pole hospitalier anapath-digestif-oncologie-urologie-endocrinologie

POLE HOSPITALIER
ANAPATH-DIGESTIF-ONCOLOGIE-UROLOGIE-ENDOCRINOLOGIE
CHEF DE PÔLE : Pr Jean-Charles GRIMAUD
ADRESSE : Service de gastroentérologie, CHU Nord, chemin des Bourelys, 13915 Marseille
TELEPHONE : 0491968737
COURRIEL : jean-charles.grimaud@ap-hm.fr
ECOLE DOCTORALE : Sciences de la vie et de la santé
RATTACHEMENTS :
DISCIPLINES D’APPARTENANCES :
SPECIALITÉS : Gastroentérologie ; Chirurgie digestive ; Urologie ; Anatomie Pathologique ;
Endocrinologie
EFFECTIFS
Enseignants-Chercheurs (PU-PH, MCU-PH, CCA, AHU) :
PUPH : 10 ;
MCUPH : 5 ;
CCA : 6 ;
AHU : 2
Personnel Hospitalier (PH, Attaché) : 9
Personnel Technique :
Personnel Administratif :
Etudiants :
PERSONNELS RATTACHÉS A UNE EQUIPE DE RECHERCHE
Garcia Stéphane (PUPH) ; Taranger Charpin Colette (PUPH) ; Giusiano Sophie (MCUPH) ;
Secq Véronique (AHU) : Centre de Recherche en Cancérologie de Marseille INSERM
U1068 "Stress cellulaire" 163 av. de Luminy, Case 915, 13288 Marseille
Grimaud Jean-Charles (PUPH) ; Bouvier Michel (vacataire) ; Vitton Véronique (MCUPH) :
Interface de recherche translationnelle en neurogastroentérologie, CRN2M, UMR 7286,
Aix-Marseille Université, Marseille
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INTITULÉ : Gastroentérologie
RESPONSABLE : Pr Grimaud
DISCIPLINE :
INTITULÉ : Chirurgie digestive
RESPONSABLE : Pr Brunet
DISCIPLINE :
INTITULÉ : Urologie
RESPONSABLE : Pr Rossi
DISCIPLINE :
INTITULÉ : Anatomie Pathologique
RESPONSABLE : Pr Taranger Charpin
DISCIPLINE :
SERVICES HOSPITALIERS
INTITULÉ : Endocrinologie, Maladies métaboliques et Nutrition
RESPONSABLE : Pr Dutour Meyer
DISCIPLINE :
PUBLICATIONS ANNÉES 2011 et 2012
FONTAINE-BISSON B, ALESSI MC, SAUT N, FUMERON F, MARRE M, DUTOUR A, BADENS C,LEVY N,
TICHET J, JUHAN-VAGUE I, TREGOUET DA, BALKAU B, MORANGE PE.Polymorphisms of the lamina
maturation pathway and their association with themetabolic syndrome: the DESIR prospective
study. J Mol Med. 2010; 88: 193-201.
DUTOUR A , ACHARD V, SELL H, NAOUR N, COLLART F, GABORIT B, SILAGHI A, ECKEL J,ALESSI
MC, HENEGAR C, CLEMENT K. Secretory Type II Phospholipase A2 Is Produced andSecreted by
Epicardial Adipose Tissue and Overexpressed in Patients with Coronary ArteryDisease. J Clin
Endocrinol Metab. 2010; 95:963-7.
CUISSET T, FRERE C , POYET R, QUILICI J, GABORIT B, BALI L, BRISSY O, LAMBERT M,MORANGE
PE, ALESSI MC, BONNET JL. Clopidogrel response: Head-to-head comparison ofdifferent platelet
assays to identify clopidogrel non responder patients after coronarystenting. Arch Cardiovasc Dis.
2010; 103:39-45. (0.633)
GABORIT B, CUISSET T, FRERE C, ALESSI MC, DUTOUR A . Glycemic control and
clopidogrelresponse. Am Heart J. 2010; 159:e35. (IF = 4.357)
MEAS T, DEGHMOUN S, CHEVENNE D, GABORIT B, ALESSI MC, LEVY-MARCHAL C PAI-1 is an
independent marker of metabolic disorders in young adults born SGA J ThrombHaemost. 2010 Dec;
8(12):2608-13. doi: 10.1111/j.1538-7836.2010.04037.x.
