Morning Report
Morning Report
Morning Report
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
GVHD - Treatment<br />
• Steroids are used to treat acute clinical GVHD<br />
• T-cell Immunosuppressives<br />
o Cyclosporine - inhibits IL-2, renal toxicity<br />
o Tacrolimus inhibits IL-2, renal toxicity, neurotoxicity, target<br />
trough for GVHD is 10-30<br />
o Sirolimus - inhibits IL-2 transcription, more GI side effects<br />
than tacro<br />
o Mycophenolate - inhibits purine synthesis, key for T-cell<br />
activation, GI toxcity, marrow suppression, black box:<br />
progressive multifocal leukoencephalopathy.<br />
• Anti-thymocyte thyroglobulin<br />
• IVIg<br />
• Hydroxychloroquine - chronic GVHD, eye side effects<br />
• TNF-a inhibitors show 70% reduction of acute GVHD in<br />
animal models
Change language