Poss CV - Montana-Ecology of Infectious Diseases (M-EID ...

Curriculum Vitae
Mary Poss
405 Skyline Dr
Missoula, MT 59802
EDUCATION
Duke University, Durham NC BS 1975 Zoology
University of New Hampshire, Durham NH MS 1979 Biochemistry
Ohio State University, Columbus, OH DVM 1984 Veterinary Medicine
Colorado State University, Ft. Collins, CO PhD 1990 Exptl Pathology
INTERNSHIPS AND RESIDENCIES
Food Animal Intern 1984 Navajo Nation, Tsaile, AZ
Food Animal Intern 1984 US Sheep Experimental Station Dubois, ID
Pathology Resident 1985-87 Colorado State University, Ft. Collins, CO
PROFESSIONAL EXPERIENCE
Veterinarian 1984 Rushford, NY
Mixed animal practice
Post-doctoral fellow 1990-91. Icos Corp, Bothell, WA.
Characterization of signal transduction by cell adhesion molecules
Senior Staff Scientist 1991-93. Icos Corp, Bothell, WA.
Characterization of signal transduction by cell adhesion molecules
Senior Fellow 1994-98 University of Washington, Seattle, WA.
Functional evolution of HIV-1 gp120 from early seroconvertors
Assistant Professor 1998-02. Division of Biological Sciences & Wildlife
Biology, University of Montana, Missoula, MT.
Clinical Assistant Professor 1999- Tufts University School of Veterinary
Medicine, North Grafton, MA.
Associate Professor 2002- Division of Biological Sciences & Wildlife
Biology, University of Montana, Missoula, MT
HONORS AND AWARDS
National Research Service Award (F32 AI07814) 1988-91 $72,000
Analysis of feline AIDS retrovirus glycoproteins
Clinical Investigator Award (K08 AI012190) 1994-97 $230,000
Functional evolution of HIV variant viruses
CFAR New Investigator Award 1995-96 $77,000
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RESEARCH GRANT SUPPORT, 1998-PRESENT
Selective forces on the evolution and biology of clade A HIV-1
Funding source: NIH-NIAID R01 AI44609 (Poss, PI)
Duration: 12/01/98-12/01/02
Total amount: $841,233
Retroviral evolution and host population dynamics
Funding source: MONTS (Poss, PI)
Duration: 7/1/99-6/30/00
Total amount: $24,990
Inference of spatial population structure and disease incidence in two lynx
populations
Funding source: Wilburforce Foundation (Poss, PI)
Duration: 05/06/00-04/30/01
Total amount: $15,000
Incidence of FIV co-infection and recombination in cougars
Funding source: University Grant Program (Poss, PI)
Duration: 5/1/01-8/30/02
Total amount: $4,000
Inferring connectivity among cougar populations along the Central Rocky
Mountains based on genetic relationships in a common pathogen
Funding source: Wilburforce Foundation (Poss, PI)
Duration: 7/01/01-4/30/02
Total amount: $21,000
Epidemiology of Feline Immunodeficiency Virus (FIV) in a free-ranging cougar
population
Funding source: Morris Animal Foundation (Poss, PI)
Duration: 7/15/01-7/15/04
Total amount: $45,000
Using retroviral evolution to elucidate host population dynamics and
mechanisms of infection persistence and pathogenesis.
Funding source: NSF-EPSCoR state competitive Grants. (Poss, PI)
Duration: 6/1/02-6/30/03
Total amount: $35,000
Inferring connectivity among cougar populations along the Central Rocky
Mountains based on genetic relationships in a common pathogen
Funding source: Wilburforce Foundation (Poss, PI)
Duration: 7/01/02-2/30/03
Total amount: $25,000
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Inferring connectivity among cougar populations along the Central Rocky
Mountains based on genetic relationships in a common pathogen
Funding source: Wilburforce Foundation (Poss, PI)
Duration: 05/06/03-02/30/04
Total amount: $20,000
Dissertation Research: Disease ecology and retrovirus evolution in a wild felid
Funding source: NSF- DDIG (awarded to R. Biek. M Poss is PI as
research advisor.)