ACHARD V , TASSISTRO V, BOULLU-CIOCCA S, GRINO M. Expression and nutritionalregulation of
the (pro)renin receptor in rat visceral adipose tissue. J Endocrinol Invest.2011; Apr 6. [Epub ahead
of print]
CUISSET T , QUILICI J, GROSDIDIER C, FOURCADE L, GABORIT B, PANKERT M, MOLINES
L,MORANGE PE, BONNET JL and ALESSI MC. Comparison of Platelet Reactivity and Clopidogrel
Response in Patients 75 Years Undergoing Percutaneous Coronary
Intervention for Non-ST-Segment Elevation Acute Coronary Syndrome. Am JCardiol. 2011 Nov
15;108(10):1411-6
CUISSET T , QUILICI J, COHEN W, FOURCADE L, SAUT N, PANKERT M, GABORIT B, CARRIERIP,
MORANGE PE, BONNET JL and ALESSI MC. Usefulness of High Clopidogrel MaintenanceDose
According to CYP2C19 Genotypes in Clopidogrel Low Responders UndergoingCoronary Stenting for
Non ST Elevation Acute Coronary Syndrome. Am J Cardiol. 2011 Sep15;108(6):760-5
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DUTOUR A , ROLL P, GABORIT B, COURRIER S, ALESSI MC, TREGOUET DA, ANGELIS F,ROBAGLIA-
SCHLUPP A, LESAVRE N, CAU P, LEVY N, BADENS C and MORANGE PE. Highprevalence of
laminopathies among patients with metabolic syndrome. Hum MolGenet.2011;20:3779-86
GABORIT B , KOBER F, JACQUIER A, MORO PJ, CUISSET T, BOULLU S, DADOUN F, ALESSI
MC,MORANGE P, CLEMENT K, BERNARD M and DUTOUR A. Assessment of epicardial fatvolume and
myocardial triglyceride content in severely obese subjects: relationship tometabolic profile, cardiac
function and visceral fat. Int J Obes (Lond). 2011 Jul 5. doi:10.1038/ijo.2011.117
ANGELAKIS E , BASTELICA D, BEN AMARA A, EL FILALI A, DUTOUR A, MEGE JL, ALESSI
MC,RAOULT D. An evaluation of the effects of Lactobacillus ingluviei on body weight, theintestinal
microbiome and metabolism in mice. Microb Pathog. 2011 Oct 18. [Epub ahead
GABORIT B, KOBER F, JACQUIER A, MORO PJ, FLAVIAN A, QUILICI J, CUISSET T,SIMEONI
U,COZZONE P, ALESSI MC, CLEMENT K, BERNARD M, DUTOUR A. Epicardial Fat Volume
IsAssociated With Coronary Microvascular Response in Healthy Subjects: A Pilot Study.Obesity
(Silver Spring).2011 Oct 6.doi: 10.1038/oby.2011.283.[Epub ahead of print]PubMed PMID:
21979392.
Baylot V, Andrieu C, Katsogiannou M, Taieb D, Garcia S, Giusiano S, Acunzo J,Iovanna J, Gleave M,
Garrido C, Rocchi P. OGX-427 inhibits tumor progression andenhances gemcitabine chemotherapy
in pancreatic cancer. Cell Death Dis. 2011 Oct20;2:e221..
Bocoum AI, Daumas A, Cammilleri S, Bernard F, Rossi P, Bagneres D, Demoux AL,Aissi K, Dales JP,
Berdah S, Chaumoitre K, Frances Y, Granel B. [Recurrentpericarditis revealing a
systemicsarcoidosis]. Rev Med Interne. 2011Sep;32(9):575-9.
Seux M, Peuget S, Montero MP, Siret C, Rigot V, Clerc P, Gigoux V, PellegrinoE, Pouyet L,
N'Guessan P, Garcia S, Dufresne M, Iovanna JL, Carrier A, André F,Dusetti NJ. TP53INP1 decreases
pancreatic cancer cell migration by regulatingSPARC expression. Oncogene. 2011 Jul
7;30(27):3049-61.
Giusiano S, Cochet C, Filhol O, Duchemin-Pelletier E, Secq V, Bonnier P,Carcopino X, Boubli L,
Birnbaum D, Garcia S, Iovanna J, Charpin C. Protein kinaseCK2α subunit over-expression
correlates with metastatic risk in breastcarcinomas: quantitative immunohistochemistry in tissue
microarrays. Eur JCancer. 2011 Mar;47(5):792-801.
