Archive of SID
Archive of SID
Archive of SID
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. ﺪـﯾﺎﻤﻧﯽـﻣ<br />
ﺖـﻌﻧﺎﻤﻣ IL-6 یﺯﺎـﺳﺩﺍﺯﺁ ﺯﺍ PTH ﺎـﺑ ﻩﺍﺮـﻤﻫ<br />
ﺭﺩ ﺍﺭ IL-6 ﺪـﯿﻟﻮﺗ PTH ﻪﮐ ﺩﻮﺑ ﻩﺩﺍﺩ ﻥﺎﺸﻧ ﯽﻠﺒﻗ ﺕﺎﻌﻟﺎﻄﻣ<br />
ﮏﮑﺸـﮐ ﻥﺍﻮﺨﺘﺳﺍ ﻝﺎﻣوﺮﺘﺳﺍ یﺎﻫﻝﻮﻠﺳ<br />
و ﺎﻫﺖﺳﻼﺑﻮﺌﺘﺳﺍ<br />
ﺖـﺳﺍ ﻥﺁ ﺯﺍ ﯽﮐﺎـﺣ ﺕﺎﻋﻼﻃﺍ ﻦﯾﺍ . ( 31)<br />
ﺪﯾﺎﻤﻧﯽﻣ<br />
ﮏﯾﺮﺤﺗ<br />
،ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿـﺑ ﻥﺎـﻣﺭﺩ ﻪـﺑ ﺦـﺳﺎﭘ ﺭﺩ IL-6 ﻊـﺒﻨﻣ ﻪـﮐ<br />
ﻪـﮐ ﺩﻮـﺷﯽـﻣ<br />
ﺭﻮﺼـﺗ ﺭﻮـﻃﻦ<br />
ﯾﺍ ﻦﯾﺍﺮﺑﺎﻨﺑ . ﺪﺷﺎﺑﯽﻣ<br />
ﻥﺍﻮﺨﺘﺳﺍ<br />
ﻂـﺳﻮﺗ ﻪـﮐ ﺕﺎﻧﻮﻔﺴـﻓ ﺲﯿـﺑ ﻢـﮐ ﺮﯾﺩﺎـﻘﻣ ﺖـﺳﺍ ﻦـﮑﻤﻣ<br />
یﺯﺎــﺳﺩﺍﺯﺁ ﮏــﯾﺮﺤﺗ یﺍﺮــﺑ ،ﺩﻮــﺷﯽــﻣ<br />
ﺩﺍﺯﺁ ﻥﺍﻮﺨﺘــﺳﺍ<br />
. ﺪﺷﺎﺑ ﯽﻓﺎﮐ IL-6 ﯽﻌﺿﻮﻣ<br />
ﺯﺍ ﻩﺩﺎﻔﺘـﺳﺍ ﻪـﮐ ﻩﺩﺍﺩ ﻥﺎﺸـﻧ ﺮـﮕﯾﺩ ﯽﮑﯿﻨﯿﻠﮐ ﺕﺎﻌﻟﺎﻄﻣ<br />
ﻩﺍﺮﻤﻫ IL-6 و TNF-α یﺮﯿﮕﻤﺸﭼ ﺶﯾﺍﺰﻓﺍ ﺎﺑ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺎـﺑ ﻖﺑﺎـﻄﻣ<br />
. ﺖﺴـﯿﻧ ﻪـﻧﻮﮕﻨﯾﺍ IL-1 ﺩﺭﻮـﻣ ﺭﺩ ﯽـﻟو ،ﺖـﺳﺍ<br />
ﺵوﺍﺮـﺗ ﺐـﺟﻮﻣ ﺕﺎـﻧوﺭﺩﻮﻠﮐ ،ﯽﻫﺎﮕﺸـﯾﺎﻣﺯﺁ<br />
ﺕﺎـﻋﻼﻃﺍ<br />
ﺕﺎﻧوﺭﺪـﻧﺎﺒﯾﺭ ،ﺕﺍﺭﺎـﻈﺘﻧﺍ ﻑﻼﺧﺮﺑ ﺎﻣﺍ ﺩﻮﺷ ﯽﻤﻧ ﻦﯿﮐﻮﺘﯿﺳ<br />