Duration: 7/0102-6/30/04
Total amount: $7,790
Mechanisms of feline lentivirus interference
Funding source: NIH-NIAID-RO1 AI52055 (PI S VandeWoude,
Colorado State University, Poss, co-PI)
Duration: 8/11/02-7/31/06
Sub contract to UM - total amount: $400,000
Renewal to be submitted in Sept 2005
Characterization of cougar lentiviruses
Funding source: NIH-NIAID R15 AI054303 (Poss, PI)
Duration: 6/1/03-5/31/06
Total amount: $140,000
Montana Ecology of Infectious Diseases: IGERT
Funding source: NSF (Poss, co-PI)
Duration: pending, 12/01/05-11/30/10
Total amount: $3,260,729
Function and Structure of Feline Lentivirus Reverse Transcriptases
Funding source: NSF-EPSCOR
Duration: 7/1/05-6/30/06
Total amount $25,000
Role of Coinfection and Recombination in the Evolution of Lentivirus Infections
Funding source: NIH R01 AI067933 (Poss, PI)
Duration: not funded, in revision
Total amount: $1,773,358
Comparison of feline lentivirus polymerase properties in vivo and in vitro
Funding source: NIH-NAID R21 AI068573 (Poss, PI)
Duration: not funded, in revision
Total amount: $385,637
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TEACHING
Courses
Elementary Microbiology Laboratory each semester
Virology annual
Seminar in Virus Evolution each semester
Introductory Biology and Laboratory (team) 1999
Virology Research Laboratory 1999-2001
Plague (team) 2002
Advanced Undergraduate Research 1999-2005
Microbes to Megafauna (Graduate) 2001
Introduction to Research (Graduate) 2002-03
Infectious Disease 2003
Virus Evolution and Ecology (Graduate) 2002
Advanced Virology (Graduate) 2004
Undergraduate mentoring
Ingunn Stromnes Indep Res 1999-00
Erin Bentley Indep Res 1999
Rita Luther Indep Res 1999-00
Erich Timko WBIO honors student. 2000-01
Jesse Thompson McNair Scholar 2000-01
Naomi Akamine IBS-CORE Fellow, Indep Res 2000-03
Jocelyn Spoon, EPSCoR Fellow 2001
Jo Nord Indep Res 2001
Emily Villegas IBS-CORE Fellow, Indep Res 2002-03
Virginia Shay BRIN Fellowship 2002-03
Kari Samuel BRIN Fellowship, Indep Res 2002-04
Jenn Archibald Indep Res 2004-05
Graduate Students
Roman Biek Wildlife Biology PhD 2004
David Blake Molecular Biology MS 2005
Jingjing Wang Biochemistry MS Expect 2006
Michael Ceballos Interdisciplinary PhD
ACADEMIC SERVICE
Institutional Animal Care and Use Committee 1999-05
Curriculum Development Committee 1999-02
Pre-medical Advising Committee 1999-04
Pathology Consultant 1999-04
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IGERT Committee Chair 2000-04
Graduate Education Committee, Chair 2001-04
DBS Curriculum Committee, Chair 2001-02
Graduate Admissions Committee 2001-05
Wildlife Disease Search Committee, Chair 2002-03
UM Rhodes Scholar Interview Committee 2003
Faculty advisor UM AISES 2004-05
PROFESSIONAL SERVICE
Grant Reviewer
UM EPSCOR 2001
Montana Academy of Science 2003
National Fish and Wildlife Foundation 2003-04
AAAS-First Award 2004
NIH Special Emphasis panel ZAI1-DP-A 2004
NSF. External Reviewer 2005
Reviewer for:
Animal Conservation
Conservation Biology
Journal of Infectious Diseases
Journal of Virology
Journal of Wildlife Diseases
Science
Virology
Professional Association Memberships
American Association for the Advancement of Science
American Society for Microbiology
American Society of Virology
Wildlife Disease Association
WORKSHOPS, COURSES, AND CONFERENCES
Organizer
Wetland Ecology Training for Elementary School Teachers
Methow Valley, WA July 1995-97
Symposium on Conservation Medicine
Society for Conservation Biology, Missoula, MT June 2000
Ecology and Evolution of Infectious Diseases
Ft. Collins, CO May 2005
Instructor
Conservation Medicine Short Course
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Grafton, MA. April 2001
Conservation Biology and Veterinary Medicine
UC Davis, Davis, CA Feb 2003
Participant
Host Behavior and Disease, NCEAS
Santa Barbara, CA 2001-03
Science-Based Assessment Of Microbe Management In The Context Of The
National Park Service Mission
Ft. Collins, CO Jan 2003
Invited Speaker (selected) 1999-2005
Functional Evolution of clade A HIV-1
Rocky Mountain Labs, Hamilton, MT Jan 1999
Lentiviral Population Biology
Gordon Research Conference, Williams College, MA July 2001
A Pathologist’s Perspective On Retrovirus Ecology And Evolution
Princeton University, Princeton, NJ April 2002
Pathogens And Predators: Using Viruses To Track Wildlife Populations
Symposium Emerging Infectious Diseases, Arcata, CA July 2002
Tracking Predators with Pathogens
Smithsonian, Washington DC April 2003
Comparison Of Endemic And Epidemic Lentivirus Infections In Natural Host
Populations: Lessons For Peaceful Co-Existence
Symposium on Disease Invasions, State College, PA May 2003
Merging Virus And Host Population Dynamics
Disease Ecology and Evolution. Atlanta, GA May 2004
Tracking Predators with Pathogens
University of Auckland, NZ Dec 2004
The Yin and Yang of Immune Responses
Ecology and Evolution of Infectious Diseases, CO May 2005
The Molecular biology, ecology and evolution of lentiviruses Oct 2005
Penn State University, State College PA
BIBLIOGRAPHY
Poss, ML & S Young. 1987. Dysplastic disease of the cerebellum of an adult
horse. Acta Neuropathol. 75:209-211.
