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<strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong><br />

<strong>Clinical</strong> <strong>and</strong> <strong>Research</strong> <strong>Seminar</strong><br />

<strong>UCLA</strong> Department of<br />

Ophthalmology Association<br />

Meeting<br />

May 18-19, 2007<br />

RPB Auditorium,<br />

<strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong><br />

38th <strong>Jules</strong> <strong>Stein</strong> Lecturer<br />

David L. Guyton, MD<br />

Zanvyl Krieger Professor of<br />

Pediatric Ophthalmology<br />

The Johns Hopkins University<br />

School of Medicine<br />

5th Bradley R. Straatsma<br />

Lecturer<br />

Robert E. Marc, PhD<br />

Mary H. Boesche Professor of<br />

Ophthalmology<br />

University of Utah School of<br />

Medicine<br />

5th Thomas H. Pettit<br />

Lecturer<br />

Edward E. Manche, MD<br />

Associate Professor of<br />

Ophthalmology<br />

Stanford University School of<br />

Medicine


Join us to revisit the <strong>Institute</strong>, renew acquaintances with<br />

colleagues, <strong>and</strong> learn about research being performed by<br />

Residents, Fellows, <strong>and</strong> Full-Time <strong>and</strong> <strong>Clinical</strong> Faculty<br />

MEETING HIGHLIGHTS<br />

38th <strong>Jules</strong> <strong>Stein</strong> Lecturer<br />

David L. Guyton, MD<br />

Zanvyl Krieger Professor of Pediatric Ophthalmology<br />

The Johns Hopkins University School of Medicine<br />

5th Bradley R. Straatsma Lecturer<br />

Robert E. Marc, PhD<br />

Mary H. Boesche Professor of Ophthalmology<br />

University of Utah School of Medicine<br />

5th Thomas H. Pettit Lecturer<br />

Edward E. Manche, MD<br />

Associate Professor of Ophthalmology<br />

Stanford University School of Medicine<br />

S. RODMAN IRVINE PRIZE<br />

Presented to a full-time or clinical faculty member who has demonstrated<br />

excellence in professional actions <strong>and</strong> exemplary dedication to teaching<br />

future generations of ophthalmologists.<br />

2007 Recipient announced on May 19<br />

2006 Howard Krauss, MD<br />

2005 Dean Bok, PhD amd Leonard Apt, MD<br />

2004 Award not presented<br />

2003 George B. Primbs, MD<br />

2002 Richard El<strong>and</strong>er, MD<br />

2001 Robert Y. Foos, MD, PhD<br />

2000 Roger W. Sorenson, MD<br />

1999 Edwin P. Hill, MD<br />

1998 Robert S. Hepler, MD<br />

1997 Norman E. Byer, MD <strong>and</strong> Allan E. Kreiger, MD<br />

1996 Donald E. Dickerson, MD<br />

1995 Bradley R. Straatsma, MD<br />

1994 David D. Michaels, MD<br />

1993 Henry I. Baylis, MD<br />

1992 Robert E. Christensen, MD<br />

1991 Robert E. Bartlett, MD <strong>and</strong> Irvin S. Pilger, MD<br />

1990 Thomas H. Pettit, MD


SENIOR HONOR AWARD<br />

Presented by the <strong>UCLA</strong> Department of Ophthalmology to senior faculty<br />

members who have provided outst<strong>and</strong>ing service to the Department for<br />

over 25 Years.<br />

2007 Senior Honor Award Recipients<br />

William P. Chen, MD, FACS<br />

Teresa O. Rosales, MD<br />

JULES STEIN EYE INSTITUTE CLINICAL AND<br />

RESEARCH SEMINAR MEETING COORDINATORS<br />

Anthony C. Arnold, MD, Chair<br />

Robert Alan Goldberg, MD<br />

Gary N. Holl<strong>and</strong>, MD<br />

Bartly J. Mondino, MD<br />

Xianjie Yang, PhD<br />

Department of Ophthalmology - <strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong><br />

