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Pierre Chancel - Sanofi

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The ORIGIN Study could Potentially further Change the<br />

Landscape of Type 2 Diabetes Treatment<br />

Patients at high CV<br />

risk and IFG, IGT,<br />

newly detected or<br />

established diabetes<br />

(on 0 or 1 oral agent)<br />

R<br />

12,600 patients 40 countries Results in 2012<br />

Other agents for<br />

glycemic control<br />

Endpoints:<br />

CV morbidity/mortality<br />

All cause mortality<br />

Risk of diabetic microvascular<br />

outcomes<br />

Rate of progression of IFG or<br />

IGT to type 2 diabetes<br />

Can early use of Lantus ® reduce CV events in early/pre-diabetic<br />

patients more than standard glycemic care?<br />

8

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