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262 Company Portrait of Aaron Chemistry GmbH Today’s Aaron Chemistry GmbH, being a producer of organic fine chemicals, was founded as a one-man-operation in January 2002 by Dr. Alexander v. Zychlinski. The company started running the first laboratory in January 2003 in Eching, a small town in Upper Bavaria, and is ever since producing chemical compounds. Like today, the first product range covered organic compounds which were synthesized in different ways. On the one hand, compounds as product lines like thiobenzamides, thiophenylacetamide as well as chiral and racemic alpha-amino alcohols are produced by classical methods of synthesis. On the other hand, imidazolium and imidazolidinium salts being catalysts for new and modern catalytic reactions are deliverable. These ionic liquids, belonging to the Aaron Chemistry GmbH-Product Portfolio, are basing upon imidazole and serve as substitutes for classical, organic solvents. A third range of production since company foundation is chemical synthesis on a customer-specific basis. These orders are very often placed by customers doing research on pharmaceuticals and agricultural pesticides. The possible ranges of quantities to be deliverable vary from gram to kilogram scale. The products offered in the catalogue are classified by product lines (see page 38) and can be delivered ex stocks at short notice. The current delivery program of Aaron Chemistry GmbH includes additionally also chemical compounds like piperazines, piperdines and other compounds being originally produced by former company EMKA GmbH. Even non-standard substances and products like monosubstituted piperazines, several 2, 4-dichlorinepyrimides and azides complete the actual delivery program of Aaron Chemistry GmbH. Since March 2008, Aaron Chemistry GmbH is located in Munich and therefore perfectly connected with international transportation infrastructure. The requirement of immediate deliveries even to distant places all over the world has become of more and more importance, especially in case of very small laboratory demands. In larger and well equipped production facilities, our highly qualified and over many years experienced research and production-team is now prepared to produce beside the more than 1000 compounds being listed in the catalogue (see page 44 ff.) all kinds of required derivates out of these. Further continuous information about new or modified compounds as a consequence of our research can be obtained next from our website www.aaron-chemistry.de, which is currently having a relaunch, but will be online again soon. The technical and analytical equipment consisting of gasphase chromatographs as well as testing procedures and measuring methods HPLC-MS, NMR and IR will guarantee our reliable and at any time reproducible quality standard for all the deliveries. Inspite of growing energy and labour costs as well as investments in production equipment to ensure the quality standard and the enlargement of the product range, we in general refrained from increasing our price level since 2003. Therefore, we are glad to note that we could hold most of the prices in catalogue steady, were even in a position to reduce some and only had to raise a few modestly. Due to its own business development, Aaron Chemistry GmbH is somewhat proud to mention the growing, own flexibility caused by a rate of export trade of more than 50 per cent with regard to the catalogue assortment. Especially on the European, North American as well as some Asian markets, Aaron-Products observe steadily rising sales. Our turnover with customer specified compounds, however, is primarily generated in Germany and Austria. Also in future we intend to meet the challenges of market globalization and to serve our appreciated traditional but also new international customers with the best product and service quality they deserve. At the same time, we shall allocate also in future adequate capacity for research and development for customerspecific synthesis. So far it has always been an exclusive advantage for our customers to have customer-specific synthesis composed at Aaron Chemistry GmbH. Based on our flexible company organization in combination with a lean cost structure, it has been for a long time an important element of our business model to offer customized synthesis services within short time at more competitive prices compared to others. Moreover, it is well known in the market that we have lots of chemical compounds ex stock in very small units available and can accordingly deliver at short notice. Furthermore, our delivery program includes numerous chemical compounds being worldwide exclusively available only with Aaron Chemistry GmbH. In order to assure our customers also in future with both companies of the group, Aaron Chemistry GmbH together with UnaveraChemLab GmbH, a successful cooperation as usual, we decided in the course of our strategic