Monther A - Sultan Qaboos University

Summary:
1
Curriculum Vitae
Dr. Raid J. Abdel-Jalil
Chemistry Department
Faculty of Science
Hashemite University
Zarka-Jordan
On Leave at:
Present address:
Chemistry Department
College of Science
Sultan Qaboos University
P B No: 36, P C 123
Muscat, Oman
___________________________________
+ 968-2414 1483 (office)
+968 920 89702 (mobile)
+968 24141469
jalil@squ.edu.om
http://www.squ.edu.om/tabid/7516/language/en-
US/Default.aspx
Associate professor in organic chemistry, 33 scientific publications, a post-doc in the
department of pharmacology at UCLA-USA and a Ph.D. from University of Tuebingen-
Germany

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Education
Postdoctoral Fellow University of California Los Angeles (UCLA)
2000-2001
Department of Pharmacology/ School of Medicine
Postdoctoral Fellow, Mentor: Prof. Tatsushi Toyokuni
Development of F-18 labeling agents for targeting biomolecules:
Synthesis and applications to the labeling of ODNs and antibody fragments
Ph.D. University of Tuebingen, Tuebingen (Germany),
1996 – 1999
Dissertation Title: "Anhydropyranoses as Chirons for Regio- and
Stereoselective Synthesis of Chiral Heterocyclic Systems,
(4→4)-Di(2,3-anhydropentopyranosides), 4-(4-Substituted-1-piperazinyl)-
2,3-anhydropentopyranosides and Cyclopentane Derivatives."
Advisor: Prof. Dr. Dr. h. c. Wolfgang Voelter
Honors: DAAD (Deutscher Akademischer Austausch Dienst-Germany)
Fellowship (1996-1999)
M.Sc. University of Jordan, Amman (Jordan)
1991 – 1995
Organic Chemistry
Thesis Title: "Synthesis and Bioassay of Some 5-Flouro-6-(1-
Piperazinyl)Benzimidazole"
Advisor: Prof. Dr. S. Sabri; Co-advisor: Prof. Dr. M. El-Abadelah
Honors: Fellowship from University of Jordan (1992-1994),
Fellowship from Hikma Pharmaceuticals Company (1992-1995).
B.Sc. University of Jordan, Amman (Jordan),
1988 – 1991
Chemistry

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Positions and Experience
1. Assistant Professor, Chemistry Department, College of Science, Sultan Qaboos University,
2008-present
2. Consulting Visitor, Chemistry Department, College of Science, Sultan Qaboos University,
2008-2009
3. Chairman, Chemistry Department, Faculty of Science, Hashemite University: 2007/2008.
4. Vice Dean, Faculty of Science, Hashemite University: 2006/2007.
5. Chairman, Chemistry Department, Faculty of Science, Hashemite University: 2005/2006.
6. Associate Professor (Organic Chemistry), Chemistry Department, Faculty of Science, Hashemite
University: 2007-present.
7. Assistant Professor (Organic Chemistry), Chemistry Department, Faculty of Science, Hashemite
University: 2001-2007.
8. Post-doc Fellow: Department of Pharmacology, School of Medicine, University of California at
Los Angeles: 2000-2001.
1. Asymmetric Synthesis
2. Heterocyclic synthesis
3. Microwave synthesis
4. Developing of new hpoxia PET tracers
Research interest
PUBLICATIONS LIST:
1. M. M. El-Abadelah, S. S. Sabri, M. H. Abu Zarga, R. J. Abdel-Jalil, “Substituted Benzimidazoles.
Synthesis and Properties of some 2-Aryl-5-fluoro-6-(4-methyl-1-piperazinyl)-1H-benzimidazoles”
Heterocycles, 41, 2713 (1995).
2. R. J. Abdel-Jalil, R. A. Al-Qawasmeh, W. Voelter “(4→4)-Di(2,3-anhydropentopyranosides), a
Novel Class of Potential Enzyme Inhibitors” Tetrahedron Lett. 39, 6155 (1998).
3. R. J. Abdel-Jalil, R. A. Al-Qawasmeh, Y. Al-Abed, W. Voelter“A Stereospecific Synthesis of
Tetra-Substituted Chiral Piperazines” Tetrahedron Lett. 39, 7703 (1998).