Monchal T, Barbier L, Hornez E, Marciano S, Dales JP, Berdah S, Moutardier V.Ruptured liver cell
adenoma in man: great fortune in misfortune. Acta Chir Belg.2010 Sep-Oct;110(5):555-7.
Giusiano S, Secq V, Carcopino X, Carpentier S, Andrac L, Lavaut MN, AllasiaC, Bonnier P, Iovanna
JL, Garcia S, Boubli L, Birnbaum D, Charpin C.Immunohistochemical profiling of node negative
breast carcinomas allowsprediction of metastatic risk. Int J Oncol. 2010 Apr;36(4):889-98.
Taïeb D, Giusiano S, Sebag F, Marcy M, de Micco C, Palazzo FF, Dusetti NJ,Iovanna JL, Henry JF,
Garcia S, Taranger-Charpin C. Tumor protein p53-inducednuclear protein (TP53INP1) expression in
medullary thyroid carcinoma: a molecularguide to the optimal extent of surgery? World J Surg.
2010 Apr;34(4):830-5.
Rozet F, Hennequin C, Fromont G, Mongiat-Artus P, Bastide C, Beuzeboc P,Cormier L, Eiss D,
Peyromaure M, Richaud P, Salomon L, Soulié M. [High-riskprostate cancer. Review by the Oncology
Committee of the French UrologyAssociation]. Prog Urol. 2011 Dec;21(13):901-8. doi:
10.1016/j.purol.2011.09.006.
Clément C, Rossi P, Aissi K, Barthelemy P, Guibert N, Auquier P, Ragni E,Rossi D, Frances Y,
Bastide C. Incidence, risk profile and morphological pattern of lower extremity venous
thromboembolism after urological cancer surgery. J Urol. 2011 Dec;186(6):2293-7. doi:
10.1016/j.juro.2011.07.074. Epub 2011 Oct 20.
Bastide C, Rossi D, Lechevallier E, Bladou F, Barriol D, Bretheau D, Grisoni V, Mancini J, Giusiano
S, Eghazarian C, Van Hove A. Seminal vesicle invasion:what is the best adjuvant treatment after
radical prostatectomy? BJU Int. 2012Feb;109(4):525-30; discussion 531-2.
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Rouprêt M, Drouin SJ, Larré S, Neuzillet Y, Botto H, Hitier M, Rigaud J, Crew J, Xylinas E, Salomon
L, Cornu JN, Iborra F, Champetier D, Rozet F, Flamand V,Bastide C, Cormier L, Durand X, Lunardi
P, Rischmann P, Nouhaud FX, Ferlicot S,Patard JJ, Floch AP, Irani J, Peyronnet B, Bensalah K,
Poissonnier L, Grès P,Droupy S, Casenave J, Wallerand H, Soulié M, Pfister C; Bladder Cancer
Committee of the French National Association of Urology (“CC-AFU Vessie”). Oncologicoutcomes
and survival in pT0 tumors after radical cystectomy in patients without neoadjuvant chemotherapy:
results from a large multicentre collaborative study.Ann Surg Oncol. 2011 Dec;18(13):3833-8.
Giusiano S, Garcia S, Andrieu C, Dusetti NJ, Bastide C, Gleave M,Taranger-Charpin C, Iovanna JL,
Rocchi P. TP53INP1 overexpression in prostatecancer correlates with poor prognostic factors and is
predictive of biologicalcancer relapse. Prostate. 2012 Feb 1;72(2):117-28.
Pignot G, Irani J, Bastide C, Ravery V. [New concepts in management of NMIBCin 2010]. Prog Urol.
2011 Mar;21 Suppl 2:S34-7.
Lopater J, Hartung O, Bretelle F, Bastide C. Management of angiomyolipoma venacava thrombus
during pregnancy. Obstet Gynecol. 2011 Feb;117(2 Pt 2):440-3.