planning that both companies will even intensify their integration. Several synergies in purchase, research and development, production and quality control as well as in distribution will be even more enforced. Increasingly, our customers observe the advantage to cooperate with our group in view to the fact that the reproducibility of compounds having being synthesized at Aaron Chemistry GmbH in quantities for research and development demands can be guaranteed also for delivery quantities up to metric tons, produced at Unavera ChemLab, due to the well protected but very intensive know how transfer between both companies. This means that we can deliver without any time delay different quantities of chemical compounds from laboratory test up to series-production readiness in each quantity unit which our customers may require just in time. Our production facilities and equipments for quality management are of different capacities, completely equipped and will support you in view to the fact that you as our customer can count on constant quality standard in all the development and production stages. Owing to our presence at local and international conventions and fairs as well as our participation in the German independent working group for producers of customized synthesis compounds named CASID we shall be also in future well prepared to be your competent consultants in view to new products and product developments. We thank you very much for your awarded confidence in our company and our products and are honestly looking forward to our mutual and successful partnership in future. Dr. Alexander v. Zychlinski 263
264 265 Die Enzymtechnologie Die Transformation von nicht-natürlichen Verbindungen durch Enzyme, so genannte Biokatalysatoren, hat verschiedene Vorteile gegenüber dem chemischen Syntheseweg. Neben der hohen Stereo- und Regioselektivität weisen enzymatische Reaktionen auch eine hohe Enantioselektivität auf, die besonders für die Synthese chiraler Produkte von großer Bedeutung ist. So können Produkte mit einer hohen Enantiomerenreinheit gewonnen werden. Durch den Einsatz von Enzymen werden jedoch nicht nur Reaktionen beschleunigt, sondern auch viele erst ermöglicht. Dadurch können neue Prozessverfahren entwickelt, aber auch viele bestehende chemische Synthesewege vereinfacht und ersetzt werden. Wir sind davon überzeugt, dass die Kompetenz und das Wissen unseres Teams eine ideale Ergänzung Ihrer Laboratorien darstellt und Ihnen helfen wird, Ihr IP und Portfolio zu erweitern. Mit uns haben Sie einen zuverlässigen Partner für Ihr Unternehmen in den folgenden Bereichen: · Identifikation und Entwicklung relevanter enzymatischer Prozesse · Biokatalyse: Enzymatische Synthesen chiraler Produkte Kapazitäten: · Ein breites Angebot von über 250 Biokatalysatoren · Rekombinante R- und S-Oxidoreduktasen, Lipasen, Esterasen, Aminodehydrogenasen und Amidasen · Ganzzellbiotransformation, Escherichia coli, Saccharomyces cerevisiae, Candida Boidinii; Candida Parapsilosis, Hansenula Polymorpha · Verschiedene Enzym-Sammlungenen, welche basierend auf den Wildtyp-Sequenzen erstellt wurden · Fermenter, GC’s, HPLC’s, UV-VIS-Spektrometer, IR-Spektrometer · Molekularbiologische Labore, S1-Labore, Labore für die Aufreinigung und Analytik, Labore für die Kultivierung · Reaktoren 100 – 1000 Liter · Falls notwendig, Produktion unter Bedingungen der cGMP In case of interest in these compounds being developed with enzyme technology we are glad to offer you according to your detailed inquiry. Enzyme Technology von Dr. Shukry Na'amnieh by Dr. Shukry Na'amnieh The transformation of non-natural compounds by enzymes, biocatalysis, has several advantages over a chemical one. It is, by default, stereospecific. It is likely to be regiospecific, allowing a reaction to be carried out on one part of a complex molecule, leaving the rest left untouched. A biocatalytic reaction can often achieve results in one pot that would take three or four chemical steps. We strongly believe that our chemoenzymatic processes will be for you an ideal opportunity and an extension to your laboratories to accelerate and further your scientific discoveries and to expand your IP and product portfolio. We are confident that our biocatalysis group can be a reliable partner for your company to fully exploit our internal programs as well as in one or all of the following areas: · Identification and evaluation of relevant enzymatic process routes · Biocatalysis: Enzymatic synthesis of chiral products Capabilities: · A broad collection of more than 250 biocatalysts · Recombinant R- and S-Oxidoreductases, Lipases, Esterases, Amine dehydrogenases and Amidases · Whole - Cell biotransformation, Escherichia coli, Sacharomyces cerevisiae, Candida Boidinii, Candida Parapsilosis, Hansenula Polymorpha · Various Enzyme libraries, which have been created based on the wildtype sequences · Fermentor, GC's, HPLC's, UV-VIS-Spectrometry, IR-Spectrometer · Molecular biology Labs, S1, Purification and Analysis Labs, Cultivation Labs · Reactors 100-1000 Liters · Production under cGMP if required For questions regarding technology please contact: For inquiries/orders please contact: X-Zyme GmbH Life Science Center Dr. Shukry Na'amnieh Merowingerplatz 1A 40225 Düsseldorf Phone +49.(0)211.3 39 89 46 Fax +49.(0)211.33 67 96 69 Email web@x-zyme.com Web www.x-zyme.com UnaveraChemLab GmbH Am Ländbach 20 82481 Mittenwald Phone +49.(0)88 23.13 51 Fax +49.(0)88 23.34 49 Email sales@unavera.de Web www.unavera.de