4. R. A. Al-Qawasmeh, R. J. Abdel-Jalil, T. H. Al-Tel, R. Thürmer, W. Voelter, “A Useful
Regioselective Approach to Episulfides via cis-oriented Anhydro Triflate Sugars”, Tetrahedron
Lett. 39, 8257 (1998).
5. R. A. Al-Qawasmeh, T. H. Al-Tel, R. J. Abdel-Jalil, R. Thürmer, W. Voelter*, “Anhydro Sugars
to Enantiomerically pure Building Blocks: Efficient syntheses of γ-Lactones and Furanoids”,
Polish J. Chem. 73, 71-75 (1999).
6. W. Voelter, R. Thürmer, R. A. Al-Qawasmeh, T. H. Al-Tel, R. J. Abdel-Jalil, Y. Al-Abed,
“Epoxy Pyranoses, Chiral Synthons for Versatile Regio- and Stereocontrolled Functionalizations”,
Polish J. Chem. 73, 55-69 (1999).
7. R. A. Al-Qawasmeh, T. H. Al-Tel, R. J. Abdel-Jalil, W. Voelter, “Carbohydrates to Heterocycles:
A new Strategy for the Synthesis of Enantiomerically Pure Pyridazines and Oxazines Derived from
Epoxypyranoside Scaffolds” Chem Letters, 541 (1999)

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8. Khalid M. Khan, Zafar S. Saify, Zeeshan, Abdullah Khan, Mansoor Ahmed, Muhammed Saeed,
Raid J. Abdel-Jalil, Gerald Grübler, Wolfgang Voelter, “Syntheses of Selected Quaternary
Phenacylbromopyridinium Compounds and their Biological Evaluation”, Z. Naturforsch. 54b,
1210-1218. ( 1999).
9. R. J. Abdel-Jalil, Raed Al-qauasmeh, Mustafa El-Abadelah, Salim Sabri and Wolfgang Voelter,
“Synthesis and Properties of 6-Flouro-7-(1-Methyl-4-piperazinyl)quionoxalines”, J. Heterocyl.
Chem., 37, 1273 (2000).
10. R. J. Abdel-Jalil, Muhammed Saeed and Wolfgang Voelter, “Synthesis and properties of some
substituted Anhydro Sugars”, Z. Naturforsch., 55b, 661-666 (2000).
11. Mustafa M. El-Abadelah, Salim S. Sabri, Monther Khanfar, Wolfgang Voelter, Raid J. Abdel-
Jalil, Calcia Maichele-Mossmer and Yousef Al-Abed, “Syntehsis and Properties of α-Thiagra. A
Substituted 5-(2-Thienyl)Pyrazolo[4,3-d]Pyrimidin-7-one Bioisotere of Viagra”, Heterocycles, 35
2643-2652 (2000).
12. Muhammed Saeed, R. J. Abdel-Jalil, Wolfgang Voelter, Mustafa El-Abadelah, " An expeditious
synthesis of optically pure 1,4,5,6-tetrahydro-as-triazines, fused to the carbohydrate skeleton”,
Chem. Letters, 7, 660-661 (2001).
13. R. J. Abdel-Jalil, Muhammed Saeed and Wolfgang Voelter, " An Expeditious Approach To Tri
Substituted Chiral Thiazolines”, Tetrahedron Letters, 42, 2435-2437 (2001).
14. M. Saeed, M. Abbas, R. J. Abdel-Jalil, M. Zahid and W. Voelter, “ A convenient Method for the
Synthesis of Cylic Trithiocarbonates on Carbohydrate Scaffolds”, Tetrahedron Letters, 44, 315-
317 (2003).
15. R. J. Abdel-Jalil, W. Voelter and M. Saeed, " A novel Method for the Synthesis of 4(3H)-
Quinazolinones”, Tetrahedron Letters, 45, 3475-3476 (2004).
16. S. T. Shah, R. J. Abdel-Jalil, K. Khan, A. Heinrich, M. Richter and W. Voelter, “ Regioselective
Conversion of Anhydro Sugars into Halohydrins and X-ray study”, Z. Naturforsch., 59b, 337-340
(2004).
17. R. J. Abdel-Jalil, and Wolfgang Voelter, “ Synthesis of New 2-Fuoro-6-(4-substituted-1piperazinyl)-1H-Benzimidazoles
of Potential Biological Interest”. J. Heterocylic Chem., 42, 1-5
(2005).
