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Page 1 and 2:
Division of Pharmaceutical Technolo
Page 3 and 4:
Abstract New chemical entities with
Page 5 and 6:
Contents Abstract i Acknowledgement
Page 7 and 8:
List of original publications This
Page 9:
PAMPA parallel artificial membrane
Page 12 and 13:
lipophilic drugs. The drug molecule
Page 14 and 15:
2 Review of the literature 2.1 Proc
Page 16 and 17:
the crystalline API into amorphous
Page 18 and 19:
Other solvent methods Spray-freeze-
Page 20 and 21:
particles grow and finally start to
Page 22 and 23: 2.2.2.2 Surface chemistry Surface i
Page 24 and 25: Cancer (IARC) has classified inhale
Page 26 and 27: investigation. The cytotoxicity of
Page 28 and 29: The shape and surface properties of
Page 30 and 31: egard to the material toxicity. The
Page 32 and 33: entrapment of the molecules inside
Page 34 and 35: thus leaving the pores open for the
Page 36 and 37: ongoing and it is anticipated that
Page 38 and 39: 4 Experimental Detailed description
Page 40 and 41: 4.1.3 Cell culture (IV) Human colon
Page 42 and 43: espective original publications (I-
Page 44 and 45: Monolayer integrity was controlled
Page 46 and 47: groups/nm 2 , OH, is generally high
Page 48 and 49: However, the HPLC drug loading degr
Page 50 and 51: Figure 7. Release profiles of ibupr
Page 52 and 53: evaluated at pH 1.2 in publication
Page 54 and 55: 6 Conclusions In this study several
Page 56 and 57: Bahl, D., Bogner, R.H., 2006. Amorp
Page 58 and 59: Chang, J.-S., Chang, K.L.B., Hwang,
Page 60 and 61: Gomez-Orellana, I., 2005. Strategie
Page 62 and 63: Iler, R.K., 1979. Chemistry of sili
Page 64 and 65: Leuner, C., Dressman, J., 2000. Imp
Page 66 and 67: Passerini, N., Albertini, B., Gonz
Page 68 and 69: Salonen, J., Lehto, V.-P., 2008. Fa
Page 70 and 71: Takeuchi, H., Nagira, S., Yamamoto,
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