Dr. Veerle Verjans Nefroloog - Orpadt
Dr. Veerle Verjans Nefroloog - Orpadt
Dr. Veerle Verjans Nefroloog - Orpadt
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Steady state levels<br />
van liraglutide en exenatide<br />
Normalised concentration (%)<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
exenatide BD<br />
T½ 2.4 h<br />
liraglutide OD<br />
T½ 13 h<br />
4.0 4.5 5.0 5.5 6.0 6.5 7.0<br />
Time after first dose (days)<br />
Modelling of plasma concentration of active drug vs. maximal concentration at steady state achieved following clinically relevant doses<br />
OD or BD. Based on published exenatide data and modelled liraglutide data.<br />
Jonker et al. Diabetes 56(Suppl. 1):A160<br />
50<br />
40<br />
30<br />
20<br />
10<br />
pM nM<br />
0<br />
28<br />
24<br />
20<br />
16<br />
12<br />
8<br />
0<br />
Absolute concentration
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