Chairman <strong>and</strong> Director, Bartly J. Mondino, MD<br />

<strong>UCLA</strong> Department of Ophthalmology Association<br />

President, Kathryn M. Gardner, MD<br />

<strong>UCLA</strong> Department of Ophthalmology Residency Program<br />

Director, Anthony C. Arnold, MD<br />

COURSE DESCRIPTION:<br />

The <strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong> <strong>Clinical</strong> <strong>and</strong> <strong>Research</strong> <strong>Seminar</strong> will provide ophthalmologists<br />

<strong>and</strong> vision scientists with the opportunity to discuss <strong>and</strong> share<br />

experiences, review relevant literature, <strong>and</strong> synthesize this information into a<br />

comprehensive approach to evaluation, management, <strong>and</strong> treatment of ophthalmic<br />

diseases. In addition to formal lectures there will be ample opportunity<br />

for questions <strong>and</strong> answers <strong>and</strong> discussion between faculty <strong>and</strong> attendees.<br />

GOALS & OBJECTIVES:<br />

At the conclusion of this seminar, the participants should be able to:<br />

• Discuss the future of ophthalmic disorder diagnosis <strong>and</strong> treatment, as well as<br />

outcomes<br />

• Apply the information provided on new surgical techniques <strong>and</strong> contemporary<br />

treatment of ophthalmic disorders to clinical practice<br />

• Explain indications <strong>and</strong> st<strong>and</strong>ards in the medical <strong>and</strong> surgical management of<br />

ophthalmic diseases<br />

• Describe current research being conducted at the <strong>Institute</strong>


PROGRAM<br />

FRIDAY, MAY 18, 2007<br />

8:00am Welcome<br />

Bartly J. Mondino, MD<br />

Orbital <strong>and</strong> Ophthalmic PLASTIC Surgery<br />

Moderator: Robert Alan Goldberg, MD<br />

8:10-8:30am Endonasal Lacrimal Surgery: State of the Art <strong>and</strong> Future Directions<br />

Angelo Tsirbas, MD <strong>and</strong> Robert Alan Goldberg, MD<br />

8:30-8:50am Practical Tricks for Managing Lower <strong>Eye</strong>lid Retraction<br />

Raymond Douglas, MD, PhD<br />

8:50-9:20am The Buccal Fat Pad as a Source of Vascularized Volume in<br />

Midface Reconstruction<br />

Tanuj Nakra, MD; Ronald Mancini, MD; <strong>and</strong> Norman Shorr, MD<br />

9:20-9:40am Orbital Apex Tumors: Outcome of Surgical Management at the<br />

<strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong><br />

Milind Naik, MD<br />

9:40-10:00am Computerized Imaging in <strong>Eye</strong>lid Analysis: How Does Facial<br />

Asymmetry Affect <strong>Eye</strong>lid Position?<br />

Stanley M. Saulny, MD; Shweta Sood, BS; <strong>and</strong> Tanuj Nakra, MD<br />

10:00-10:20am BREAK<br />

CORNEA/UVEITIS<br />

Moderator: Gary N. Holl<strong>and</strong>, MD<br />

10:20-10:35am KIR Genes <strong>and</strong> Inflammatory <strong>Eye</strong> Disease<br />

Ralph D. Levinson, MD<br />

10:35-10:45am Risk Factors for Ocular Involvement in Patients with Recent<br />

Toxoplasma gondii Infection<br />

Hajir Dadgostar, MD, PhD<br />

10:45-11:00am Posterior Polymorphous Corneal Dystrophy is Associated with<br />

TCF8 Gene Mutations <strong>and</strong> Extraocular Developmental<br />

Abnormalities<br />

Anthony J. Aldave, MD<br />

11:00-11:10am Late Virus-Associated Dendriform Keratitis in Patients with a<br />

