klini^ko ispituvawe na terapiskata efikasnost, podnoslivost i

Clinical trial on terapeutic efficacy, tolerability and safety of peroral solutions Varumin 1 and 2 (Interevrogeneks)
in a combined treatment with polyvitamin – antioxidative therapy in patients with biologicaly
(PCR) detected HPV infection of high-risk type, with or without biopticaly verified CIN I
Chart 1. Distribution of patients treated with placebo according to colposcopic findings on first,
second and third check up
20
18
16
14
12
10
8
6
4
2
0
12 13
2. PAP findings
17
14
12 13
University Gynecology and Obstetrics Clinic, Vodnjanska bb, University St. Cyrillus and Methodius, Skopje,
Macedonia
20
I II III
9
4
normal
suspicious
abnormal
Table 3. Distribution of patients treated with the investigated agent according to PAP findings on
first, second and third check up
PAP findings of the group
treated with investigated
agent
I II III
n % n % n %
normal findings ( 0 ) 20 43.5 22 53.66 28 75.7
Low-grade SIL ( 1 ) 19 41.3 14 34.15 7 18.9
ASC-H / ASC-US ( 2 ) 7 15.2 4 9.76 1 2.7
High grade SIL ( 3 ) 0 0 1 2.43 1 2.7
Cais suspicious ( 4 ) 0 0 0 0 0 0
total 46 100 41 100 37 100
Analysis with Friedman ANOVA test did not present statistical significant differences between
PAP findings on the first, the second and the third check-up among patients treated with the
investigated agent. (ANOVA Chi Sqr. = 5,096 df = 2 p = 0,0782)
Analysis with Friedman Wilcoxon Matched Pairs Test did not present statistical significant
differences between PAP findings on the first and the second check-up among patients
treated with the investigated agent. (T = 7,00 Z = 0,733 p = 0,4630 )
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