Sebaceous Gland, Acne, Rosacea and Related Disorders Basic and ...

2nd Proceedings of the
International Conference
Sebaceous Gland, Acne, Rosacea
and Related Disorders
Basic and Clinical Research,
Clinical Entities and Treatment
Rome, Italy, September 13-16, 2008
Editors
CHRISTOS C. ZOUBOULIS
MAURO PICARDO
MEDIMOND
INTERNATIONAL PROCEEDINGS

© Copyright 2008
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FOREWORD
Seorrhoea, acne and rosacea are very common clinical disorders.
Together they comprise the group of skin disorders which requires more
treatment by dermatologists and other physicians than any other. Due
to this it is not surprising that the global interest in the physiology and
pathology of the sebaceous gland, the major skin organ involved, is
rapidly increasing. Current knowledge about the sebaceous gland suggests
that it is not merely the target of acne, but through its multiple
functions, represents “the brain of the skin”. Newly developed in vitro
models have facilitated this fascinating research; resulting in increasing
numbers of scientists and clinicians from different specialties getting
involved in sebaceous gland research. Including studies on: physiology,
pathology and pharmacology, of the sebaceous gland and the
pilosebaceous unit. Rapid developments in basic research and medicine
elsewhere have also influenced our field, this has resulted in numerous
reports appearing in many scientific journals and being announced
in specialty conferences all over the world.
This extensive expansion of knowledge makes it very difficult for
scientists to keep up-to-date with the latest progress in this research.
Considering that over a decade had past since the Workshop on the
Sebaceous Gland (Brussels 1995) and the 1st International Conference
on Sebaceous Gland, Acne, Rosacea and Related Disorders, (Berlin,
1997) another Conference was over due; in order to discuss the
numerous developments in this expanding field. Therefore it was a great
honour to arrange and invite interested parties to attend the 2nd International
Conference on Sebaceous Gland, Acne, Rosacea and Related
Disorders- “Basic and Clinical Research, Clinical Entities and Treatment”
which was held between the 13-16 September 2008 in Rome,
Italy at the IFO Congress Center “Raffaele Bastianelli”.

VI Foreword
The purpose of the conference was to construct a high impact scientific
programme, which provided information on the current research,
with clinical relevance to the disorders of the pilosebaceous unit. The
speakers were chosen for their contribution and impact on the discussed
areas. With the intention of not only attracting expects but also to motivate
young scientists and students, working, or wishing to work in
this fascinating area of study in the future.
The Conference was a great success and we felt very honoured to
host so many speakers with such major expertise during the event. The
selection of expertise was extensive and demonstrated again how this
fascinating area of research continues to attract great interest from
both established scientists and new ones to the field.
Now we present the proceedings of this meeting; where most of the
invited lectures and selected oral presentation are incuded. The index
follows the program of the meeting.
We hope that this proceeding, which clearly and shortly summarises
the main concepts of the presentation can be helpful to clinical dermatologists
providing a synthetic up date on the sebaceous gland, acne,
rosacea and related disorders.

INDEX
THE PILOSEBACEOUS UNIT: STRUCTURE, FUNCTION AND
CONTROL
Epidermal Surface Lipids
A. Pappas ..................................................................................................................... 1
Sebaceous Gland Lipids
M. Picardo ................................................................................................................... 5
Sebaceous Gland Receptors
C.C. Zouboulis ............................................................................................................ 9
Neuropeptides and Acne
R. Ganceviciene, M. Böhm, Graziene,
S. Fimme and C.C. Zouboulis .................................................................................... 17
Role of FGFR2-Signaling in the Pathogenesis of Acne
B. Melnik ..................................................................................................................... 23
Sebum Analysis of Individuals with and without Acne
A. Pappas, S. Johnsen, J.-C. Liu and M. Eisinger ................................................... 27
The Use of ZincamideÒ as Coadjuvant to Treatment with Adapalene in
Mild or Moderate Acne Reduces Erythema and Seborrhoea and Improves
Quality of Life
M. Pérez, M. Saban,
R. Pedragosa, M.J. Espadas,
A. Mirada and C. Trullás ........................................................................................... 31
Phospholipases Stimulate Lipogenesis in SZ95 Sebocytes
S. Schagen, A. Perchuc, R. Voegeli,
D. Imfeld, T. Schreier and C. Zouboulis ................................................................... 35
ENDOCRINOLOGY: FROM GENE TO THE PATIENT
Hormones and the Pilosebaceous Unit
W. Chen and C. Zouboulis ......................................................................................... 39