History of Herpes Zoster Ophthalmicus<br />

Allen Y.H. Hu, MD<br />

11:10-11:25am Modeling Oxygen Flux to the Cornea (Dip CL)<br />

Barry A. Weissman, OD, PhD, FAAO<br />

11:25-11:40am Corneal Biomechanics<br />

D. Rex Hamilton, MD, MS<br />

11:40-11:50am Introduction of Dr. Edward Manche,<br />

The 5th Thomas H. Pettit Lecturer<br />

Gary N. Holl<strong>and</strong>, MD<br />

11:50-12:20pm The 5th Annual Thomas H. Pettit Lecture<br />

Corneal <strong>and</strong> Refractive Surgery Using the Femtosecond Laser<br />

Edward E. Manche, MD<br />

12:20-1:15pm LUNCH


FRIDAY, MAY 18, 2007 continued<br />

BASIC SCIENCE/RETINA<br />

Moderator: Steven D. Schwartz, MD<br />

1:15-1:30pm Cancer, Cataract <strong>and</strong> AMD – The Crystallin Connection<br />

Suraj P. Bhat, PhD<br />

1:30-1:45pm Update on the Genetics of Age-Related Maculopathy<br />

Michael Gorin, MD, PhD<br />

1:45-2:00pm Mutations in SP4 <strong>and</strong> GNB1, Two Genes Causing Retinal<br />

Degeneration in Mice, May be Associated with Digenic Retinitis<br />

Pigmentosa<br />

Debora A. Farber, PhD, DPhhc<br />

2:00-2:15pm Robotic Vitreoretinal Surgery<br />

J.P. Hubschman, MD<br />

2:15-2:30pm A Membrane Receptor for Retinol Binding Protein Mediates<br />

Cellular Uptake of Vitamin A<br />

Hui Sun, PhD<br />

2:30-2:45pm Technology Update: Evaluation <strong>and</strong> Management of Retinal<br />

Diseases<br />

Steven D. Schwartz, MD<br />

2:45-3:00pm Molecular Mechanisms in Activation of Transducin<br />

Wayne L. Hubbell, PhD<br />

3:00-3:15pm BREAK<br />

PEDIATRIC OPHTHALMOLOGY<br />

Moderator: Arthur L. Rosenbaum, MD<br />

3:15-3:30pm The Dragged-Fovea Diplopia Syndrome<br />

David L. Guyton, MD<br />

3:30-3:45pm The Long Term Ocular Alignment Following Adjustable Suture<br />

Strabismus Surgery<br />

Sherwin J. Isenberg, MD<br />

3:45-4:00pm The Torsional Vestibulo-Ocular Reflex<br />

Joseph L. Demer, MD, PhD<br />

4:00-4:15pm Superior Oblique Anterior Tenectomy for Incyclotorsion<br />

Federico G. Velez, MD<br />

4:15-4:30pm Surgical Management of Strabismus Secondary to Glaucoma<br />

Drainage Devices<br />

Noa Ela-Dalman, MD<br />

4:30-4:45pm Acquired Restrictive Infantile Esotropia: A New <strong>Clinical</strong> Entity<br />

Arthur L. Rosenbaum, MD<br />

4:45-4:55pm Introduction of Dr. David Guyton,<br />

The 38th <strong>Jules</strong> <strong>Stein</strong> Lecturer<br />

Arthur L. Rosenbaum, MD<br />

4:55-5:25pm The 38th Annual <strong>Jules</strong> <strong>Stein</strong> Lecture<br />

Changes in Strabismus Over Time: Why <strong>and</strong> How<br />

David L. Guyton, MD<br />

5:25pm Cocktail reception on the <strong>Jules</strong> <strong>Stein</strong> Terrace


SATURDAY, MAY 19, 2007<br />

COMPREHENSIVE OPHTHALMOLOGY<br />

Moderator: Kevin M. Miller, MD<br />

8:00-8:15am Practical Pearls for Presbyopia IOLs<br />

Uday Devgan, MD<br />

8:15-8:30am Scintillating Scotoma without Headache<br />

Ralph D. Levinson, MD<br />

8:30-8:45am Medical Product Development: Prototype to Process to Patent to<br />

Product<br />

Barry S. Seibel, MD<br />

8:45-9:00am <strong>Clinical</strong> Performance of the Lenstec Tetraflex Accommodating<br />