ﺶﺠﻨﺳ ﺭﺩ ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ ﻥﺍﺰﯿﻣ ﻪﺑ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ و<br />
ﺯﺍ ﺮـــﺗ یﻮـــﻗ ﮏﯿﺘـــﺳﻼﮐﻮﺌﺘﺳﺍ ﯽﻧﺍﻮﺨﺘـــﺳﺍ<br />
ﺏﺬـــﺟﺯﺎﺑ<br />
ﻥﺎﺸـﻧ ﺕﺎـﻋﻼﻃﺍ ﻦـﯾﺍ ﻪـﭼﺮﮔﺍ . ( 32)<br />
ﺪﻨـﺷﺎﺑﯽﻣ<br />
ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﻪﮐ ﯽﻧﺍﺭﺎﻤﯿﺑ ﺭﺩ ﺎﻫﻦﯿﮐﻮﺘﯿﺳ<br />
ﻊﺒﻨﻣ ﻪﮐ ﺪﻫﺩﯽﻣ<br />
ﻦﮐﺎـﺳ یﺎﻫﻝﻮﻠﺳ<br />
ﺎﻬﻨﺗ ﻪﻧ<br />
،ﺪﻧﺍﻩﺩﺮﮐ<br />
ﺖﻓﺎﯾﺭﺩ یﺪﯾﺭو ﻞﺧﺍﺩ<br />
ﺭﺩ ﺩﻮـﺟﻮﻣ یﺎـﻫﻝﻮﻠـﺳ<br />
ًﻻﺎـﻤﺘﺣﺍ ﻪﮑﻠﺑ ﺖﺳﺍ ﻥﺍﻮﺨﺘﺳﺍ ﺭﺩ<br />
ﻦـﯾﺍ ﻦﯿـﻨﭽﻤﻫ . ﺪـﺷﺎﺑﯽـﻣ<br />
ﻦﯿﮐﻮﺘﯿـﺳ ﻊﺒﻨﻣ ﺰﯿﻧ ﻥﻮﺧ ﺵﺩﺮﮔ<br />
ﻦﯿــﺑ ﯽﻨــﺳ ﯽﯾﺎــﻧﺍﻮﺗ ﺭﺩ<br />
ﺕوﺎــﻔﺗ ﺩﻮــﺟو ﻝﺎــﻤﺘﺣﺍ ﻪــﻌﻟﺎﻄﻣ<br />
ﻦﯿﮐﻮﺘﯿـﺳ<br />
ﺵوﺍﺮـﺗ ﺐـﯿﻏﺮﺗ<br />
ﺖـﻬﺟ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ<br />
ﺎـﻬﻧﺁ ﺏﺬـﺟ ﺪـﺿ ﯽﯾﺎـﻧﺍﻮﺗ ﻑﻼﺧﺮـﺑ ﺍﺭ ﺏﺎـﻬﺘﻟﺍ<br />
<strong>Archive</strong> <strong>of</strong> <strong>SID</strong><br />
1388 ﺖﺸﻬﺒﯾﺩﺭﺍ و ﻦﯾﺩﺭوﺮﻓ ، 69 ﻩﺭﺎﻤﺷ ، ﻢﻫﺩﺯﻮﻧ ﻩﺭوﺩ<br />
ﺯﺍ ﻞـﺒﻗ<br />
ﻩﺩﺎﻔﺘـﺳﺍ ﺭﺩ ﻪـﻟﺎﻘﻣ ﻥﺎﮔﺪﻨﺴـﯾﻮﻧ ﺕﺎﻌﻟﺎﻄﻣ . ﺪﻫﺩﯽﻣ<br />
ﺶﯾﺍﺰﻓﺍ<br />
یﺎـﻫیﺭﺎـﻤﯿﺑ<br />
