Plant Alkaloids Atallah F. Ahmed

A number of semi-synthetic lysergic acid derivatives act by
stimulation of dopamine receptors in the brain and are used in
Parkinson’s disease. Bromocriptine (2-bromo-α-ergocryptine) are
all used in this way.
Bromocriptine also inhibit release of prolactin by the pituitary,
and can thus suppress lactation and be used in the treatment of
breast tumours tumours.
Methysergide is a semi-synthetic analog of ergometrine, having
potent 5-HT antagonist and employed in prophylaxis of migraine.
Lysergic acid diethylamide or LSD, the widely abused
hallucinogen is the most active and specific psychotomimetic drug,
and is a mixed agonist–anatagonist at 5-HT receptors, interfering
with the normal processes. An effective oral dose is from 30 to 50
μg.
It intensifies perceptions and distorts them.. Experiences can vary
from beautiful visions to living nightmares, sometimes lasting for
days. Although the drug is not addictive, it can lead to
schizophrenia and there is danger of serious physical accidents
occurring whilst the user is under the influence of the drug. It has
Atallah F. Ahmed, PhD 2010
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been used in psychoanalysis.
Atallah F. Ahmed, PhD 2010
LSD
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5/30/2010
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