Prof. Dr. Martin MÜLLER

Martin Müller
PhD 1991 University of Heidelberg, Germany,
Postdoctoral work at the DKFZ and the Loyola
University Chicago. At the DKFZ since 1998.
Papillomavirus Vaccines
Current Research
Infection with certain types of Human
Papillomaviruses are considered the
main risk factor for the development of
cervical cancer in women. Recently,
two commercial vaccines for the
prevention of infection by the major
high risk papillomavirus types 16 and
18 became available. Although both
vaccines are highly efficient, there are
a number of potential shortcomings
that could be addressed in second
generation vaccines: (i) production
should be more cost effective, (ii) the
administration should be non-invasive,
(iii) the vaccine should provide
protection against multiple HPV types,
(iv) vaccines for the treatment of
exisiting infections need to be
developed, (v) the vaccines should
provide long term or life long
protection.
Contact:
Priv. Doz. Dr. Martin Müller
Programme of Infection & Cancer
Im Neuenheimer Feld 242
69120 Heidelberg
Germany
Tel.: +49 6221 424628
Fax.:+49 6221 424932
email: Martin.Mueller@dkfz.de
personal home page:
www.dkfz.de/de/f035
Current and Future Project
Adeno-accociated viruses for genetic
vaccination. HPV crossprotective
vaccines. Oral immunization against
HPV. Production of HPV antigens in
transgenic plants.
Selected Publications
-Elisa Kieback and Martin Müller
(2006)
Factors influencing subcellular
localization of the human
papillomavirus L2 minor structural
protein. Virology. 2006, 345, 199-208
-Stephanie Mattil-Fritz, Hermann
Müller, Doreen Scharner, Konrad
Piuko, Nadja Thönes, Lutz Gissmann,
and Martin Müller (2007)
Immunotherapy of equine sarcoid:
Phase I dose escalation trial for the
use of chimeric papillomavirus-like
particles. J. Gen. Virology, in press
-Nadja Thönes and Martin Müller
(2007)
Oral immunization with different
assembly forms of the HPV 16 major
capsid protein L1 induces neutralizing
antibodies and cytotoxic Tlymphocytes.
Virology
-Maja Gasparic, Ivonne Rubio, Nadja
Thönes, Lutz Gissmann and Martin
Müller (2007)
Protective DNA Immunization against
Multiple Papillomavirus Types
Vaccine, 25, 4540-4453

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