Dr. Veerle Verjans Nefroloog - Orpadt
Dr. Veerle Verjans Nefroloog - Orpadt
Dr. Veerle Verjans Nefroloog - Orpadt
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Fysiologie van Incretines<br />
Ingestion of<br />
food<br />
GI tract<br />
Release of<br />
incretin gut<br />
hormones<br />
Active<br />
GLP-1 and GIP<br />
Pancreas<br />
Beta cells<br />
Alpha cells<br />
Glucose dependent<br />
Insulin<br />
from beta cells<br />
(GLP-1 and GIP)<br />
Glucagon<br />
from alpha cells (GLP-<br />
1)<br />
Glucose dependent<br />
Insulin<br />
increases<br />
peripheral<br />
glucose<br />
uptake<br />
Increased insulin and<br />
decreased<br />
glucagon<br />
reduce<br />
hepatic<br />
glucose output<br />
Blood<br />
glucose control<br />
Adapted from Brubaker PL, <strong>Dr</strong>ucker DJ Endocrinology 2004;145:2653–2659; Zander M et al Lancet 2002;359:824–830; Ahrén B Curr Diab Rep 2003;3:365– 20<br />
372; Buse JB et al. In Williams Textbook of Endocrinology. 10th ed. Philadelphia, Saunders, 2003:1427–1483.
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