Dow, SD, RA LeCouter, RA Henik, and ML Poss. 1988. Central nervous system
infections associated with anaerobic bacteria in 2 dogs and 2 cats. J. Coll. Vet.
Int. Med. 2:171-176.
Mullins, JI, EA Hoover, J Overbaugh, SL Quackenbush, PR Donahue, and ML.
Poss. 1989. FeLV-FAIDS induced immunodeficiency syndrome in cats. Vet.
Immunol and Immunopath. 21:25-37.
Mullins, JI, EA Hoover, M Murphy-Corp, PR Donahue, J Overbaugh, and ML
Poss. 1989. Molecular aspects of the FeLV and SIV AIDS models. In:
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Retroviruses of Human AIDS and Related Animal Diseases. (M. Girard, L.,
Valerre, Eds.; Foundation Marcel Merieux, Lyon, France).
Dow, SD, RA LeCouter, ML Poss and D Beadleston. 1989. Central nervous
system toxicity associated with metronidazole treatment of dogs. J. Am. Vet.
Med. Assoc. 195:365-368.
Poss, ML, JI Mullins and EA Hoover. 1989. Post-translational modifications
distinguish the envelope glycoprotein of the immunodeficiency diseaseinducing
Feline Leukemia Virus retrovirus. J. Virol. 63:189-195.
Pearson, L, ML Poss, and J DeMartini. 1989. Animal lentivirus vaccines:
Problems and prospects. Vet. Immunol. Immunopathol. 20:183-212.
Poss, ML, JI Mullins and EA Hoover. 1990. Characterization and significance of
delayed processing of the FeLV-FAIDS envelope glycoprotein. J. Virol.
64:4338-4345.
Dow, SD, ML Poss and EA Hoover. 1990. Feline Immunodeficiency Virus: A
neurotropic lentivirus. JAIDS. 3:658-668.
Hoover, EA, SL Quackenbush, ML Poss, J Overbaugh, PR Donahue, and JI
Mullins. 1990. Pathogenic mechanism of Feline Leukemia Virus induced
immunodeficiency syndrome. In: Animal Models in AIDS (H. Schellekens and
M. C. Horzinek, Eds.; Elsevier Scince Publishers).
Hoover, EA, SL Quackenbush, ML Poss, RE Dornsife, J Overbaugh et al. 1990.
Pathogenic mechanisms of immunodeficiency syndrome and aplastic anemia
induced by Feline Leukemia Viruses. Dev. Biol. Stand, 72:163-166.
Poss, ML, SD Dow, and EA Hoover. 1992. Cell specific FIV envelope
glycosylation leads to fusion of infected astrocytes. Virology. 188:25-33.
Burns, CB, ML Poss, E Thomas, and J Overbaugh. 1995. Mutations within a
putative cysteine loop of the transmembrane protein of an attenuated
immunodeficiency-inducing feline leukemia virus variant inhibit envelope
protein processing. J Virol. 69:2126-2132.
Poss, ML, HL Martin, JK Kreiss, L Granville, B Chohan, P Nyange, K Mandaliya
and J Overbaugh. 1995. Diversity in virus populations from genital secretions
and peripheral blood in women recently infected with HIV-1. J. Virol. 69:8118-
8122.
Poss, M, J Gosink, E Thomas, JK Kreiss, JO Ndinya-Achola, K Mandaliya, J
Bwayo and J Overbaugh. 1997. Phylogenetic evaluation of Kenyan HIV-1
isolates. AIDS Res and Hum Retroviruses. 13:493-499.
Poss, M, AG Rodrigo, J Gosink, GH Learn, D Panteleef, HL Martin, Jr, J Bwayo,
JK Kreiss, and J Overbaugh. 1998. Evolution of envelope sequences from the
genital tract and peripheral blood of women infected with clade A human
immunodeficiency virus type 1. J. Virol. 72:8240-8251.
