The Toxicologist - Society of Toxicology

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Annual Meeting & ToxExpo Society of Toxicology 53 rd Phoenix, Arizona Deadline for Proposals for SOT 2014 Annual Meeting Sessions: April 30, 2013 Session Types Continuing Education—Emphasis on quality presentations of generally accepted, established knowledge in toxicology Note: CE courses will be held on Sunday. Symposia—Cutting-edge science; new areas, concepts, or data Workshops—State-of-the-art knowledge in toxicology Roundtables—Controversial subjects Historical Highlights—Review of an historical body of science that has impacted toxicology Informational Sessions—Scienti c planning or membership development Education-Career Development Sessions— Sessions that provide the tools and resources to toxicologists that will enhance their professional and scienti c development Regional Interest—Central topics of relevance that describe public health and/or ecological problems of a particular region Submit your proposal online at www.toxicology.org March 23–27, 2014 Phoenix Convention Center Why Submit a Proposal? 1. To present new developments in toxicology. 2. To provide attendees an opportunity to learn about state-of-the-art technology and how it applies to toxicological research. 3. To provide attendees an opportunity to learn about the emerging elds and how they apply to toxicology.
The Toxicologist Supplement to Toxicological Sciences 52nd Annual Meeting and ToxExpoTM 52nd Annual Meeting and ToxExpoTM 52nd Annual Meeting and ToxExpoTM ISSN 1096-6080 Volume 132, Issue 1 March 2013 March 10–14, 2013 • San Antonio, Texas www.toxsci.oxfordjournals.org An Official Journal of the Society of Toxicology www.toxicology.org
Page 1: The Toxicologist Supplement to Toxi
Page 5 and 6: 1 A Refresher of Immunoglobulin and
Page 7 and 8: 12 Understanding Toxic Neuropathy i
Page 9 and 10: SWCNTs (raw FeSWCNT or purified cSW
Page 11 and 12: 34 Computational Systems Biology Mo
Page 13 and 14: driving allergic airway response, c
Page 15 and 16: E100, E0 vapors caused no overt mat
Page 17 and 18: in heart rate, blood pressure, brea
Page 19 and 20: hearts showed a coronary artery dis
Page 21 and 22: inducible NADPH oxidase dependent m
Page 23 and 24: 93 Simulated Metabolism in the Lang
Page 25 and 26: (female pubertal assay, OPPTS 890.1
Page 27 and 28: 112 Endocrine Disruption Potential
Page 29 and 30: The incorporation of in vitro data
Page 31 and 32: was validated by the following resu
Page 33 and 34: 139 A Systematic Analysis of ToxCas
Page 35 and 36: 148 Mucosa-Associated Enteropathoge
Page 37 and 38: 158 The Cannabinoid WIN 55, 212-2 D
Page 39 and 40: signaling. ARNT is expressed as two
Page 41 and 42: 177 Modifying Effect of Glycidol Fa
Page 43 and 44: 24 and 72 hours post treatment. We
Page 45 and 46: line and the effects of the haploty
Page 47 and 48: organ weight, gross findings, or hi
Page 49 and 50: 215 Acute and Delayed Effects of In
Page 51 and 52: 224 Interaction of Human Bronchial
Page 53 and 54:
espiratory and olfactory mucosal le
Page 55 and 56:
hyperresponsiveness to MCh aerosol
Page 57 and 58:
shown that the collagen content is
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fect is consistently higher in male
Page 61 and 62:
surrogate) in the presence or absen
Page 63 and 64:
of field controls were 46.3 ± 5 μ
Page 65 and 66:
290 Interpretation of Multiroute Da
Page 67 and 68:
18.8 ml/min/kg) were more similar t
Page 69 and 70:
Urinary excretion at 72 h post admi
Page 71 and 72:
into a physiologically based pharma
Page 73 and 74:
327 Cytochrome P450 Gene Transcript
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(LD50 = 25 μM). Both pre- and post
Page 77 and 78:
345 Prediction of Human Equivalent
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only remnants, including utriculi a
Page 81 and 82:
363 MicroRNA Microarray Analysis of
Page 83 and 84:
371 Mechanisms of Vesicating Agent
Page 85 and 86:
381 Effect of Asbestos Exposure on
Page 87 and 88:
PCB126 at doses of 0.1; 1 or 10μg/
Page 89 and 90:
399 Immunotoxicity of the Nasal Ass
Page 91 and 92:
407 The Dermal Exposure to Silica N
Page 93 and 94:
416 Exposure to Triclosan Augments
Page 95 and 96:
ventilation. Two independent method
Page 97 and 98:
the German Federal Ministry of Educ
Page 99 and 100:
443 Sonolytic Degradation of Pluron
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mice were anesthetized and lungs an
Page 103 and 104:
mulations propelled the development
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fluorophore was removed by ultrafil
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The objective of this study was: (1
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489 Preliminary Toxicokinetics of N
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were twice as much susceptible to d
Page 113 and 114:
improve the fit to the available in
Page 115 and 116:
lead to i) a significant reduction
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(CYP1A1). Induction of this enzyme
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We have described a role for miRNAs