ﻪـﺑ ﻼﺘـﺒﻣ ﻥﺎـﮐﺩﻮﮐ ﺭﺩ ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿﺑﺯﺍ<br />
ﺖــﻬﺟ ﺭﺩ ﻢــﻫ ﺕﺎــﺒﯿﮐﺮﺗ ﻦـﯾﺍ ﺮﯿﺛﺎــﺗ ﺪــﯾﻮﻣ ﯽﻤﺴـﯿﺗﺎﻣوﺭ<br />
ﻢـﻫ و ﯽﻨﭘﻮﯿﺘـﺳﺍ ﺩﻮـﺒﻬﺑ ﺐـﻗﺎﻌﺘﻣ ﻥﺍﻮﺨﺘـﺳﺍ ﻢﮐﺍﺮﺗ ﺶﯾﺍﺰﻓﺍ<br />
( وﺭﺍﺩ ﯽﺑﺎـﻬﺘﻟﺍ ﺪﺿ ﺕﺍﺮﺛﺍ ﻞﯿﻟﺩ ﻪﺑ)<br />
یﺍﻪﻨﯿﻣﺯ<br />
یﺭﺎﻤﯿﺑ ﻝﺮﺘﻨﮐ<br />
. ( 33،5)<br />
ﺖﺳﺍ ﻩﺩﻮﺑ<br />
ﻦﯿﮐﻮﺘﯿـﺳ ﺡﻮﻄـﺳ ﯽﻨﯿﻟﺎـﺑ ﯽﯾﺎـﻣﺯﺁﺭﺎﮐ ﻪـﻌﻟﺎﻄﻣ وﺩ ﺭﺩ<br />
ﺪــﯿﺋﻮﺗﺎﻣوﺭ ﺎــﺑ ﻥﺍﺭﺎــﻤﯿﺑ ﺭﺩ ﺏﺎــﻬﺘﻟﺍ ﺯﺍ ﺪــﻌﺑ و ﻞــﺒﻗ ﻡﺮــﺳ<br />
ﯽﺑﺎـﯾﺯﺭﺍ ﺩﺭﻮـﻣ ﺕﺎﻧﻮﻔﺴـﻓ ﺲﯿـﺑ ﺎـﺑ ﻥﺎﻣﺭﺩ ﺖﺤﺗ ﺖﯾﺮﺗﺭﺁ<br />
ﻡﺮـﮔ ﯽـﻠﯿﻣ<br />
300 ﻥﺍﺭﺎـﻤﯿﺑ ﺖﺴﺨﻧ ﻪﻌﻟﺎﻄﻣ ﺭﺩ . ﺖﻓﺮﮔ ﺭﺍﺮﻗ<br />
ﺎﻫ ﺕﺎﻧﻮﻔﺴﻓ ﺲﯿﺑ ﯽﺑﺎﻬﺘﻟﺍﺪﺿ ﺹﺍﻮﺧ<br />
ﻩﺪـﺷ ﻩﺩﺍﺩ ﺖﺸـﮐ یﺎـﻫﻝﻮﻠـﺳ<br />
ﺭﺩ ﺍﺭ ﺩﺍﺯﺁ یﺎﻫوﺭﺍﺩ یﻻﺎﺑ<br />
ﯽﻣوﺯﻮـﭙﯿﻟ یﺎـﻫﻡﺮﻓ<br />
ﺰﯿﻧ ﺵﺭﺍﺰﮔ ﻦﯾﺪﻨﭼ ،ﺪﻨﻨﮐﯽﻣ<br />
ﯽﺳﺭﺮﺑ<br />
ﻪـﮐ ﺩﺍﺩ ﻥﺎﺸـﻧ ﺕﺎـﻌﻟﺎﻄﻣ ﻦـﯾﺍ . ﺪﻧﺩﺍﺩ ﺭﺍﺮﻗ ﯽﺑﺎﯾﺯﺭﺍ ﺩﺭﻮﻣ ﺍﺭ<br />
ﺲﯿــﺑ ﯽــﺧﺮﺑ ﺭﺩ ﻩﺪــﺷ ﻝﺎــﻌﻓ یﺎــﻫﺖﯿــﺳﻮﻧﻮﻣ<br />
ﺭﻮﻀــﺣ<br />
و IL-6 ،IL-1<br />
ﺪـﯿﻟﻮﺗ ،(<br />
ﺎـﻬﻧﺁ<br />
ﻪـﻤﻫ ﻪـﻧ ﻪـﺘﺒﻟﺍ)<br />
ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺖﺳﺍ<br />
ﻩﺪﺷ ﻥﺎﯿﺑ ﻪﻌﻟﺎﻄﻣ ﮏﯾ ﺭﺩ . ﺪﻨﻫﺩﯽﻣ<br />