Intraocular Lens<br />

Paul J. Dougherty, MD<br />

9:00-9:15am Outcomes of Cataract Surgery in Monocular Patients<br />

Kevin M. Miller, MD<br />

9:15-9:30am Surgical Correction of Horizontal Nystagmus<br />

Robert M. Sinskey, MD<br />

9:30-9:45am Questions <strong>and</strong> Answers<br />

NEURO-OPHTHALMOLOGY<br />

Moderator: Anthony C. Arnold, MD<br />

9:45-10:00am Optic Neuritis: Update<br />

Lynn K. Gordon, MD, PhD<br />

10:00-10:15am Congruity in Visual Field Defects: Does it Localize the Lesion?<br />

Anthony C. Arnold, MD<br />

10:15-10:30 Business Meeting<br />

10:30-10:45am BREAK<br />

RETINA/BASIC SCIENCE<br />

Moderator: Anurag Gupta, MD<br />

10:45-11:00am Molecular <strong>and</strong> Cellular Changes Induced by CNTF in a Mouse<br />

Model of Retinitis Pigmentosa<br />

XianJie Yang, PhD<br />

1:00-11:15am Targeted LRAT Gene Disruption in the Retinal Pigment Epithelium<br />

Dean Bok, PhD<br />

11:15-11:30am Pharmaco Therapies for Retinal Disease<br />

Anurag Gupta, MD<br />

RESEARCH AWARD RECIPIENTS<br />

11:30-11:40am LABORATORY RESEARCH BY A RESIDENT<br />

11:40-11:50am CLINICAL RESEARCH BY A FELLOW<br />

11:50-12:00am LABORATORY RESEARCH BY A FELLOW<br />

12:00-12:10pm Introduction of Dr. Robert Marc,<br />

The 5th Bradley R. Straatsma Lecturer<br />

Dean Bok, PhD<br />

12:10-12:40pm The 5th Bradley R. Straatsma Lecture<br />

Retinal Remodeling<br />

Robert E. Marc, PhD<br />

12:40-12:50pm Presentation of Awards<br />

12:50-1:45pm LUNCH


SATURDAY, MAY 19, 2007 continued<br />

BASIC SCIENCE/RETINA<br />

Moderator: XianJie Yang, PhD<br />

1:45-2:00pm Tears of the Retinal Pigment Epithelium: an Old Problem in a<br />

New Era<br />

David Sarraf, MD<br />

2:00-2:15pm DGAT1: A New PHAT Enzyme in the <strong>Eye</strong><br />

Joanna Kaylor, PhD<br />

2:15-2:30pm Ocular Oncology<br />

Tara A. Young, MD<br />

2:30-2:45pm BREAK<br />

GLAUCOMA<br />

Moderator: Joseph Caprioli, MD<br />

2:45-2:55pm Mechanisms of Retinal Ganglion Cell Death in Glaucoma<br />

Natik I. Piri, PhD<br />

2:55-3:05pm Calorie Deprivation <strong>and</strong> Glaucoma<br />

Jacky M.K. Kwong, PhD<br />

3:05-3:15pm Glaucoma Surgery in Anticoagulated Patients<br />

Simon K. Law, MD, PharmD<br />

3:15-3:25pm Aqueous Drainage Devices in Patients with Corneal Grafts<br />

JoAnn Giaconi, MD<br />

3:25-3:35pm Glaucoma Risk <strong>and</strong> Antioxidants Among Older Women<br />

Anne L. Coleman, MD, PhD<br />

3:35-3:45pm Alternative Medicine <strong>and</strong> Glaucoma<br />

Duc H. Tran, MD<br />

3:45-3:55pm Concordance of Visual Field Progression in Fellow <strong>Eye</strong>s of<br />