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individual treatment. Both compound
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554 Toxicogenomic Analysis of Envir
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563 Global Gene Expression Changes
Page 127 and 128:
572 Preliminary Steps in a Whole Mi
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581 Chemical Characterization of Co
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fungicides. Studies indicated that
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of the used soil. Mortality and som
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from repeated doses, and the utilit
Page 137 and 138:
618 Use of a Physiologically-Based
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emained as such through 24 hours po
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number of hepatic neutrophils remai
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human PRL (150 ng/ml) or human PL (
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time and Nrf2 -dependent increase i
Page 147 and 148:
664 Hepatic Flavin-Containing Monoo
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673 Hypoxia Perturbs PCB-Induced Ar
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factor tool predicted the activatio
Page 153 and 154:
to 50 μM Cd for 4 or 8 hours. Glob
Page 155 and 156:
701 Reprogramming of the HepG2 Geno
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a process that was tested using di(
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a. Integrated Mode-of-Action (MoA)
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MitoPark mice also showed a dramati
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738 Human Antibodies Can Cross Guin
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Based on an initial 2 day dose-resp
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non-invasive methodology to measure
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768 Air Quality Impacts of Natural
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pathology by disrupting the normal
Page 173 and 174:
pathways. Through these activities
Page 175 and 176:
Approval of the Medical Research Et
Page 177 and 178:
ile duct hyperplasia and hepatocell
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degradation enzymes, matrix metallo
Page 181 and 182:
825 Image-Derived Models of Subcell
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used a number of strategies to mani
Page 185 and 186:
ange of the population. It is gener
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858 Flexible and Transparent Comput
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available tool that provides a foun
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876 Web-Based Benchmark Dose Modeli
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885 A Mechanistic Approach to Under
Page 195 and 196:
observed pharmacokinetic difference
Page 197 and 198:
Funding: EU-FP7 (ENFIRO; grant agre
Page 199 and 200:
913 Protective Role of Carnosine Ag
Page 201 and 202:
measurable neurobehavioral endpoint
Page 203 and 204:
For the TLDA- derived PCR data, a m
Page 205 and 206:
samples within each group, strongly
Page 207 and 208:
950 Smoking-Induced microRNA Change
Page 209 and 210:
IL-1α. This approach has been adva
Page 211 and 212:
969 Collaborative Project in JCIA f
Page 213 and 214:
977 Predicting Eye Irritation of Ag
Page 215 and 216:
organophosphates, organochlorines,
Page 217 and 218:
996 Does the Barker Hypothesis Appl
Page 219 and 220:
1005 Effects of Di(2-Ethylhexyl)-Ph
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compared to single housing. In conc
Page 223 and 224:
1023 Hyperactivity of Rat and Mouse
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1 and Rho kinase inhibitor (HA1077)
Page 227 and 228:
and subcutaneous and/or dermal infl
Page 229 and 230:
inding in the liver, which involves
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tion, glycolysis, and amino acid me
Page 233 and 234:
was isolated from frozen samples, a
Page 235 and 236:
1079 MicroRNA Regulation of Alcohol
Page 237 and 238:
an inducer of hyperglycemia) to cha
Page 239 and 240:
1097 Deletion of Hepatocyte Nuclear
Page 241 and 242:
study, we validated this short-term
Page 243 and 244:
ferentiation and glucose metabolism
Page 245 and 246:
tients treated with desipramine, th
Page 247 and 248:
from mesenteric and uterine vascula
Page 249 and 250:
Akt2 function preservation. For mec
Page 251 and 252:
1152 Serum and Hepatic Alkaline Pho
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fold) with a dissociation constant
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1171 Fin Whale Cells Are More Resis
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develop analytical means to measure
Page 259 and 260:
and location of ROS, and 2) cell an
Page 261 and 262:
25% of patients receiving Imatinib
Page 263 and 264:
lesions originate from is not clear
Page 265 and 266:
Our analysis detected and corrected
Page 267 and 268:
and APC. Results: Etirinotecan pego
Page 269 and 270:
to the amount of fecal contaminatio
