BocO NH HN NHOOHSNO n-Bu OO BocO N HN NHOOH OH BocO ...

BocO
N
H
HN
N
H
O
O
H
S
N
O
n-Bu
O
O
BocO
N
HN
N
H
O
O
H
OH
BocO
N
HN
N
H
O
O
H
S
N
O
n-Bu
O O
BocO
N
H
N
N
O
O
OH
H
H
BocO
N
H
HN
N
H
O
O
H
O
BocO
N
H
N
N
O
O
OH
H
H

O
N
H
HN
N
H
O
O
H
S
N
O
n-Bu
O
O
O
N
H
HN
N
H
O
O
H
S
N
O
n-Bu
O O
O
N
H
HN
N
H
O
O
H
O
O
N
H
HN
N
H
O
O
H
O
O
N
H
HN
N
H
O
O
H
O
O
N
H
HN
N
H
O
O
H
S
N
O
n-Bu
O
O
O
N
H
HN
N
H
O
O
H
O
O
N
H
HN
N
H
O
O
H
O
O
N
HN
N
H
O
O
H
OH
O
N
H
N
N
O
O
OH
H
H

H
I
Li/NH 3
e
H Ot-Bu
Br
O
Ot-Bu
O
Ot-Bu
O
Ot-Bu
O
Ot-Bu
H
I
O
O
Cr
O
O
OH
Cr
O
H
I
Bu 3 Sn
O
I
AIBN
Bu 3 SnH
t-BuO 2 C
t-BuO 2 C
t-BuO 2 C
O
O
H SnBu 3
O
H
N
t-BuO 2 C
t-BuO 2 C
t-BuO 2 C
O
TMS OTf
O TMS
Pd(OAc) 2
TMS
O
OAc
Pd
OAc
t-BuO 2 C
t-BuO 2 C
t-BuO 2 C
O Pd OAc
O
OAc
Pd
H
O
Cl
Bi Cl
HCl
t-BuO 2 C
t-BuO 2 C
t-BuO 2 C
O
Cl
Bi
Cl
Cl
Cl
Cl H O Bi Cl
HO Bi Cl
Cl
OH
O
O
H
Cl