Jahresbericht 2002/2003 - DRST

Instructions for reporting data to the DRST/EBMT Activity Survey 2003
( by A. Gratwohl and H. Baldomero with minor modifications)
• Table 1 (main table):
Enter the number of patients receiving their first transplant only, performed in 2003 and
not the number of transplants: One patient = one transplant. E.g.: If a patient has received
an auto-TX in 2002 and an allo-TX in 2003, no transplant should be entered in
Table 1, but an additional allo-TX should be entered in Table 2.
If a patient has received an auto-TX in 2003 followed by an allo-TX in 2003, enter the
auto-TX in Table 1 and the allo-TX as ´additional allo´ in Table 2.
o Non-id = any family member (matched or mismatched) other than HLAidentical
sibling or twin.
o Combined allogeneic BM + PBSC transplants should be entered as PBSC.
• Tables 1 and 4:
Cord blood transplants should be entered in table 1 individually as with other first
transplants, under the heading ‘PBSC’. In addition, enter the total number of cord blood
transplants (allogeneic and autologous separately) in table 4 under the heading ‘General
information'.
• Tables 1 and 4:
reduced intensity conditioning RIC (former mini-allo, non-myeloablative) transplants
should be entered in table 1 individually as with other first transplant patients. In addition,
enter the total number of RIC allos/autos performed in 2003 in table 4 under ‘General
information’. As there is no official definition of RIC transplants yet, we suggest the
following working proposal to be used, please try and stick to these definitions for the
survey 2003.
Only regimens with dosages below these listed should be classified as RIC.
• TBI based < 800 cGy TBI fractionated OR
< 400 cGy TBI single dose
AND (if additional chemotherapy is given)
< 60 mg/kg Cyclophosphamide
< 8 mg/kg Busulphan
< 100 mg/m² Thiotepa
< 80 mg/m² Melphalan
• Combination chemotherapy based < 8 mg/kg Bu and Cy < 100 mg/kg
< 80 mg/m² Melphalan
< 200 mg/m² Thiotepa
• Aplastic Anaemia < 100 mg/kg Cyclophosphamide
• Congenital Disease < 8 mg/kg Bu and Cy < 100 mg/kg
• ATG and Fludarabine in any RIC can be classified as RIC
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