﺳ<br />
www.<strong>SID</strong>.ir
. ﺩﻮﺷ<br />
یﺭﺍﺩﺩﻮﺧ ﻥﺎﻣﺰﻤﻫ ﺭﻮﻃ ﻪﺑ ( ﯽﮑﺷﺰﭘ ﻥﺍﺪﻧﺩ ﯽﺣﺍﺮﺟ<br />
ﺍﺭ یﺰـﯿﻠﻫﺩ ﻥﻮﯿﺳﻼﯾﺮﺒﯿﻓ ﻝﺎﻤﺘﺣﺍ ﺰﯿﻧ ﺕﺎﺷﺭﺍﺰﮔ ﯽﺧﺮﺑ<br />
ﻩﺩﻮـﻤﻧ ﺵﺭﺍﺰﮔ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ یﺪﯾﺭو ﻑﺮﺼﻣ ﺐﻗﺎﻌﺘﻣ<br />
ﻮﺘﯿﺘﺴـﻧﺍ ﻂـﺳﻮﺗ ﻪـﮐ ﯽﺗﺎـﻌﻟﺎﻄﻣ ﻦﯾﺮـﺧﺁ ﺭﺩ ﯽـﻟو ،ﺪـﻧﺩﻮﺑ<br />
ﻦﯿﻨﭼ<br />
،ﺖﻓﺮﮔ<br />
ﺕﺭﻮﺻ ﻩﺩﺮﺘﺴﮔ ﺭﻮﻃ ﻪﺑ ﺎﮑﯾﺮﻣﺍ ﯽﻠﻣ ﺖﻣﻼﺳ<br />
. ( 45)<br />
ﺪﺸﻧ<br />
ﻩﺪﻫﺎﺸﻣ ﯽﻃﺎﺒﺗﺭﺍ<br />
ﻦـﯾﺍ ﻥﺎﮔﺪﻨﺴـﯾﻮﻧﺮﯿﺧﺍ<br />
ﺵﺭﺍﺰـﮔ ﻩﺍﺮـﻤﻫ ﻪﺑ<br />
ﺎﻫﻩﺩﺍﺩ<br />
ﻦﯾﺍ<br />
ﯽﺑﺎﻬﺘﻟﺍ ﺪﺿ ﺶﻘﻧ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻪﮐ ﺪﻫﺩﯽﻣ<br />
ﻥﺎﺸﻧ<br />
ﮏـﺷﯽـﺑ<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ ، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
ﻪﻟﺎﻘﻣ<br />
. ﺪـﻧﺭﺍﺩ ﯽﻤﺴﯿﺗﺎﻣوﺭ ﻥﺍﺭﺎﻤﯿﺑ ﺭﺩ ﺍﺭ ﺯوﺩ ﻪﺑ ﻪﺘﺴﺑﺍو<br />
ﺐﻃ ﻢﻠﻋ ﺭﺩ ﺮﯾﺬﭘﺎﻧﺭﺎﮑﻧﺍ ﯽﻟﻮﺤﺗ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻑﺮﺼﻣ<br />
ﺕﺎـﺒﺛﺍ ﺩﺭﺍﻮـﻣ ﺭﺩ ﺎـﻫوﺭﺍﺩ ﻦﯾﺍ ﻑﺮﺼﻣ . ﺖﺳﺍ ﻩﺩﻮﻤﻧ ﺩﺎﺠﯾﺍ<br />
،ﻥﺍﺭﺎـﻤﯿﺑ ﯽﻨﯿﻟﺎـﺑ ﻂﯾﺍﺮـﺷ ﻦﺘﻓﺮـﮔ ﺮـﻈﻧ ﺭﺩ ﺎـﺑ ،ﯽﻧﺎﻣﺭﺩ ﻩﺪﺷ<br />
ﺽﺭﺍﻮـﻋ ﻞـﻣﺎﮐ ﺖﺧﺎﻨـﺷ و ﻑﺮﺼﻣ ﯽﮕﻧﻮﮕﭼ ﺯﺍ ﯽﻫﺎﮔﺁ<br />
ﻪـﻌﻣﺎﺟ ﺖﻣﻼـﺳ یﺎـﻘﺗﺭﺍ یﺎﺘـﺳﺍﺭ ﺭﺩ ﺎـﻬﻧﺁ ﺯﺍ ﯽﺷﺎﻧ ﯽﺒﻧﺎﺟ<br />
. ﺪﯾﺎﻤﻧﯽﻣ<br />
ﺎﻔﯾﺍ ﯽﯾﺍﺰﺴﺑ ﺶﻘﻧ<br />
References<br />
1. Bijvoet OL, Frijlink WB, Jie K, Van der Linden<br />