Page 271 and 272:
1243 A High-Throughput Analytical M
Page 273 and 274:
1252 Using Doubly-Labeled Water Ene
Page 275 and 276:
implying that BPA is toxic to human
Page 277 and 278:
1271 The Aryl Hydrocarbon Receptor
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1280 Aryl Hydrocarbon Receptor (AhR
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genes, suggesting a role for AHRRa
Page 283 and 284:
and cellular proliferation. Underst
Page 285 and 286:
1307 Toxicological Evaluation of th
Page 287 and 288:
in blood as confirmed by a componen
Page 289 and 290:
activation of scavenger receptor B
Page 291 and 292:
AgNPs in dilutions of an environmen
Page 293 and 294:
after dosing for TEM analysis. Imag
Page 295 and 296:
various cell-lines. However, the da
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and the presence of leukocytes and
Page 299 and 300:
1374 PCB 95 and IFN-gamma Exert Opp
Page 301 and 302:
on estrogens. It is not known how t
Page 303 and 304:
cell number, was reduced at PND10,
Page 305 and 306:
1402 Repeated Exposure to Paraquat
Page 307 and 308:
weeks (3 injections/week). We recor
Page 309 and 310:
1421 Differential Antagonism of Tet
Page 311 and 312:
of the syringe suggesting loss due
Page 313 and 314:
1439 Interleukin 17 Responses Induc
Page 315 and 316:
strains were exposed in triplicate
Page 317 and 318:
1458 An In Vitro Placental Model Us
Page 319 and 320:
Phagotest® (Glycotope Biotechnolog
Page 321 and 322:
1477 Use of An In Vitro Flow Cytome
Page 323 and 324:
1487 Evaluation of Genotoxicity of
Page 325 and 326:
commonly used in textile industry.
Page 327 and 328:
under hamster S9-activated and non-
Page 329 and 330:
neutrophilic to eosinophilic respon
Page 331 and 332:
1524 The Palmitoylation of Meh1, a
Page 333 and 334:
for Dark, Pb afforded 0.607 mg/kg f
Page 335 and 336:
to 5.4 or 54.1 mg/m3, respectively)
Page 337 and 338:
1552 Body-Residue Based Environment
Page 339 and 340:
1561 Identifying No Observed Effect
Page 341 and 342:
studies/endpoints led by academic i
Page 343 and 344:
1580 In Vitro Episkin Skin Corrosio
Page 345 and 346:
RXR, opening the possibility that t
Page 347 and 348:
1601 Enhanced Susceptibility of Fat
Page 349 and 350:
potential to impact the safety asse
Page 351 and 352:
A dataset of over 200 compounds cov
Page 353 and 354:
that link in vivo outcomes (includi
Page 355 and 356:
in humans, occurring in eight newbo
Page 357 and 358:
novel mechanisms of action where th
Page 359 and 360:
their homes, learn about historic a
Page 361 and 362:
toxicology where Tox-21c could have
Page 363 and 364:
compounds and Colcemide as an aneug
Page 365 and 366:
dose dependent increases (p< 0.05)
Page 367 and 368:
1707 Dose Response and Temporality
Page 369 and 370:
several cells, including cancer cel
Page 371 and 372:
1727 Characterization of Cigarette
Page 373 and 374:
1736 Coating Nanoporous Alumina: Ce
Page 375 and 376:
1745 Comparison of Toxicity of Bare
Page 377 and 378:
using microscopy, cytotoxicity test
Page 379 and 380:
ona, and 1.8 folds lower than the d
Page 381 and 382:
RESULTS: Electronic microscopy stud
Page 383 and 384:
effect of its flavonolignans. Becau
Page 385 and 386:
These results suggest that mollugin
Page 387 and 388:
m266.2 were not different from thos
Page 389 and 390:
and associated drug accumulation, w
Page 391 and 392:
1820 Application of Canine Kidney T
Page 393 and 394:
1829 Effect of Body-Weight Loading
Page 395 and 396:
mechanisms of cell death, we invest
Page 397 and 398:
post-translational modifications of
Page 399 and 400:
as oxidative stress, Ca2+ dysregula
Page 401 and 402:
studies assessing cognitive and mot
Page 403 and 404:
spine density of hippocampal pyrami
Page 405 and 406:
individually or in combinations, in
Page 407 and 408:
1893 A Comparative Study on Renal T
Page 409 and 410:
same hand and between washed and no
Page 411 and 412:
1911 Molecular, Cellular, and Histo
Page 413 and 414:
1920 Endocrine Modulatory Effects o
Page 415 and 416:
CYP19 mRNA levels were observed wit
Page 417 and 418:
males and females. In efforts to bl
Page 419 and 420:
worker’s capacity to adapt to hea
Page 421 and 422:
from different studies indicates th
Page 423 and 424:
1966 Associations between Carcinoge
Page 425 and 426:
1975 Assessment of the Impacts of C
Page 427 and 428:
For this analysis, nine PCBs with d
Page 429 and 430:
1993 PBDE-100 Induces Mitochondrial
Page 431 and 432:
2002 Cyp1b1-Deficiency Alters Struc
Page 433 and 434:
enzymes and xenobiotic transporters
Page 435 and 436:
protected against p-aminophenol (PA
Page 437 and 438:
status has shown much promise. Howe
Page 439 and 440:
esidues in proteins. The significan
Page 441 and 442:
where no peak (same action througho
Page 443 and 444:
were exposed to ethyl-alcohol via t
Page 445 and 446:
2066 Validation of a 7-Color Flow C
Page 447 and 448:
tive and detoxification genes. In a
Page 449 and 450:
activated B cells and BCL-6, a tran
Page 451 and 452:
later time points. Therefore, BPA e
Page 453 and 454:
2102 Brominated Diphenyl Ether-47 I
Page 455 and 456:
distribution and excretion or other
Page 457 and 458:
serum Inhibin B was never changed.
