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Chapter 2 34 Table 2.2 Clinical, endocrine and menstrual cycle characteristics (median and range) in 40 normo- ovulatory women presenting with either single (n=16) or multiple (n=24) dominant follicle (≥ 10 mm) development following exogenous recFSH starting on either cycle day 3, 5 or 7. Dominant follicle P a Single Multiple n 16 24 * Age (yrs) 29 (20-34) 29 (21-35) - BMI (kg/m 2 ) 23 (19-27) 22 (19-27) - Cycle length (d) 28 (26-31) 28 (25-31) - Cycle day 3 FSH (IU/l) 7.0 (2.8-12.2) 7.2 (3.3-13.5) - E 2 (pmol/l) 137 (93-264) 153 (64-404) - Inhibin B (ng/l) 114 (26-179) 91 (12-213) - Day of hCG FSH (IU/l) 6.6 (4.5-20.4) 6.0 (4.5-15.0) - LH (IU/l) 7.4 (2.0-49.3) 4.6 (0.3-57.2) - E 2 (pmol/l) 793 (470-1353) 1176 (536-2840) 0.02 P (nmol/l) 4.1 (2.4-27.3) 4.3 (1.4-11.7) - Inhibin A (ng/l) 50 (28-143) 82 (27-224)
Number of dominant follicles 8 6 4 2 0 18 20 22 Intervention in the normal menstrual cycle 35 BMI (kg/m²) Serum hormone levels Figure 2.4 shows the hormone concentrations during the follicular phase (separate for women presenting with single or multiple dominant follicles), comparing group CD 3, CD 5 and CD 7. In group CD 7, FSH levels of the subjects with multifollicular growth 24 r = - 0.44 P = 0.007 Figure 2.2 Distribution of the number of follicles (≥ 10 mm) observed in both ovaries on the day of hCG administration related to BMI in 40 normo-ovulatory women. Subjects received low daily doses of exogenous FSH during the follicular phase (starting on either cycle day 3, 5 or 7). Pearson’s correlation: r = -0.44, P = 0.007. Follicle diameter (mm) 19 15 11 7 -6 Single DF (n=16) Multiple DF (n=24) -4 -2 days before hCG 26 hCG Figure 2.3 Diameter (mean ± SEM) of the largest dominant follicle in the follicular phase of intervention cycles in 40 normo-ovulatory women receiving low daily doses of exogenous FSH, starting on either cycle day 3, 5 or 7. The lines represent the subjects presenting with single- or multiple dominant follicle development (≥ 10 mm). The scale on the x-axis is expressed as days prior to late follicular phase administration of hCG. DF = dominant follicle(s). 28
Page 1 and 2: Aspects of Mono- and Multiple Domin
Page 3 and 4: Aspects of Mono- and Multiple Domin
Page 5: Ter nagedachtenis aan mijn vader Vo
Page 8 and 9: 4.2.1. Introduction 69 4.2.2. Mater
Page 10 and 11: SRY sex-determining region of the Y
Page 13 and 14: 1.1. General introduction Introduct
Page 15 and 16: Introduction and objectives 15 olog
Page 17 and 18: Mid 1940’s Initial (unsuccessful)
Page 19 and 20: tonic growth phase >120 days growth
Page 21 and 22: Introduction and objectives 21 WHO
Page 23 and 24: Introduction and objectives 23 sibl
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Page 29 and 30: Intervention in the normal menstrua
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Page 51: Chapter 3 Mild ovarian stimulation
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Page 56 and 57: Chapter 3 56 Group A: Group B: Grou
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FSH treatment duration (days) FSH r
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Alternative approaches to disturbed
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General discussion General discussi
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General discussion 93 the developin
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General discussion 95 study in term
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General discussion 97 ian response
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References
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References 102 Beckers NG, Macklon
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References 104 Dunaif A, Graf M, Ma
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References 106 Gerris J, De Neubour
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References 108 Hughes EG, Collins J
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References 110 Mannaerts B, de Leeu
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References 112 Olivennes F and Fryd
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References 114 Sullivan MW, Stewart
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References 116 Whiteford LM and Gon
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Summary Chapter 1 Summary 119 The i
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Summary 121 resulted in pregnancy r
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Samenvatting Hoofdstuk 1 Samenvatti
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Samenvatting 125 op cyclusdag 2 of
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Publications and presentations
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Publications and presentations 130
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Dankwoord Dankwoord 133 Mijn promot
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Dankwoord 135 Dank je voor het bijb
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Dankwoord 137 Zonder ondersteuning
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Dankwoord 139 Lieve Elly en Joost,
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Curriculum vitae auctoris Curriculu
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