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Glial cells (stromal cells) Oligodendrocytes ... - CSU PVM 2014

Glial cells (stromal cells) Oligodendrocytes ... - CSU PVM 2014

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Neurons release glutamate into synaptic cleft<br />

Astrocytes reduce glutamate to glutamine and release back into synaptic<br />

cleft<br />

Taken back up by neuron and reused<br />

NADH is important in the conversion of glutamate to glutamine<br />

With disruption to the Na/K pump, enzyme activity reduced and ammonium<br />

accumulates in the astrocyte<br />

Glutamate accumulates, exerts its excitatory effect, <strong>cells</strong> run out of energy<br />

23

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