18. R. J. Abdel-Jalil, M. Khanfar, K. Abu-Safieh, S. Al-Gharabli, M. El-Abadelah and W. Voelter,
“Efficient One-Pot Synthesis of Pyrazolopyrimidines, Intermediates for Potential
Phosphodiesterase Inhibitors”, Monatshefte Chem., 136(4), 619-624 (2005).
19. Z. S. Saify, N. Mushtaq, K. Khan, S. Perveen, S. Tasadaque, R. J. Abdel-Jalil, M. Fecker and W.
Voelter, “ Synthesis and Pharmacological Activity of 4-(4-Chlorophenyl)-4-Hydroxypiperidine
Derivatives”, Chem. Pharm. Bull., 53, 64-66 (2005).
20. K. Khan, S. G. H. Maharvi, S. Perveen, M. T. Khan, S., R. J. Abdel-Jalil, S. Tasadaque, A. Shah,
M. Fecker, M. I. Choudhary, A. Ur-Rahman and W. Voelter,” Synthesis of Methyl Ether
Analogues of Sildenafil (Viagra®) Possessing Tyrosine Inhibitory Potential” Chemistry &
Biodiversity, 2, 470-476 (2005).
21. R. J. Abdel-Jalil, R. Stoll and Wolfgang Voleter, “ Microwave-Assisted Synthesis of 1-Aryl-3acetyl-1,4,5,6-Tetrahydrobenzimidazo
[2,3,d]- [1,2,4]Triazines: The First Example of a Novel
Ring System”, Tetrahedron Letters, 46, 1725 (2005).
22. R. J. Abdel-Jalil, S. T. Shah, K. Khan and W. Voelter, “ Anovel Route Towards the Synthesis of
Stereospecific N-Substituted Chiral Morpholines”, Letters Org. Chem., 2(4), 306-308 (2005).
23. R. J. Abdel-Jalil, S. T. Shah, K. Khan and W. Voelter, “ Stereospecific Synthesis of Chiral
Tetrahydroquinoxaline, 2,3-dihydro-benzo[1,4]dioxin and 2,3-dihydro-naphtho[2,3-b][1,4]-dioxin
Derivatives. ”, Letters Org. Chem., 2(3), 238-241 (2005).
24. R. J. Abdel-Jalil, M. Khanfar, S. Al-Gharabli, M. El-Abadelah and W. Voelter, “High
Throughput Synthesis of Pyrazolopyrimidines via Copper-catalysed Cyclization, and X-Ray
Study”, Heterocycles 65(8), 1821-1827 (2005).
25. R. J. Abdel-Jalil, Hani M. Aldoqum, Mikdad T. Ayoub, and Wolfgang Voelter, “Synthesis and
Antitumor Activity of 2-Aryl-7-fluoro- 6-(4-methyl-1-piperazinyl)-4(3H)-Quinazolinones”,
Heterocycles, 65(9), 2061-2070 (2005).

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26. R. J. Abdel-Jalil, Michael Übele, Walter Ehrlichmann, Wolfgang Voelter and H.-Jürgen
Machulla, "1-[18F]Fluoroethyleneglycol-2-Nitroimidazoles, a New class of Potential Hypoxia
PET Markers", J. Radioanalytical and Nuclear Chemistry, 267, 557-560 (2006).
27. M. Z. Al-Noaimi, R. J. Abdel-Jalil, S. F. Haddad, R. H. Al-Far and R. J. Crutchy, “ Ruthenium(II)
Complex of the Novel Azoimine Ligand, α-acetyl-α-Phenylazochlorophenylazomethane”
Inorganica Chimica Acta, 359, 2395-2399 (2006).
28. M. Z. Al-Noaimi, R. J. Abdel-Jalil, M. El-Abadelah, S. F. Haddad, and W. Voelter, “ Metal-
Assisted Oxidation Cyclization of Arylamidrazones I. Synthesis of 3-Acetyl-1,4-Dihydro-1-
Phenyl-1,2,4-Benzotriazine”. Monatshefte Chem., Monatshefte Chem., 137(6), 745-750 (2006).