ﺶﯾﺍﺰﻓﺍ ﺍﺭ<br />
ﻥﺍﺭﺪﻧﺯﺎﻣ ﯽﮑﺷﺰﭘ ﻡﻮﻠﻋ ﻩﺎﮕﺸﻧﺍﺩ ﻪﻠﺠﻣ<br />
TNF<br />
ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ ﻥﺎﻧ و ﻮﻨﯿﻣﺁ ﺕﺍﺮﺛﺍ ﺖﺳﺍ ﻦﮑﻤﻣ ﻪﮐ<br />
ﺕوﺎـﻔﺘﻣ ﻢـﻫ ﺎـﺑ ﯽﺑﺎـﻬﺘﻟﺍ<br />
ﺶﯿـﭘ یﺎﻫﻦﯿﮐﻮﺘﯿﺳ<br />
ﺢﺷﺮﺗ یوﺭ<br />
ﻪـــﻠﻤﺟ ﺯﺍ ،ﺎـــﻫﺕﺎﻧﻮﻔﺴـــﻓ<br />
ﺲﯿﺑﻮـــﻨﯿﻣﺁ ﻥﺎـــﻧ . ( 27)<br />
ﺪـــﺷﺎﺑ<br />
و ژﺎـﻓوﺮﮐﺎﻣ ﻪﺒـﺷ یﺎﻫﻝﻮﻠﺳ<br />
ﻂﺳﻮﺗ ﺪﻨﻧﺍﻮﺗﯽﻣ<br />
ﺕﺎﻧوﺭﺩﻮﻠﮐ<br />
ﻂـﺳﻮﺗ یﺍﻪـﯾﺰﺠﺗ<br />
ﺶﻨﮐﺍو ﺭﺩ ﺖﺳﻼﺑﻮﺌﺘﺳﺍ ﻪﺒﺷ یﺎﻫﻝﻮﻠﺳ<br />
ﻪـﮐ ATP ﻦﯿﻠﯿﺘﻣ<br />
یوﺎﺣ یﺎﻫگﻮﻟﺎﻧﺁ<br />
ﻪﺑ tRNA یﺎﻫﺰﺘﻨﺳ<br />
ﻦــﯾﺍ . ( 28)<br />
ﺪﻧﻮــﺷ ﻩﺰﯿﻟﻮﺑﺎــﺘﻣ ،ﻩﺩﻮــﺑ<br />
ﺰﯿﻟوﺭﺪــﯿﻫ ﻞــﺑﺎﻗ ﺮــﯿﻏ<br />
ﻪﺘـﺳﺩ وﺩ ﻪﺑ ﺍﺭ ﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑ ﻪﮐ ﻩﺪﺷ ﺐﺒﺳ ﺕﺍﺪﻫﺎﺸﻣ<br />
ﺲﯿﺑﻮـﻨﯿﻣﺁ ﻥﺎـﻧ و ﯽﺑﺎـﻬﺘﻟﺍ<br />
ﺶﯿـﭘ یﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
ﺲﯿﺑﻮﻨﯿﻣﺁ<br />
. ﺪﻨﯾﺎﻤﻧ<br />
ﻢﯿﺴﻘﺗﺰﯿﻧ<br />
ﺏﺎﻬﺘﻟﺍﺪﺿ یﺎﻫﺕﺎﻧﻮﻔﺴﻓ<br />
(<br />
In Vivo<br />
ﻂﯾﺍﺮﺷ)<br />
ﻩﺪﻧﺯ ﺩﻮﺟﻮﻣﺭﺩ ﺎﻫﺕﺎﻧﻮﻔﺴﻓﺲﯿﺑ<br />
ﺕﺍﺮﺛﺍ<br />
یﺎـﻫﺯوﺩ<br />
ﻪﮐ ﻩﺩﺍﺩ ﻥﺎﺸﻧ ﯽﺗﺎﻣﺪﻘﻣ یﺎﻫﯽﺳﺭﺮﺑ<br />
ﻪﭼﺮﮔﺍ<br />
