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Reversible Cerebral Vasoconstriction Syndromes (RCVS)

Reversible Cerebral Vasoconstriction Syndromes (RCVS)

Reversible Cerebral Vasoconstriction Syndromes (RCVS)

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<strong>RCVS</strong> versus PACNS<br />

• 1950s: Primary angiitis of the CNS (PACNS)<br />

uniformly poor outcome; requires prompt<br />

immunosuppressive therapy<br />

• Until late 2000s: <strong>RCVS</strong> under-recognized<br />

(variable nomenclature - Call’s, BACNS, PPA,<br />

vasospasm in eclampsia, TCH, migraine, drugs)<br />

• 1950s-2000s: patients with <strong>RCVS</strong> misinterpreted<br />

as having PACNS due to overlapping features<br />

such as headache, cerebral angiographic<br />

abnormalities, and ischemic stroke<br />

patients with <strong>RCVS</strong> exposed to the risks of brain<br />

biopsy, chronic immunosuppressive therapy

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