Page 459 and 460:
2130 Structural Changes in Various
Page 461 and 462:
Methods: Adult male Fisher 344 rats
Page 463 and 464:
asked what genes are involved in Me
Page 465 and 466:
study examined whether combined Pb+
Page 467 and 468:
elated to dried blood spots and mas
Page 469 and 470:
15(R) D2 increased by 3.3 / 2.3-fol
Page 471 and 472:
otic transcription factors nuclear
Page 473 and 474:
genes. On the other hand, the creat
Page 475 and 476:
2203 Resistance to Dioxin-Induced H
Page 477 and 478:
data because the human data were no
Page 479 and 480:
odent cancer bioassay of MTBE in dr
Page 481 and 482:
(BMCL) estimates were extrapolated
Page 483 and 484:
outcomes which differ from those ou
Page 485 and 486:
2250 Validation of the Yeast Estrog
Page 487 and 488:
in cell index, indicative of cytoto
Page 489 and 490:
platform maybe most appropriate for
Page 491 and 492:
200, 1000, or 2000 parts per billio
Page 493 and 494:
2288 Paradoxical Effects of Ongoing
Page 495 and 496:
for intracellular tracking of GR us
Page 497 and 498:
2306 Evaluating Arsenic Speciation
Page 499 and 500:
2316 Integrative Toxicopathological
Page 501 and 502:
improve food safety is to reduce ex
Page 503 and 504:
ased on human oral challenge studie
Page 505 and 506:
2344 The Global Burden of Disease C
Page 507 and 508:
HDACs had opposite effects, suggest
Page 509 and 510:
useful in human health risk assessm
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1.7% in mucosal side. These results
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2381 Silica Nanoparticles Induce Ac
Page 515 and 516:
have been well-demonstrated to be o
Page 517 and 518:
2400 Fibrinogen: A New Kid on the B
Page 519 and 520:
all critical factors. Vital organ s
Page 521 and 522:
identifying QSARs that are applicab
Page 523 and 524:
after the training, and the percent
Page 525 and 526:
sham control group was included to
Page 527 and 528:
after 15 min incubation with the C8
Page 529 and 530:
2462 Nonhuman Primate Sexual Maturi
Page 531 and 532:
2472 Modeling Human Genetic Variabi
Page 533 and 534:
two subgroups, hippocampus were dis
Page 535 and 536:
2495 Physiologically-Based Pharmaco
Page 537 and 538:
plexes with important functional gr
Page 539 and 540:
Notes SOT 2013 AnnuAl MeeTing 535
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Author Index (Continued) B Baan, R
Page 543 and 544:
Author Index (Continued) Cassis, L
Page 545 and 546:
Author Index (Continued) Dodmane, P
Page 547 and 548:
Author Index (Continued) Gilpin, S
Page 549 and 550:
Author Index (Continued) Huh, G 18
Page 551 and 552:
Author Index (Continued) Krantz, Q
Page 553 and 554:
Author Index (Continued) Martin, S
Page 555 and 556:
Author Index (Continued) Niklas, J
Page 557 and 558:
Author Index (Continued) Rana, P 2
Page 559 and 560:
Author Index (Continued) Shin, K 6
Page 561 and 562:
Author Index (Continued) Touissant,
Page 563 and 564:
Author Index (Continued) Wormser, U
Page 565 and 566:
Abstract Keyword Index (Continued)
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Page 569 and 570:
Page 571 and 572:
Page 573 and 574:
Page 575 and 576:
Page 577 and 578:
Page 579 and 580:
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