klini^ko ispituvawe na terapiskata efikasnost, podnoslivost i
klini^ko ispituvawe na terapiskata efikasnost, podnoslivost i
klini^ko ispituvawe na terapiskata efikasnost, podnoslivost i
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Clinical trial on terapeutic efficacy, tolerability and safety of peroral solutions Varumin 1 and 2 (Interevrogeneks)<br />
in a combined treatment with polyvitamin – antioxidative therapy in patients with biologicaly<br />
(PCR) detected HPV infection of high-risk type, with or without biopticaly verified CIN I<br />
A<strong>na</strong>lysis with Friedman Wilcoxon Matched Pairs Test did not present statistical significant<br />
differences between PAP findings on the first and the third check-up among patients treated<br />
with the investigated agent. (T = 15,00 Z = 1,274 p = 0,2026)<br />
A<strong>na</strong>lysis with Friedman Wilcoxon Matched Pairs Test did not present statistical significant<br />
differences between PAP findings on the second and third check-up among patients treated<br />
with the investigated agent. (T = 9,00 Z = 1,260 p = 0,2075 )<br />
Chart 3. Distribution of patients treated with the investigated agent according to PAP findings on<br />
first, second and third check up<br />
30<br />
25<br />
20<br />
15<br />
10<br />
5<br />
0<br />
20 19<br />
7<br />
0 0<br />
22<br />
14<br />
4 1 0<br />
University Gynecology and Obstetrics Clinic, Vodnjanska bb, University St. Cyrillus and Methodius, Skopje,<br />
Macedonia<br />
28<br />
I II III<br />
7<br />
1 1 0<br />
A<strong>na</strong>lysis with Friedman ANOVA test presented statistical significant differences between PAP<br />
findings on the first, the second and the third check-up among patients treated with placebo.<br />
(ANOVA Chi Sqr. = 8,00 df = 2 p = 0,01832)<br />
A<strong>na</strong>lysis with Friedman Wilcoxon Matched Pairs Test did not present statistical significant<br />
differences between PAP findings on the first and the second check-up among patients<br />
treated with placebo. (T = 5,00 Z = 0,000 p = 1,00)<br />
A<strong>na</strong>lysis with Friedman Wilcoxon Matched Pairs Test did not present statistical significant<br />
differences between PAP findings on the first and the third check-up among patients treated<br />
with placebo. (T = 2,00 Z = 1,782 p = 0,0747)<br />
A<strong>na</strong>lysis with Friedman Wilcoxon Matched Pairs Test presented statistical significant<br />
differences between PAP findings on the second and the third check-up among patients<br />
treated with placebo, thus presenting statistically significant deterioration among patients<br />
treated with placebo according to PAP findings between the second and the third check-up.<br />
(T = 0,00 Z = 2,201 p = 0,0277)<br />
0<br />
1<br />
2<br />
3<br />
4<br />
26
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