Mesoporous silica- and silicon-based materials ... - Helda - Helsinki.fi

Contents
Abstract i
Acknowledgements ii
List of original publications v
Abbreviations and symbols vi
1 Introduction 1
2 Review of the literature 4
2.1 Processing amorphous drug formulations 4
2.1.1 Melt methods 5
2.1.2 Solvent methods 7
2.1.3 Other methods 8
2.2 Properties of mesoporous silicon and silica materials 9
2.2.1 Methods of fabrication 9
2.2.2 Structural differences 10
2.2.2.1 Pore morphology 11
2.2.2.2 Surface chemistry 12
2.2.3 Biological safety 13
2.2.3.1 In vitro studies 14
2.2.3.2 In vivo studies 18
2.3 Mesoporous materials in drug delivery 20
2.3.1 Modifying the drug release rate with particle properties 20
2.3.2 Controlled drug release 22
2.3.2.1 Surface functionalization 22
2.3.2.2 Stimuli-responsive methods 23
2.3.3 In vivo applications 25
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