Diseases of the Lung and Respiratory Tract Part
Diseases of the Lung and Respiratory Tract Part
Diseases of the Lung and Respiratory Tract Part
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Pulmonary Hypertension<br />
• Emphysema<br />
– Hypoxia <strong>and</strong> alveolar destruction reduce <strong>the</strong> number <strong>of</strong><br />
capillaries, causing increased arterial resistance,<br />
• Congenital heart disease<br />
– Elevated pressures due to valvular disease<br />
• Recurrent PE<br />
– Reduced area <strong>of</strong> vascular bed with consistent pressures<br />
• VOD<br />
• Fenfluramine/phenterimine<br />
• Idiopathic<br />
– Decreased production <strong>of</strong> nitric oxide <strong>and</strong> prostacyclin <strong>and</strong><br />
increased levels <strong>of</strong> endo<strong>the</strong>lin, leading to endo<strong>the</strong>lial cell<br />
activation <strong>and</strong> thrombogenesis<br />
– Women 20-40
Change language