Glaucoma Patients<br />

Jane V. Loman, MD<br />

3:55-4:05pm Long-Term Outcomes of Aqueous Drainage Devices in Primary<br />

Open-Angle Glaucoma<br />

Carlos Souza, MD<br />

4:05-4:15pm <strong>Eye</strong> Disease in Art<br />

Joseph Caprioli, MD<br />

4:15-4:45pm Discussion <strong>and</strong> Case Presentation<br />

4:45pm Adjourn


GENERAL INFORMATION<br />

ACCOMMODATIONS<br />

HILGARD HOUSE<br />

927 Hilgard Avenue,<br />

Los Angeles, California, 90024<br />

<strong>UCLA</strong> rate: $124 per night plus taxes, within<br />

walking distance<br />

Reservations: 310-208-3945<br />

HOTEL ANGELENO<br />

170 N. Church Lane<br />

Los Angeles, California, 90049<br />

<strong>UCLA</strong> rate: $169 per night plus taxes <strong>and</strong><br />

complimentary shuttle to JSEI<br />

Reservations: 310-476-6411<br />

W LOS ANGELES - WESTWOOD HOTEL<br />

930 Hilgard Avenue<br />

Los Angeles, California, 90024<br />

Reservations: 1-800-877-W-HOTELS<br />

WESTWOOD ON WILSHIRE HOTEL<br />

10740 Wilshire Blvd.<br />

Los Angeles, California 90024<br />

<strong>UCLA</strong> rate: $149 per night plus taxes <strong>and</strong><br />

complimentary shuttle to JSEI<br />

Reservations: 310-475-8711<br />

<strong>UCLA</strong> TIVERTON HOUSE<br />

900 Tiverton Avenue<br />

Los Angeles, CA 90024<br />

<strong>UCLA</strong> rate: $120 per night, taxes included,<br />

within walking distance<br />

Reservations: 310-794-0151<br />

DIRECTIONS<br />

Conveniently located within <strong>UCLA</strong> at the corner<br />

of Westwood Boulevard <strong>and</strong> Le Conte<br />

Avenue, the <strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong>, 100 <strong>Stein</strong><br />

Plaza, Los Angeles, 90095 is easily accessible<br />

from all points in Southern California.It is<br />

approximately 15 miles from the Los Angeles<br />

International Airport.Parking is available at the<br />

<strong>Institute</strong> for $8 per day.<br />

From the San Diego Freeway (405)<br />

Take Wilshire Boulevard offramp east (toward<br />

Westwood Boulevard).Turn left onto Westwood<br />

Boulevard from Wilshire.After crossing Le<br />

Conte, turn right onto <strong>Stein</strong> Plaza.Parking is<br />

located immediately to the right (adjacent to<br />

the Doris <strong>Stein</strong> <strong>Eye</strong> <strong>Research</strong> Center) as you<br />