ﺩﻮـﺒﻬﺑ ﺐﺒـﺳ ﯽﻫﺎﮕﺸـﯾﺎﻣﺯﺁ<br />
ﺕﺎﻧﺍﻮﯿﺣﺭﺩ ﺕﺎﻧوﺭﺪﯿﺗﺍ یﻻﺎﺑ<br />
ﺎـﻫﺕﺎﻧﻮﻔﺴـﻓ<br />
ﺲﯿﺑ ﻪﮐ ﻝﺎﻤﺘﺣﺍ ﻦﯾﺍ ﯽﻟو ،ﺩﻮﺷﯽﻣ<br />
ﺖﯾﺮﺗﺭﺁ<br />
و ﻞﯾﺪـﻌﺗ ﻥﺎﺴـﻧﺍ ﺭﺩ ﺍﺭ ﯽﻨﻤﯾﺍ ﻢﺘﺴﯿﺳ ﺩﺮﮑﻠﻤﻋ ﺖﺳﺍ ﻦﮑﻤﻣ<br />
ﻪﻌﻟﺎﻄﻣ . ﺖﺳﺍ ﻪﺘﻓﺮﮔ ﺭﺍﺮﻗ ﯽﺳﺭﺮﺑ ﺩﺭﻮﻣ ﺮﺘﻤﮐ ،ﺪﯾﺎﻤﻧ<br />
ﻢﯿﻈﻨﺗ<br />
ﻂـﺳﻮﺗ ﻪـﮐ ﺪـﯿﺋﻮﺗﺎﻣوﺭ ﺖـﯾﺮﺗﺭﺁ ﺎـﺑ ﻪﺑ ﻼﺘﺒﻣ<br />
ﺭﺎﻤﯿﺑ 5 یوﺭ<br />
ﺪـﻧﺍﻩﺪـﺷ<br />
ﻥﺎـﻣﺭﺩ ( 1200 mg/day)<br />
ﯽﮐﺍﺭﻮﺧ ﺕﺎﻧوﺭﺪﯿﻣﺎﭘ<br />
ﺏﺬـﺟﺯﺎﺑ ﺮـﺑ ﺕﺎﻧوﺭﺪـﯿﻣﺎﭘ ﺎـﻬﻨﺗ ﻪـﻧ ﻪـﮐ ﺪـﻫﺩﯽـﻣ<br />
ﻥﺎﺸـﻧ<br />
ﺎـﺑ ﻪﺴـﯾﺎﻘﻣ ﺭﺩ ﻪـﮑﻠﺑ ،ﻩﺩﻮـﺑ ﺮﺛﻮـﻣ ﻥﺍﺭﺎﻤﯿﺑ ﻦﯾﺍ ﺭﺩ ﻥﺍﻮﺨﺘﺳﺍ<br />
ﻢـﻫ ﯽﻨﯿﻟﺎـﺑ ﻢـﺋﻼﻋ ﺮﯿﮕﻤﺸـﭼ یﺩﻮـﺒﻬﺑ ﺚﻋﺎﺑ ﻝﺮﺘﻨﮐ ﻩوﺮﮔ<br />
ﯽﻫﺎﮕﺸـﯾﺎﻣﺯﺁ یﺎـﻫﺮﺘﻣﺍﺭﺎﭘ<br />
ﺶﻫﺎﮐ ﺎﺑ ﺪﻧوﺭ ﻦﯾﺍ . ﺖﺳﺍ ﻩﺪﺷ<br />
. ( 29)<br />
ﺖـﺳﺍ ﻩﺩﻮـﺑ ﻩﺍﺮﻤﻫ ( CRP و ESR)<br />
ﺏﺎﻬﺘﻟﺍ ﻪﺑ ﻁﻮﺑﺮﻣ<br />
ﯽــﻨﯿﻨﺟ یﺎــﻫﻝﻮﻠــﺳ<br />
ﺖﺸــﮐ ﺭﺩ ﺕﺎﻧوﺭﺪــﯿﻣﺎﭘ ﻞــﯿﺘﻣ یﺩ<br />
ﻩﺪﺷ<br />
IL-6 یﺯﺎﺳﺩﺍﺯﺁ ﺭﺩ ﯽﺒﺴﻧ ﺶﻫﺎﮐ ﺐﺟﻮﻣ ،ﻥﺍﻮﺨﺘﺳﺍ<br />
ﻥﺁ ﺮـﺛﺍ PTH ﻥﺩوﺰـﻓﺍ ﺎـﺑ ﯽﻬﺟﻮـﺗ ﻞـﺑﺎﻗ ﺭﻮـﻃ ﻪـﺑ<br />
ﻪـﮐ ﺩﻮﺑ<br />
ﺎـﯾ و ﺎـﻬﻨﺗ ﺕﺎـﻧوﺭﺩﻮﻠﮐ ﻞـﺑﺎﻘﻣ ﺭﺩ . ( 30)<br />
ﺩﻮـﺑ ﻪـﺘﻓﺎﯾ ﺶﯾﺍﺰﻓﺍ<br />
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