Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Reference:
First author (year)
Kleineidam et al.,
1993
Area of
study
Philadelphia,
USA
Henk et al., 1993 UK Prospective
cohort study
Type of study Diagnosis of patients treated
with ionising radiation
Cohort study Primary posterior uveal
melanoma
Orbital lymphoma and
pseudotumour
Bessel et al., 1987 UK Cohort study Conjunctival or orbital non-
Hodgkin lymphoma
Packer et al., 2003
USA Cohort study Childhood brain tumours;
(cases and controls are
included in Whelan et al. 2010
– next line)
Number
irradiated
patients
Stem-cell transplantation (SCT) / Bone Marrow transplantation (BMT) in cancer treatment
Whelan et al., 2010 USA Cohort study Childhood cancer survivors
(all types of cancer)
Leung et al., 2007
Fahnehjelm et al.,
2007
Memphis,
USA
Gurney et al., 2006 USA
(multicentric)
Faraci et al., 2005
Prospective
cohort study
SCT in Leukaemia:and benign
diseases
Sweden Cohort study SCT in patients with several
diagnoses;
Cohort study SCT in leukaemia, neuroblastoma,
aplastic anaemia and
other diagnoses during
childhood
Italy Cohort study SCT in leukaemia, neuroblastoma,
non- Hodgkin
lymphoma
Control group definition Number nonirradiated
controls
– 112 –
Recruitment
period
Follow-up
period
n=365 - - 1976-1986 Until May
1992
n=40 - - 1979-1984 At least 8
years
n=112 Same diagnosis, but nonirradiated
n=3 1970-1984 70% of
patients at
least 1 year
n=1,607 Siblings n=3,418 1970-1986 Period not
stated, at
least 5
years
n=8,707
irradiated (out
of n=12,480
patients)
Siblings n=3,901 1970-1986 Period not
stated, at
least 5
years
n=123 Same diagnosis, but nonirradiated
n=17 s-TBI,
n=18 f-TBI
treated
n=176 with
TBI (and
n=59 chemotherapeutically
conditioned)
n=42 eligible,
n=41 ophthalmogically
evaluable
Same diagnosis, but nonirradiated
Siblings out of the
childhood cancer survivor
study, frequency-matched to
cases (3:1)
n=32 1990-2003 Median: 9
years, at
least 3
years
n=44
included 2004-
2006; treated
1986-2004
n=705 1974-1998
- - 1985-1993
7.0 years
(range 2-18
years) post
SCT
Median: 11
years
At least 10
years
Type of ionising radiation
applied in irradiated group
(as given in the paper)
Cobalt-60 plaque radiotherapy
Megavoltage irradiation with
Cobalt unit or 5 MeV linear
accelerator
Radiotherapy of the orbit with
cobalt beam therapy or with
superficial X-rays
Type of radiation therapy not
further specified
Several types of radiation
therapy
Total body irradiation (TBI)
TBI
TBI
TBI: until 1989 single source
of cobalt-60 unit, later 6 MV
single energy linear accelerator