Arroua F, Maurin C, Carcenac A, Ragni E, Rossi D, Bastide C. [Role of surgery (cytoreductive
nephrectomy and metastasectomy) in the management of metastaticrenal cell carcinoma: a
literature review]. Prog Urol. 2010 Dec;20(13):1175-83.Salomon L, Azria D, Bastide C, Beuzeboc
P, Cormier L, Cornud F, Eiss D,Eschwège P, Gaschignard N, Hennequin C, Molinié V, Mongiat Artus
P, Moreau JL,Péneau M, Peyromaure M, Ravery V, Rebillard X, Richaud P, Rischmann P, Rozet
F,Staerman F, Villers A, Soulié M; Oncology Committee of the French Association of Urology
(CCAFU). [Recommendations Onco-Urology 2010: Prostate cancer]. Prog Urol.2010 Nov;20 Suppl
4:S217-51.
Bastide C, Rozet F, Salomon L, Mongiat-Artus P, Beuzeboc P, Cormier L, EissD, Gaschignard N,
Peyromaure M, Richaud P, Soulié M; Membres du CCAFU. [Criticanalysis of a comparative metaanalysis
on the morbidity, functional andcarcinologic results after radical prostatectomy according
to surgical approach. Work of cancerology committee of the French urological association]. Prog
Urol.2010 Sep;20(8):547-52.
Cazalas G, Mattei S, Birnbaum DJ, Wikberg-Lafont E, Bastide C,Marciano-Chagnaud S, Moutardier
V, Chaumoitre K. [Splenogonadal fusion in anadult with intra-abdominal cryptorchidism]. J Radiol.
2010 Jun;91(6):726-8.French.
Arroua F, Carcenac A, Toledano H, Varoquaux A, Ragni E, Rossi D, Bastide C.Renal artery
pseudoaneurysm following partial nephrectomy: a case report with a current literature review].
Prog Urol. 2010 Jun;20(6):472-5.
Salomon L, Peyromaure M, Mongiat-Artus P, Roset F, Gachignard N, Bastide C,Richaud P, Beuzeboc
P, Cornud F, Molinié V, Soulié M, Benchikh El Fegoun A; lesmembres du CC-AFU. [What's new in
2009 in prostate cancer: highlights from ASTRO,EAU, ASCO and AUA meetings]. Prog Urol. 2010
Mar;20 Suppl 1:S61-7.
Bastide C, Droupy S, Ravaud A, Depuydt-Baillon MG, Guillotreau J. [Managementof muscle invasive
bladder in elderly]. Prog Urol. 2010 Mar;20 Suppl 1:S57-60.
Bastide C, Savage C, Cronin A, Zelefsky MJ, Eastham JA, Touijer K, ScardinoPT, Guillonneau BD.
Location and number of positive surgical margins asprognostic factors of biochemical recurrence
after salvage radiation therapyafter radical prostatectomy. BJU Int. 2010 Nov;106(10):1454-7.
Carcenac A, Arroua F, Gaudart J, Ragni E, Rossi D, Bastide C. [Carcinologicoutcomes after radical
prostatectomy in 81 high-risk patients]. Prog Urol. 2010May;20(5):356-63.
Coulomb MA, Bagnères D, Rossi D, Bastide C. [Epididymitis: Unusualpresentation of periarteritis
nodosa]. Prog Urol. 2010 Apr;20(4):311-3. Goudet P, Murat A, Binquet C, Barthet M, Woehl-
Kremer B. Risk factor and causes of death in MEN type I disease : a GTE cohort among 758
patients. World J Surg 2010;34: 249-55
Coquet-Reinier B, Berdah SV, Grimaud JC, Birnbaum D, Cougard PA, Barthet M, Desjeux A,
Moutardier V, Brunet C. Preoperative Infliximab treatment and post-operative complications after
laparoscopic restorative coloproctectomy after ileal pouch-anal anastomosis : a case-matched
study. Surg Endosc 2010; 24:1866-71
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Ah-Soune Ph, Menard C, Desjeux A, Grimaud JC, Barthet M. Large endoscopic mucosal resection
for colorectal tumors exceeding 4 cm. World J Gastroenterol 2010; 16:588-95
Cougard PA, Desjeux A, Ezzedine S, Berdah S, Barthet M, Grimaud JC. Healing of enterocutaneous
fistulae due to Crohn’s disease with anti TNF alpha antibodies. Inflamm Bowel Dis 2010; 16: 1632-
3
Ezzedine S, Bege Th, Berdah S, Vitton V, Grimaud JC, Barthet M. Endoscopic management of
colonic perforation owing to antiangiogenesis inhibitors. Surg Laparosc Endosc Percutan Tech 2010;
20 : e230-2
Ah Soune Ph, Vitton V, Gonzalez JM, Ezedine S, Bege Th, Berdah S, Grimaud JC, Barthet M.
