Implantable infusion pumps for chronic rodent studies

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AngII-salt hypertension in the rat High NaCl diet: 2.0% Normal NaCl diet: 0.4% Low NaCl diet: 0.1% 2ML2 model Most measurements made continuously over entire experimental protocol • Arterial pressure and heart rate (telemetry) • Sympathetic nerve activity (hardwired and telemetry) • Whole body and regional norepinephrine spillover
The “classic” AngII-salt response Osborn and Fink. Exp Physiol. 95(1): 61-68, 2010. Neurogenically Mediated
Page 1 and 2: Implantable infusion pumps for chro
Page 3 and 4: Current available options • Alzet
Page 5 and 6: Alzet :Design and models Design Con
Page 7 and 8: Alzet: Filling the pump ALWAYS USE
Page 9 and 10: Alzet: Implanting the pump Use ster
Page 11 and 12: iPRECIO is programmable Infusion mo
Page 13 and 14: Alzet Model 1002: $28/pump Model 20
Page 15: Sympathetic signature of AngII-salt
Page 19 and 20: Variable infusion rates do not expl
Page 21 and 22: Addition of BSA to infusate improve
Page 23 and 24: Big pumps and small pumps are not t
Page 25: Alzet iPRECIO Summary Pros Cons Mic

Implantable infusion pumps for chronic rodent studies

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