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issn 0923-7534<br />

<strong>Annals</strong> <strong>of</strong><br />

<strong>Oncology</strong><br />

Volume 19 No. 8 August 2008<br />

Original articles: Temsirolimus in metastatic renal cell carcinoma<br />

Cetuximab with FUFOX in untreated patients with<br />

advanced colorectal cancer<br />

QoL and comorbidity as prognostic determinants<br />

in NSCLC<br />

Reviews: Targeting Src in breast cancer<br />

www.annonc.oxfordjournals.org<br />

www.esmo.org<br />

www.jsmo.umin.jp<br />

Submit your manuscript online at<br />

http://annonc.manuscriptcentral.com


<strong>Annals</strong> <strong>of</strong> <strong>Oncology</strong><br />

Official Journal <strong>of</strong> the European Society for Medical <strong>Oncology</strong> and<br />

the Japanese Society <strong>of</strong> Medical <strong>Oncology</strong><br />

editor-in-chief:<br />

D. J. Kerr, <strong>Oxford</strong>, UK<br />

associate editors<br />

M. S. Aapro, Genolier, Switzerland<br />

J. O. Armitage, Omaha, Nebraska, USA<br />

P. Boyle, Lyon, France<br />

K. Fizazi, Villejuif, France<br />

R. Labianca, Bergamo, Italy<br />

H. McLeod, Chapel Hill, North Carolina, USA<br />

L. Påhlman, Uppsala, Sweden<br />

M. Pfreundschuh, Hamburg/Saar, Germany<br />

C. J. A. Punt, Nijmegen, The Netherlands<br />

V. Raina, New Delhi, India<br />

N. Saijo, Tokyo, Japan<br />

N. Thatcher, Manchester, UK<br />

J. B. Vermorken, Edegem, Belgium<br />

D. A. Vorobi<strong>of</strong>, Johannesburg, South Africa<br />

H. Yoshikawa, Tsukuba, Japan<br />

editorial board<br />

K. K. Antman, New York, USA<br />

J-P. Armand, Villejuif, France<br />

J. Baselga, Barcelona, Spain<br />

M. Bendandi, Pamplona, Spain<br />

C. Bokemeyer, Hamburg, Germany<br />

G. Bonadonna, Milan, Italy<br />

F. Cabanillas, Houston, Texas, USA<br />

C. J. Castro, Bogota, Columbia<br />

A. S. Coates, Sydney, Australia<br />

J. M. Connors, Vancouver, Canada<br />

H. Cortés-Funes, Madrid, Spain<br />

D. Cunningham, Sutton, UK<br />

S. Daryanani, Caracas, Venezuela<br />

C. Dittrich, Vienna, Austria<br />

L. H. Einhorn, Indianapolis, Indiana, USA<br />

E. A. Eisenhauer, Kingston, Canada<br />

S. Filipovic, Nisˇ, Serbia<br />

B. Glimelius, Uppsala, Sweden<br />

A. Goldhirsch, Milan, Italy<br />

H. H. Hansen, Copenhagen, Denmark<br />

K. Hatake, Tokyo, Japan<br />

W. Hiddemann, Munich, Germany<br />

D. K. Hossfeld, Hamburg, Germany<br />

A. M. Hughes, Macclesfield, UK<br />

C. Ishioka, Sendai, Japan<br />

P. Jacobs, Cape Town, South Africa<br />

J. A. Jankowski, Leicester, UK<br />

<strong>Annals</strong> <strong>of</strong> <strong>Oncology</strong> is devoted to the rapid circulation <strong>of</strong> scientific communications<br />

concerning oncology, particularly medical oncology. Its character,<br />

however, is multidisciplinary, in reflection <strong>of</strong> the proliferation <strong>of</strong> activities<br />

and interests globally and contributions on clinically oriented laboratory<br />

research, surgery and radiotherapy are assured by the presence <strong>of</strong> representatives<br />

<strong>of</strong> these disciplines on the Editorial Committee and Board.<br />

<strong>Annals</strong> <strong>of</strong> <strong>Oncology</strong> is covered in C.A.B. International, Current Clinical Cancer, Current<br />

Contents/Clinical Medicine®, Current Contents/Life Sciences, Elsevier BIOBASE/Current<br />

Awareness in Biological Sciences, EMBASE/Excerpta Medica, IBIDS, Index Medicus/<br />

MEDLINE, The International Monitor in <strong>Oncology</strong>, Medical Documentation Service,<br />

Science Citation Index® and Science Citation Index Expanded.<br />

editor emeritus<br />

F. Cavalli, Bellinzona, Switzerland<br />

CME editor<br />

R. Midgley, <strong>Oxford</strong>, UK<br />

Y. Kakehi, Kagawa, Japan<br />

N. Katsumata, Tokyo, Japan<br />

S. B. Kaye, Sutton, UK<br />

H. M. Khaled, Cairo, Egypt<br />

C-H. Köhne, Dresden, Germany<br />

P. A. Kosmidis, Athens, Greece<br />

H. Kunitoh, Tokyo, Japan<br />

T. Le Chevalier, London, UK<br />

J. S. Macdonald, New York, USA<br />

F. Mandelli, Rome, Italy<br />

G. Masera, Monza, Italy<br />

P. Mauch, Boston, Masachusetts, USA<br />

R. J. Mayer, Boston, Masachusetts, USA<br />

M. Middleton, <strong>Oxford</strong>, UK<br />

H. Minami, Kobe, Japan<br />

V. M. Moiseyenko, St Petersburg, Russian<br />

Federation<br />

F. M. Muggia, New York, USA<br />

Y. Nagata, Kyoto, Japan<br />

T. Naoe, Nagoya, Japan<br />

T. Ngoma, Dar es Salaam, Tanzania<br />

K. Nishio, Osaka, Japan<br />

K. Öberg, Uppsala, Sweden<br />

A. Ohtsu, Kashiwa, Japan<br />

P. Parikh, Mumbai, India<br />

G. J. Peters, Amsterdam, The Netherlands<br />

M. Piccart, Brussels, Belgium<br />

executive editor: Lewis Rowett<br />

editorial <strong>of</strong>fice: <strong>Annals</strong> <strong>of</strong> <strong>Oncology</strong>, Via Luigi Taddei 4, CH-6962 Viganello-Lugano, Switzerland<br />

H. M. Pinedo, Amsterdam, The Netherlands<br />

M. Ranson, Manchester, UK<br />

R. Rosell, Badalona, Spain<br />

A. Roth, Geneva, Switzerland<br />

P. Rougier, Boulogne, France<br />

E. K. Rowinsky, Branchburg,<br />

New Jersey, USA<br />

M. Saghatchian, Villejuif, France<br />

M. Sasako, Nishinomiya, Japan<br />

W. Scheithauer, Vienna, Austria<br />

H-J. Schmoll, Halle, Germany<br />

H. C. Schouten, Maastricht, The Netherlands<br />

G. Schwartsmann, Porto Alegre, Brazil<br />

K. C. Soo, Singapore<br />

C. N. Sternberg, Rome, Italy<br />

S. Tjulandin, Moscow, Russian Federation<br />

Y. Tokuda, Isehara, Japan<br />

M. Tonato, Perugia, Italy<br />

T. Tursz, Villejuif, France<br />

C. Vallejos Sologuren, Lima Peru<br />

E. Van Cutsem, Leuven, Belgium<br />

A. T. Van Oosterom, Leuven, Belgium<br />

M. Venturini, Genoa, Italy<br />

E. E. Vokes, Chicago, Illinois, USA<br />

J. Zalcberg, Melbourne, Australia


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