Transjejunal endoscopic management of abdominal abscesses following total gastrectomy. Dig
Endosc 2011; 103: 1443-1661
Tuvignon N, Liguory C, Ponchon T, Medun B, Fritsch J, Sahel J, Boyer J, Legoux JL, Escourrou J,
Boustiere C, Arpurt JP, Barthet M, Tuvignon P, Bommelaer G, Ducot B, Prat F. Long-term follow-up
after biliary stent placement for post-cholecystectomy bile duct strictures : a multicenter study.
Endoscopy 2011;43:208-16
Surace M, Mercky P, Demarquay JF, Gonzalez JM, Dumas R, Ah Soune Ph, Vitton V, Grimaud JC,
Barthet M. Endoscopic management of digestive fistula with the OTSC system (Over the scope
clip). Gastrointest Endosc 2011; 74:1416-19
Grimaud JC, Munoz-Bongrand N, Siproudhis L, Abramowitz L, Sénéjoux A, Vitton V, Gambiez L, Flourié
B, Hébuterne X, Louis E, Coffin B, De Parades V, Savoye G, Soulé JC, Bouhnik Y, Colombel JF, Contou
JF, François Y, Mary JY, Lémann M and the Groupe d’Etude Thérapeutique des Affections
Inflammatoires du Tube Digestif (GETAID). Fibrin glue for perianal fistulas in Crohn’s disease: an open
label randomized controlled trial. Gastroenterology 2010; 138: 2275-2281
Vitton V, Damon H, Roman S, Mion F. Transcutaneous electrical posterior tibial nerve stimulation for
faecal incontinence: effects on symptoms and quality of life. International Journal of Colorectal
Diseases 2010; 25: 1017-20
Bège T, Emungania O, Vitton V, Ah-Soune P, Nocca D, Noël P, Bradjanian S, Berdah SV, Brunet C,
Grimaud JC, Barthet M. An endoscopic strategy for management of anastomotic complications from
bariatric surgery: a prospective study. Gastrointestinal Endoscopy 2011; 73: 238-44
Vitton V, Baumstarck-Barrau K, Brardjanian S, Caballe I, Bouvier M, Grimaud JC. Impact of High-Level
Sport practice on anal incontinence in a healthy young female population. Journal of Women’s Health
2011; 20: 757-63.
Vitton V, Vignally P, Barthet M, Cohen V, Durieux O, Bouvier M, Grimaud JC. Dynamic Anal
Endosonography and Magnetic Resonance Imaging Defecography in Pelvic Floor Disorders: A
comparison study with defecography. Diseases of the Colon and Rectum 2011; 54: 1368-404.Ezzedine
S, Bege T, Berdah S, Vitton V, Grimaud JC, Barthet M. Endoscopic management of colonic perforation
owing to angiogenesis inhibitors. Surgical Laparoscopy Endoscopy & Percutaneous Techniques 2010;
20: e230-2
Gourcerol G, Vitton V, Leroi AM, Michot F, Abysique A, Bouvier M. How sacral nerve stimulation
works in patients with faecal incontinence. Colorectal Disease 2011
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CONTRATS ANNÉES 2011 et 2012
PR DUTOUR- DR BOULLU- DR DARMON (ARS 2011)
Précarité- Mise en place et évaluation d’une action d’éducation participative visant à influencer
favorablement les pratiques d’approvisionnement alimentaire de populations précaires
Dr DARMON (PHRC régional 2011)
Statuts en micronutriments lipophiles et diabète gestationnel
Dr ATLAN (PHRC national 2011)
Diabète gestationnel étude glyburide versus insuline
PHRC national multicentrique sur le curage radioguidé dans le cancer de la prostate (Pr Bastide,
Année d’obtention 2011, démarrage fin 2012)
Anastomose gastrojéjunale par NOTES : étude expérimentale
Barthet M, CERC ; Bourse de recherche SNFGE 2010 18000 euros
Traitement des fistules de la chirurgie bariatrique par clips OVESCO
AORC APHM Décembre 2010
ENDOLUMENAL GASTROENTERIC ANASTOMOSIS: A MAJOR ADVANCEMENT TOWARDS MINIMALLY
INVASIVE PROCEDURES FOR IMPROVING PATIENT CARE
ESGE Research grant 2012; 10 000 euros Amsterdam 2012
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