29. R. J. Abdel-Jalil, Wolfgang Voelter, Calcia Maichele-Mossmer, Younes Baqi and H.-Jürgen
Machulla, "Crystal Structure of 2-(3-acetyl-1-(4-bromophenyl)-5-[(R)-4-chlorophenyl]-1,2,4triazolo-4-yl)-deoxy-1,3,4,6-tetraacetyl-β-D-glucose”
Z. Kristallogr. NCS, 221 (2006).
30. R. J. Abdel-Jalil, Wolfgang Voelter, Calcia Maichele-Mossmer, Dirk Loefler and H.-Jürgen
Machulla, " Crystal structure of N,N,N-tris[2-(2-nitro-1H-imidazol-1-yl)ethyl]amine’,
Z. Kristallogr. NCS, 223, 505-506 (2008).
31. Khaled H. Abu Elteen, Raid J. Abdel-Jalil, Mawieh A. Hamad, Samer I. Al-Gharabli, Mohamad
Ghaleb, Khalid M. Khan, and Wolfgang Voelter, " Fungicidal Effects of Some Derivatives of 2-
Ferrocenyl Benzimidazoles: A Possible Template for Antifungal Drug Design" , Journal of
Medical Sciences, accepted (2008).
32. R. J. Abdel-Jalil, M. Aqarbeh, D. Loeffler, B. Shen, S. Abo Orabi, W. Voelter and H.-Jürgen
Machulla, " Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-
2-nitroimidazoles as possible hypoxia imaging pharmaceuticals", J. Radioanalytical and Nuclear
Chemistry, 283, 239-243, (2010).
33. R. J. Abdel-Jalil, E. Q. El Momani , M. Hamad, W. Voelter, M. S. Mubarak, B. H. Smith and D.
G. Peters,” Synthesis, antitumor activity, and electrochemical behavior of some piperazinyl
amidrazones”, Monatshefte fuer Chemie, 141, 251-258 (2010).
34. P. Dolashka-Angelova, R. J. Abdel-Jalil, R. A. Al-Qawasme, N. Stambolieva and Wolfgang
Voelter, ” Synthesis and inhibition properties of a series of pyranose derivatives towards a
Zn-metalloproteinase from Saccharomonospora canescens”, Carbohydrate Res.-accepted (2010).
• Patent:
Abdel-Jalil, Raid; Al-Abed, Yousef; El-Abadelah, Mustafa M.; Khanfar, Monther; Sabri, Salim
S.; Voelter, Wolfgang. Pyrazolopyrimidinone Derivatives Conjugated to Thiophene Moieties or
Benzo [fused] 5-membered heterocycles for Erectile Dysfunction. PCT Int. Appl. (2001), 37 pp.
WO 0103644 A2 20010118 AN 2001:50436.
PRESENTATIONS at International Scientific Conferences:
1. Raid J. Abdel-Jalil, Ehab Q. Al-Momani, Lubna Tahtamooni, H.-J. Machulla and Wolfgang
Voelter, “Synthesis and in vitro Antitumor Activity of Some 7-Fluoro-6-(4-methyl-1-piperazinyl)-
2-(thiosubstituted)-4(3H)-quinazolinones”, 9 th International Conference of Heteroatom
Chemistry, Oviedo, Spain, July 2009.
2. Raid J. Abdel-Jalil, Eman mahmoud, and wolfgang Voelter, “Synthesis and antitumor activities
of some 3-(4-substituted-1-piperzinyl)-4-methylbenzo[g]cinnolines”, The Leading European
Event for Drug Discovery (MipTec-2007)U, Basel, Switzerland, 7-10 May, 2007.
3. Raid J. Abdel-Jalil, Hani Aldoqum, Mikdad A. Arif and wolfgang Voelter, “Synthesis and
antitumor activity of 7-fluoro-6-(4-methyl-1-piperazinyl)-2-aryl-4(3H)-quinazolinones”, Sixth
Tetrahedron Symposium, Challenges in Organic Chemistry, Purdue, France 29-1 July, 2005.

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4. Raid J. Abdel-Jalil and Wolfgang Voelter, “A convenient approach to the synthesis of triazols
bearing sugar moieties” 13th European Carbohydrate Symposium, Bratislava, Slovakia, August
21-26, 2005.