turn onto <strong>Stein</strong> Plaza.<br />

AIRPORT SHUTTLE SERVICE<br />

Prime Time (800) 262-7433<br />

Skycar (310) 306-3554<br />

Super Shuttle (310) 532-5999<br />

TAXICABS<br />

Beverly Hills Cab Co. (310) 273-6611<br />

Checker Cab Co. (800) 300-5007<br />

United Independent (310) 278-2500<br />

Yellow Cab (310) 838-2121<br />

INFORMATION<br />

Debbie Sato<br />

Academic Programs<br />

100 <strong>Stein</strong> Plaza, Rm 3-223<br />

Los Angeles, CA90095-7000<br />

Telephone (310) 825-4617<br />

Fax (310) 206-8015<br />

E-Mail sato@jsei.ucla.edu<br />

ACCREDITATION<br />

The Office of Continuing Medical Education,<br />

David Geffen School of Medicine at <strong>UCLA</strong>, is<br />

accredited by the Accreditation Council for<br />

Continuing Medical Education to provide continuing<br />

medical education for physicians.<br />

The Office of Continuing Medical Education,<br />

David Geffen School of Medicine at <strong>UCLA</strong>,<br />

designates this continuing medical education<br />

activity for a maximum of 14.25 AMA PRA<br />

Category 1 CreditsTM . Physicians should only<br />

claim credit commensurate with the extent of<br />

their participation in the activity.<br />

<strong>UCLA</strong> CONFLICT OF INTEREST DISCLOSURE<br />

The FDA has issued a concept paper which<br />

classifies commercial support of scientific <strong>and</strong><br />

educational programs as promotional unless it<br />

can be affirmed that the program is “truly independent”<br />

<strong>and</strong> free of commercial influence. In<br />

addition to independence, the FDA requires<br />

that non-promotional, commercially supported<br />

education be objective, balanced, <strong>and</strong> scientifically<br />

rigorous. The policy further states that all<br />

potential conflicts of interest of the CME staff<br />

<strong>and</strong> faculty be fully disclosed to the program’s<br />

participants. We, at <strong>UCLA</strong>, fully endorse the<br />

letter <strong>and</strong> spirit of this concept.<br />

In compliance with this policy, the program<br />

audience will have disclosed to them any<br />

potential conflict(s) of interest related to the<br />

contents of presentations made by all faculty<br />

participating in sponsored or jointly sponsored<br />

programs by the <strong>UCLA</strong> School of Medicine.


REGISTRATION<br />

<strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong> <strong>Clinical</strong> <strong>and</strong> <strong>Research</strong> <strong>Seminar</strong><br />

May 18-19, 2007<br />

Name Degree<br />

Address<br />

City State Zip<br />

Telephone Fax<br />

E-Mail<br />

Registration Fee: $375.00<br />

Registration fee includes instructional materials, continental breakfasts, lunches, breaks,<br />

<strong>and</strong> cocktail reception<br />

50% discount for Ophthalmology Residents <strong>and</strong> Fellows who submit letter of verification<br />

from the training program along with registration form.<br />

Please make checks payable to UC Regents or pay by credit card (complete form below)<br />

____ MasterCard ____ Visa ____ American Express<br />

Card Holders Name<br />

Card Number<br />

Expiration Date<br />

Signature<br />

Cancellation Policy: request for refunds must be received in writing no later than May 4,<br />

2007. A h<strong>and</strong>ling fee of $75 will be deducted from each cancelled registration.<br />

Submit registration to:<br />

Academic Programs<br />

100 <strong>Stein</strong> Plaza, Room 3-223<br />

Los Angeles, CA 90095<br />

Telephone: (310) 825-4617<br />

Fax: (310) 206-8015


First Class Mial<br />

U.S. Postage<br />

PAID<br />

<strong>UCLA</strong><br />

<strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong><br />

David Geffen School of Medicine at <strong>UCLA</strong><br />

100 <strong>Stein</strong> Plaza, <strong>UCLA</strong><br />

Box 957000<br />

Los Angeles, CA 90095-7000<br />

U.S.A.<br />

<strong>Jules</strong> <strong>Stein</strong> <strong>Eye</strong> <strong>Institute</strong> <strong>Clinical</strong><br />

<strong>and</strong> <strong>Research</strong> <strong>Seminar</strong><br />

May 18-19, 2007<br />

38th <strong>Jules</strong> <strong>Stein</strong> Lecturer<br />

David L. Guyton, MD<br />

Zanvyl Krieger Professor of Pediatric Ophthalmology<br />

The Johns Hopkins University School of Medicine<br />

5th Bradley Straatsma Lecturer<br />

Robert E. Marc, PhD<br />

Mary H. Boesche Professor of Ophthalmology<br />

University of Utah School of Medicine<br />

5th Thomas Pettit Lecturer<br />

Edward E. Manche, MD<br />

Associate Professor of Ophthalmology<br />

Stanford University School of Medicine

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