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260<br />

Company Portrait of<br />

UnaveraChemLab GmbH<br />

The management of the group of companies consisting<br />

of UnaveraChemLab GmbH <strong>and</strong> <strong>Aaron</strong> <strong>Chemistry</strong><br />

GmbH disposes of a long lasting tradition in science of<br />

chemistry.<br />

Already Dr. Bruno v. Zychlinski, father of the current CEO<br />

of UnaveraChemLab GmbH, worked during the nineteen-thirties<br />

in the fields of chemical research <strong>and</strong> developed<br />

on behalf of Wacker Chemie amongst others the<br />

patent-registered polyvinyl chloride (=PVC) in 1935.<br />

His company “Mittenwald Chemie”, founded in 1948,<br />

manufactured pastes <strong>for</strong> ball pens <strong>and</strong> dyestuff <strong>for</strong><br />

writing instruments <strong>and</strong> exp<strong>and</strong>ed dynamically to a<br />

worldwide leading company in that industry.<br />

In 1982, his son Dr. Hasso v. Zychlinski as a motivated<br />

chemist in synthesis took over the company Unavera-<br />

ChemLab GmbH, in brief Unavera GmbH, which is<br />

today also located in Mittenwald/Germany. Since that<br />

time, Unavera is active as an independent producer of<br />

organic fine chemicals.<br />

Beside the st<strong>and</strong>ard program, being a variety of product<br />

lines of chemical compounds, chemical synthesis as per<br />

customer’s specification under secrecy agreement is the<br />

most important line of business of the private company.<br />

Furthermore, Unavera GmbH is executing development<br />

orders <strong>for</strong> intermediates <strong>and</strong> drugs, which later on have<br />

to get converted into commercial scale. Another focus is<br />

the specialization in multistep reactions <strong>for</strong> complex<br />

molecules.<br />

Additionally, chiral syntheses are carried out by<br />

means of enzymatic reactions in close <strong>and</strong> strictly<br />

confidential cooperation with the specialist X-Zyme<br />

GmbH, Düsseldorf/Germany, (see page 264). Regular<br />

customers of Unavera GmbH are companies doing<br />

own research or being producers of pharmaceuticals<br />

<strong>and</strong> pesticides.<br />

The reactors of the company are designed <strong>and</strong> equipped<br />

<strong>for</strong> syntheses in volumes of kilograms up to multi tons<br />

as indicated in the product listing on page 12. In case<br />

of even larger quantities, such dem<strong>and</strong>s will be produced<br />

in close cooperation with partners having larger<br />

production capacity. Necessary <strong>and</strong> exclusively <strong>for</strong> specific<br />

customers developed procedures can be serially applied<br />

<strong>and</strong> are protected by contracts. This guarantees<br />

furthermore that the compounds will be reproduced in<br />

same purity <strong>and</strong> identity as be<strong>for</strong>e.<br />

For syntheses Unavera GmbH disposes of a cascade of<br />

enamel reactors being equipped as multi purpose plant<br />

as well as stainless steel <strong>and</strong> glass reactors <strong>for</strong> volumes<br />

of 20 up to 1000 liters. The temperature range covers<br />

+10 degree Celsius up to +180 degree Celsius,<br />

whereas the stainless steel reactors can be operated in a<br />

range of -40 degree Celsius up to +220 degree Celsius<br />

<strong>and</strong> with pressure down to 9 bar.<br />

Separation of solids is effected by vacuum nutsches, pressure<br />

filters or a hastelloy peeler centrifuge. Various dryer<br />

working under normal pressure or vacuum as well as<br />

refining <strong>and</strong> sieving machines are used <strong>for</strong> treatment of<br />

solids. All the plants <strong>and</strong> machines can optionally be<br />

rendered inert according to the specific requirement with<br />

nitrogen or argon. Electrical explosion prevention is<br />

applied. Environment protection<br />

has a very high priority:<br />

with general use of air<br />

purification, gas washer<br />

<strong>and</strong> strict waste water conditioning<br />

as well as consistent<br />

waste management<br />

with appropriate <strong>and</strong> controlled<br />

removal is taken care<br />

<strong>for</strong> a clean environment.<br />

Quality <strong>and</strong> customer satisfaction<br />

are the highest values<br />

of the management<br />

according to st<strong>and</strong>ard ISO<br />

9001:2000, controlled by<br />

official German inspection<br />

authority TÜV-Süd.<br />

Quality control is supervised<br />

by the independent analytical<br />

department, whereas<br />

the total workflow of receipt<br />

of goods, production <strong>and</strong> analysis is controlled by the<br />

head of analytical department.<br />

The laboratories are prepared <strong>for</strong> development <strong>and</strong> quality<br />

control in view to all the analytical procedures required<br />

like HPLC, GC, FTIR, HPLCMS <strong>and</strong> NMR. Melting<br />

point <strong>and</strong> moisture determination as well as potentiometric<br />

titration complete the range of control services.<br />

These are the fundamentals <strong>for</strong> the production of APIs<br />

according to cGMP guidelines.<br />

All the chemical compounds, assorted according to the<br />

product line index (see page 12), are listed in this<br />

catalogue on page 14 ff. <strong>and</strong> can be delivered within<br />

short notice subject to the requested quantity. Numerous<br />

further derivates <strong>and</strong> homologous compounds can be<br />

offered on specific inquiries.<br />

The relationship to our customers has been established<br />

on a personal <strong>and</strong> confidential basis over lots of years,<br />

<strong>and</strong> customer satisfaction has always been our highest<br />

objective <strong>and</strong> motivation simultaneously. We shall do our<br />

level best also in future to keep the reputation of Unavera<br />

GmbH in your cognition at least on the actual level <strong>and</strong><br />

will also save our well known high level of reliable <strong>and</strong><br />

flexible h<strong>and</strong>ling of your orders <strong>and</strong> requests. The long<br />

lasting family tradition of the group of companies in connection<br />

with <strong>Aaron</strong> <strong>Chemistry</strong> GmbH is a value to be<br />

conserved <strong>for</strong> the future.<br />

In this respect, we refer to the synergies between<br />

Unavera GmbH <strong>and</strong> <strong>Aaron</strong> <strong>Chemistry</strong> GmbH in the<br />

fields of development/know how transfer, production,<br />

analysis, purchasing <strong>and</strong> distribution, which will be even<br />

more intensified in future to your benefit.<br />

Already today these synergies mean <strong>for</strong> the customer that<br />

due to the large <strong>and</strong> flexible production capacities of<br />

Unavera GmbH in combination with the confidential <strong>and</strong><br />

close know how transfer with <strong>Aaron</strong> <strong>Chemistry</strong> GmbH<br />

as a specialist <strong>for</strong> development, all the chemical compounds<br />

can be delivered in homogeneous quality within<br />

short notice even up to larger dem<strong>and</strong>s. In order to avoid<br />

shortages in capacity, Unavera GmbH is currently exp<strong>and</strong>ing<br />

its laboratory facilities.<br />

The Unavera-Team wishes to thank you <strong>for</strong> having<br />

enjoyed your confidence in the past <strong>and</strong> is gladly<br />

looking <strong>for</strong>ward to the close <strong>and</strong> reliable cooperation<br />

with you in future.<br />

We should appreciate it very much to support you, as a<br />

traditional or new customer, on your way to success <strong>and</strong><br />

are motivated to show you in case of individual development<br />

orders <strong>and</strong> customized syntheses our efficiency.<br />

Dr. Hasso v. Zychlinski<br />

261

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