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ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﯽﺑﺎﻬﺘﻟﺍﺪﺿ ﺹﺍﻮﺧ<br />
ﺭﺩ ﺪﯿﯾوﺮﺘـﺳﺍ ﺕﺪﻣ ﻩﺎﺗﻮﮐ ﻑﺮﺼﻣ ﺎﺑ ﺩﺭﺍﻮﻣ ﻦﯾﺍ ﻡﺎﻤﺗ و ﺖﺳﺍ<br />
ﻼﺘﺒﻣ ﻥﺍﺭﺎﻤﯿﺑﺭﺩ ﺎﻣﺍ . ( 41-43)<br />
ﺖﺳﺍ<br />
ﻪﺘﻓﺎﯾ ﺩﻮﺒﻬﺑ ﺯوﺭ ﺪﻨﭼ ﺽﺮﻋ<br />
ﻑﺮﺼﻣ ﺕﺭوﺮﺿ ﺪﯾﺎﺑ ،ﯽﻤﺸﭼ ﺩﺎﺣ یﺎﻫیﺭﺎﻤﯿﺑ<br />
و ﺏﺎﻬﺘﻟﺍ ﻪﺑ<br />
ﯽﺑﺎﻬﺘﻟﺍ یﺎﻫیﺭﺎﻤﯿﺑ<br />
ﻪﻘﺑﺎﺳ ﺎﺑ یﺩﺍﺮﻓﺍﺭﺩ و ﺩﻮﺷ<br />
ﯽﺳﺭﺮﺑ ﺎﻬﻧﺁ<br />
( ﺖـﯾﺅﻮﯾ ﻪﻘﺑﺎـﺳ ﺎـﺑ ﻢﺴﯿﺗﺎﻣوﺭ ﻪﺑ یﻼﺘﺒﻣ ﻥﺎﮐﺩﻮﮐ ًﻼﺜﻣ)<br />
ﻢﺸﭼ<br />
. ﺪﻧﻮﺷ ﻩﺩﺎﻔﺘﺳﺍ ﻥﺍوﺍﺮﻓ ﺖﻗﺩ ﺎﺑ ﺪﯾﺎﺑ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ<br />
یّﺪـﺟ و ﻢـﻬﻣ ﺭﺎﯿﺴﺑ ﯽﻟو ﺭﺩﺎﻧ ﺽﺭﺍﻮﻋ ﺯﺍ ﺮﮕﯾﺩ ﯽﮑﯾ<br />
ﮏـﻓ ﺭﻻﻮﮑـﺳﺍوﺁ ﺯوﺮـﮑﻧ ،ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﻑﺮﺼـﻣ<br />
ﯽﻧﺎﻣﺰﻤﻫ ﺐﻗﺎﻌﺘﻣ ًﻻﻮﻤﻌﻣ ﻪﮐ ﺖﺳﺍ ( Osteonecrosis <strong>of</strong> Jaw)<br />
ﯽﮑـﺷﺰﭘﻥﺍﺪـﻧﺩ<br />
ﯽﺣﺍﺮﺟ یﺎﻫﻪﺳوﺮﭘ<br />
ﺎﺑ ﺎﻫوﺭﺍﺩ ﻦﯾﺍ ﻑﺮﺼﻣ<br />
ﻪﭽﻧﺎﻨﭼ ﻪﮐﺩﻮﺷﯽ<br />
ﻣ ﻪﯿﺻﻮﺗ ﻞﯿﻟﺩ ﻦﯿﻤﻫ ﻪﺑ . ( 44)<br />
ﺩﻮﺷﯽﻣ<br />
ﺩﺎﺠﯾﺍ<br />
ﺕﺎﻣﺍﺪﻗﺍ ﻪﺑ ﺯﺎﯿﻧ و ﺪﻨﮐﯽﻣ<br />
ﻩﺩﺎﻔﺘﺳﺍ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﺯﺍ یﺭﺎﻤﯿﺑ<br />
،ﺩﺭﺍﺩ ﯽﮑـﺷﺰﭘﻥﺍﺪـﻧﺩ<br />
ﯽﻤﯿﻣﺮﺗ ﺎﯾ و ﯽﻧﺎﻣﺭﺩ ﺹﺎﺧ ﯽﺣﺍﺮﺟ<br />
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یﺎـﻫﻪـﺳوﺮﭘ<br />
و ﺎـﻫوﺭﺍﺩ ﻦﯾﺍ ﻑﺮﺼﻣ)<br />
ﯽﻧﺎﻣﺭﺩ ﻡﺍﺪﻗﺍ وﺩ ﻦﯾﺍ<br />
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