5. Raid J. Abdel-Jalil, M. Uebele, W. Ehrlichmann, Wolfgang Voelter, Hans-Jurgen Machulla, “1-
[18F]Fluoroethyleneglycol-2-nitroimidazoles, a novel class of potential hypoxia PET markers”,
International Symposium on Trends in Radiopharmaceuticals (ISTR-2005)”, Vienna, Austria,
14-18 November, 2005.
6. Raid J. Abdel-Jalil, Hans-Jurgen Machulla and Wolfgang Voelter, “A novel and efficient
cyclization access to optically of pure 1,4,5,6-tetrahydro-as-trizines, fused to carbohydrate”, 12th
European Carbohydrate Symposium, Grenoble, France, July 6-11, 2003.
7. T. Toyokuni, J. C. Walsh, R. J. Abdel-Jalil, A. Dominguez, J. E. Shively, N. Satyamurthy, J. R.
Barrio, M. E. Phelps, A. M. Wu, and S. S. Gambhir, “Synthesis of a New Maleimide-Containing
Thiol-Reactive 18F-Labeling Agent, N-{4-[(4-
[18F]Fluorobenzylidene)aminooxy]butyl}maleimide, and its Application to the Labeling of an
Oligodeoxynucleotide. 48th Annual Meeting • Society of Nuclear Medicine, Toronto, Ontario,
Canada, 2001.
8. R. J. Abdel-Jalil, J. C. Walsh, J. L. Stone, J. E. Shively, N. Satyamurthy, J. R. Barrio, M. E.
Phelps, A. M. Wu, S. S. Gambhir, and T. Toyokuni, ” Synthesis of 4-[(4-
[18F]Fluorobenzylidene)aminooxy]butyl Vinyl Sulfone as an Amine- and Thiol-Reactive 18F-
Labeling Agent”, 48th Annual Meeting • Society of Nuclear Medicine, Toronto, Ontario, Canada,
2001.
9. R. J. Abdel-Jalil, Raed Al-qauasmeh, Peter Heeg, Mustafa El-Abadelah, Salim Sabri and
Wolfgang Voelter," Synthesis and Properties of 6-Flouro-7-(1-Methyl-4piperazinyl)quionoxalines",
7th Ibn Sina International Conference on Pure and Applied
Heterocyclic Chemistry, P-148, Alexandria-Egypt. 2000.
10. R. J. Abdel-Jalil, Monther Khanfar, Mustafa El-Abadelah, Salim Sabri, Samer Al-Gharabli and
Wolfgang Voelter, " Facile Synthesis of Pyrazolo[3,4-d]pyramidine-7-one Derivatives", 7th Ibn
Sina International Conference on Pure and Applied Heterocyclic Chemistry, P-147,
Alexandria-Egypt. 2000.
11. R. J. Abdel-Jalil, Wolfgang Voelter, " An expeditious approach to tri-substituted chiral
thiazolines", The 10th European Carbohydrate Symposium, PA 079, Galway, Ireland 1999.
12. R. J. Abdel-Jalil, Wolfgang Voelter, " A stereospecific synthesis of N-substituted chiral
morpholines", The 10th European Carbohydrate Symposium, PA 080, Galway, Ireland
1999.
13. R. J. Abdel-Jalil, R. A. Al-Qawasmeh, W. Voelter, "A Stereospecific Synthesis of Tetra-
Substituted Chiral Piperazines", The 19th International Carbohydrate Symposium, BP020 San
Diego, USA. 1998.
14. R. J. Abdel-Jalil, R. A. Al-Qawasmeh, W. Voelter, "(4→4)-Di(2,3-anhydropentopyranosides), a
Novel Class of Potential Enzyme Inhibitors", The 19th International Carbohydrate
Symposium, BP167 San Diego, USA 1998.
15. R. J. Abdel-Jalil, R. A. Al-Qawasmeh Y. Al-Abed, W. Voelter, The 9th European
Carbohydrate Symposium, A170, Utrecht, Netherlands 1999.
16. R. J. Abdel-Jalil, Y. Al-Abed, R. A. Al-Qawasmeh, W. Voelter, The 9th European
Carbohydrate Symposium, A171, Utrecht, Netherlands 1999.
Date of birth: 1970
Place of Birth: Jordan
Nationality: Jordanian
Status: Married with 5 children
Personal Data