Poss, M and J Overbaugh. 1999. Variants from the diverse virus population at
seroconversion of a clade A human immunodeficiency virus type 1 infected
woman have distinct biological properties. J Virol. 72:5255-5264.
Overbaugh, J, J Kreiss, M Poss, P Lewis, S Mostad, G John, R Nduati, D Mbori-
Ngacha, H Martin Jr, B Richardson, S Jackson, J Neilson, EM Long, D
Panteleeff, M Welch, J Rakwar, D Jackson, B Chohan, L Lavreys, K
Mandaliya, J. Ndinya-Achola, and J Bwayo. 1999. Studies of human
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immunodeficiency virus type 1 mucosal viral shedding and transmission in
Kenya. J Infect Dis. 179 Suppl 3:S401-4
Poss, M, R. Biek and A. Rodrigo. 2001. Virus as Evolutionary Tools to Monitor
Population Dynamics. In: Conservation Medicine: Ecological Health in Practice.
(Aguirre, AA, RS Ostfeld, CA House, GM Tabor and MC Pearl, eds.) Oxford
University Press, New York.
Tabor, GM, RS Ostfeld, M Poss, AP Dobson, AA Aguirre, 2001. Conservation
Biology and the Health Sciences: Defining the Research Priorities of
Conservation Medicine. In: Research priorities in Conservation Biology. 2nd
edition. (ME Soulé and GH Orians. eds Island Press; Washington, D.C.
Biek R, RL Zarnke, C Gillin, M Wild, JR Squires, M Poss 2001. Serological
survey for viral and bacterial diseases in western populations of the Canada
lynx (Lynx canadensis). .J Wildlife Dis. 38:840-845.
Biek, R, AG Rodrigo, D Holley, A Drummond, C Anderson, M Poss. 2003.
Epidemiology, genetic diversity, and molecular evolution of endemic FIV in a
wild population of cougars J. Virol. 77:9578
Painter, SL, R Biek, DC Holley, and M Poss. 2003. Envelope variants from
women recently infected with clade a human immunodeficiency virus type 1
confer distinct phenotypes that are discerned by competition and neutralization
experiments. J. Virol. 77:8448.
Altizer, S, C Nunn, P Thrall, JL Gittleman, J Antonovics, A Cunningham, A
Dobson, V Ezenwa, KE Jones, AB Pedersen, M Poss, JRC Pulliam. 2003.
Social organization and parasite risk in mammals: integrating theory and
empirical studies. Ann Rev Ecol Evol Syst. 34: 517-47
Poss, M, DC Holley, R Biek, H Cox, J Gerdes.2004. Development of a homology
model for clade A human immunodeficiency virus type I gp120 to localize
temporal substitutions arising in recently infected women. J Gen Virol 85:1479-
1484.
Pedersen, AB, S Altizer, M Poss, AA Cunningham, CL Nunn. 2005. Patterns of
host specificity and transmission among parasites of wild primates. Intl J
Parisitol. 35: 647-657.
Smirnova, N, JL Troyer, J Schissler, JA Terwee, M Poss, S VandeWoude. 2005.
Feline lentiviruses demonstrate differences in receptor repertoire and envelope
structural elements. Virol. 342:60-76.
Biek, R, N Akamine, M Schwartz, TK Ruth, KM Murphy, M Poss. 2005. Longterm
genetic effects of sex-biased dispersal in a solitary carnivore: Yellowstone
cougars. In revision. Biol Letters.
Biek, R, TK Ruth, KM Murphy, CR Anderson, Jr., M Poss. 2005. Examining
effects of persistent retrovirus infection on fitness and pathogen susceptibility in
a natural feline host. Submitted. Can J Zool.
Biek, R, TK Ruth, KM Murphy, CR Anderson, Jr., M Johnson, R DeSimone, R
Gray, MG Hornocker, CM Gillin, M Poss. 2005. Factors associated with
microparasite seroprevalence and infection risk in Rocky Mountain cougars.
Submitted. J Wildlife Dis.
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Blake, D, J Graham, M Poss. 2005. Quantification of Feline Immunodeficiency
Virus (FIVpco) in peripheral blood mononuclear cells, lymph nodes and plasma
of naturally infected cougars. In press, J Gen Virol
Poss, M, HA Ross, SL Painter, DC Holley, JA Terwee, S VandeWoude, A
Rodrigo. 2005. Feline lentivirus evolution in cross-species infection reveals
high error burdens and selection on key residues in the viral polymerase. In
revision, J Virol
Biek, R, A Drummond, M Poss. 2005. Virus reveals population structure and
recent demographic history of carnivore host. In review, Science
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