Präsentation Prof. Klingberg
Präsentation Prof. Klingberg
Präsentation Prof. Klingberg
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Wirksamkeit<br />
TONES-study: Design<br />
Major inclusion criteria<br />
Primary Outcome<br />
Study condition<br />
(all patients receive<br />
standard care)<br />
Study treatment sessions<br />
(treatment duration 9 months)<br />
Hypothesis/Power Calculation<br />
N=198<br />
(to be included in<br />
3 study centres)<br />
<strong>Klingberg</strong> et al. 2011, Schiz. Bull.<br />
Schizophrenia patients (DSM IV/SCID),<br />
PANSS-modified negative syndrome ≥ 10,<br />
only moderate positive and depressive symptoms,<br />
no extrapyramidal side effects<br />
PANSS modified negative syndrome<br />
(PANSS-MNS, N1, N2, N3, N4, N6, G7, G16),<br />
assessed 12 months after inclusion<br />
CBT<br />
Cognitive Behavioural<br />
Therapy<br />
CR<br />
Cognitive Remediation<br />
20 20<br />
Expected effect size: d=0.41, required n=148,<br />
compensation for loss to follow up of 25%<br />
99 99<br />
<strong>Prof</strong>. Dr. <strong>Klingberg</strong><br />
16
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