VIII Index
MICROBIOLOGY, IMMUNOLOGY AND INFLAMMATION
The Acne Biofilm
K. Honraet, B. Rossel, T. Coenye and H. Nelis ........................................................ 47
Propionibacterium Acnes Coordinately Augments Lipogenesis and
Matrix Metalloproteinase 2 Expression in Hamster Sebocytes
T. Sato, K. Iinuma, N. Akimoto, N. Noguchi,
M. Sasatsu and A. Ito ................................................................................................. 49
TNFα Gene Polymorphisms in the Pathogenesis of Acne Vulgaris
K. Szabó, G. Tax, D. Teodorescu-Brinzeu,
A. Koreck and L. Kemény ......................................................................................... 53
NUTRITION AND ENVIRONMENT
Nutrition in Acne
F. Danby ....................................................................................................................... 57
Tissue and Serum Inflammatory Cytokines Associated to Acne
in Relation to Cigarette Smoke
V. Bordignon, J.L. Sinagra, A. Vento, S. Bultrini,
P. Cordiali-Fei, B. Capitanio and F. Ensoli .............................................................. 67
ROSACEA: RESEARCH AND CLINICAL ASPECTS
Rhinophyma – Current Status
U. Wollina .................................................................................................................... 71
Possible Interaction Between Neuropeptides and UV Light in the Development
of Rosacea
S. Fimmel, E. Glass and C.C. Zouboulis ................................................................... 75
ACNEIFORM DERMATOSES: CLINICAL ASPECTS AND
TREATMENTS
The SAPHO Syndrome
I. Olivieri, V. Giasi, S. D’Angelo,
C. Palazzi and A. Padula ............................................................................................ 81
ACNE: CLINICAL ASPECTS AND TREATMENTS
Acne: Clinical Aspects
M. Herane.................................................................................................................... 85

Index
Modern Technology and Imaging for the Detection and Evaluation of
Acne
N. Kollias and G.O. Cula ............................................................................................ 91
Prepubertal Acne
A.W. Lucky .................................................................................................................. 99
Myths and Beliefs of Acne Pathogenesis
R. Wolf ......................................................................................................................... 105
Establishment of Acne Severity Grading in Japan
N. Hayashi, H. Akamatsu, M. Kawashima
and Japanese acne study group ................................................................................. 113
Zileuton, a New Efficient and Safe Systemic Anti-acne Drug
C.C. Zouboulis ............................................................................................................ 119
Advances in Measures of Clinical Acne Severity
J. Tan ............................................................................................................................ 129
PATIENT MANAGEMENT: PSYCHOLOGICAL ASPECTS AND
QUALITY OF LIFE
Measurement of Quality of Life
A.Y. Finlay ................................................................................................................... 135
PATIENT MANAGEMENT: PHYSICAL TREATMENTS
Variability in Absorption of Minocycline Clinical Implications
M. Wortzman and J. Leyden ..................................................................................... 143
Chemical Peeling for Acne in Japan
Y. Miyachi.................................................................................................................... 149
Azelaic Acid Counteracts the Inflammatory Response Elicited in Human
Keratinocytes
E. Camera, A. Mastrofrancesco, E. Izzo, N. Aspite,
M. Ottaviani and M. Picardo .................................................................................... 153
Auhtor Index ................................................................................................................ 159
IX