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Aaron Chemistry GmbH Gmunder Straß
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IMPRESSUM 4 5 Aaron Chemistry GmbH
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8 9 Unternehmensportrait der Unaver
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12 Produktgruppen/Product Line Inde
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16 ALCOHOLES ALCOHOLES U-1131 U-724
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20 AMINES AMINES U-1119 CAS Nr.: U-
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24 CARBOXYLIC ACID DERIVATIVES U-10
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28 CINNAMIC ACIDS U-1081 CAS Nr.: U
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32 HALOGENIDES U-1019 CAS Nr.: U-10
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36 SALTS U-1079 U-1085 U-1084 U-104
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ACETOPHENONES ACETOPHENONES 40 450
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AMINOALCOHOLES AMINOALCOHOLES 44 90
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ANILINES ANILINES 48 1027 4-Benzylo
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ANILINES AROMATES 52 1047 3-Methyl-
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AROMATES AZIDES 56 267 3,4,5-Trimet
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BENZALDEHYDES BENZALDEHYDES 60 159
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BENZALDEHYDES BENZOIC ACIDS 64 135
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BENZOIC ACIDS BENZOIC ACIDS 68 1099
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BENZOPHENONES BENZOPHENONES 72 184
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BENZYLALCOHOLES BENZYLALCOHOLES 76
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BENZYLAMINES BENZYLAMINES 80 115 4-
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BENZYLHALOGENIDES BENZYLHALOGENIDES
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BORONIC ACIDS BORONIC ACIDS 88 9064
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BORONIC ACIDS BORONIC ACIDS 92 9061
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CHLOROACETIC ACID DERIVATIVES CINNA
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CINNAMIC ACIDS CINNAMIC ACIDS 100 1
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CYCLOHEXANONES HETEROCYCLIC ACETOPH
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HETEROCYCLIC CARBOXYLIC ACIDS IMIDA
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IMIDAZOLIUM SALTS IONIC LIQUIDS 112
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NICOTINIC ACIDS NICOTINIC ACIDS 116
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NITRILES NITRILES 120 313 4-Chlorob
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NITRILES NITRILES 124 264 2-Fluorob
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128 PHENETHYLAMINES 434 Purity: CAS
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132 PHENOLES 703 Purity: CAS Nr.: 7
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136 PHENYLACETIC ACIDS 569 Purity:
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140 PIPERAZINES 403 Purity: CAS Nr.
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156 PIPERAZINES 78 Purity: CAS Nr.:
Page 81 and 82: 160 PIPERAZINES 82 Purity: CAS Nr.:
Page 83 and 84: 164 PIPERAZINES 188 Purity: CAS Nr.
Page 95 and 96: 188 PIPERIDINES 217 Purity: CAS Nr.
Page 97 and 98: 192 PIPERIDINES 4034 Purity: CAS Nr
Page 99 and 100: 196 PIPERIDINES 530 Purity: CAS Nr.
Page 101 and 102: 200 PIPERIDONES 611 Purity: CAS Nr.
Page 103 and 104: 204 PYRIDINES 772 Purity: CAS Nr.:
Page 105 and 106: 208 PYRIMIDINES 1015 Purity: CAS Nr
Page 107 and 108: 212 RADIOPHARMACEUTICAL PRECURSORS
Page 109 and 110: 216 RADIOPHARMACEUTICAL PRECURSORS
Page 111 and 112: 220 SPECIAL ALCOHOLES 746 Purity: C
Page 113 and 114: 224 SPECIAL AMINES 50236 Purity: CA
Page 115 and 116: 228 SPECIAL AMINES 527 Purity: CAS
Page 117 and 118: 232 SPECIAL CARBOXYLIC ACIDS 210 Pu
Page 119 and 120: 236 THIOAMIDES 90301 Purity: CAS Nr
Page 125 and 126: STICHWORTVERZEICHNIS/KEYWORD INDEX
Page 127 and 128: 252 STICHWORTVERZEICHNIS/KEYWORD IN
Page 129 and 130: CAS-NR.-VERZEICHNIS/CAS-NO. INDEX C
Page 131: 260 Company Portrait of UnaveraChem
Page 135 and 136: 268 269 Weitere CASID-Interessierte
Page 137 and 138: 272 DIENSTLEISTER Concept/Realizati
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